Compare Supplements

Side-by-side comparison of 2 supplements

Rsh5.0

Rosehip

High safety

Tir7.8

Tirzepatide

Limited safety

Evidence

Evidence Score5/10

Studies: 5

Meta-analyses: 1

Evidence Score7.8/10

Studies: 13

Meta-analyses: 2

Dosage & timing

Dosage:

5g daily of standardized rosehip powder (the dose used in the OA trials)

Best Time:

With meals · with food

Take with food

Form:

Standardized rosehip powder (GOPO-standardized)

Dosage:

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

What you'll notice

🦵 Reduced osteoarthritis painpositive

3 weeks to 3 months

💊 Lower rescue-medication usepositive

3-12 weeks

ℹ️ Effect is modestneutral

Throughout use

🩸 Strong glycemic controlpositive

Weeks to months

⚖️ Large weight losspositive

Months (dose-escalated over ~20 weeks)

😴 Reduced sleep-apnea severitypositive

Weeks to months

Safety

High safety

Contraindications:

Known allergy to Rosa species
Caution with high doses of vitamin C in those prone to oxalate kidney stones

Drug Interactions:

Warfarin / anticoagulants

Side Effects:

Mild GI upset / loose stools

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN2)
History of pancreatitis (use with caution / avoid)

Drug Interactions:

Oral contraceptives
Insulin and sulfonylureas
Oral medications generally

Side Effects:

NauseaDiarrheaVomiting

Works well with

Glucosamine

complementary

Boswellia

complementary

Curcumin

complementary

No synergies listed

How they work together

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