Compare Supplements

Side-by-side comparison of 2 supplements

Sam9.0

SAMe

Moderate safety

Zn9.0

Zinc

High safety

Evidence

Evidence Score9/10

Studies: 14

Meta-analyses: 32

Evidence Score9/10

Studies: 43

Meta-analyses: 36

Outcome Grades

Support moodA

Support moodC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

1000mg

Best Time:

Morning

Can take on empty stomach

Form:

Enteric-coated tablets (SAMe tosylate or butanedisulfonate)

Dosage:

20mg

Best Time:

Evening · with food (preferred)

Take with food

Form:

Zinc picolinate or zinc citrate

What you'll notice

😊 Mood Improvement65%

2-6 weeks

🦵 Joint Pain Relief60%

4-8 weeks

🫀 Liver Support55%

4-8 weeks

🛡️ Stronger Immunity75%

2-4 weeks

😴 Improved Sleep60%

2-4 weeks

💪 Testosterone Support55%

4-8 weeks

Safety

Moderate safety

Contraindications:

Bipolar disorder (may trigger mania)
Parkinson's disease on levodopa

Drug Interactions:

Antidepressants (SSRIs, MAOIs, tricyclics)
Levodopa
Tramadol and other serotonergic drugs

Side Effects:

GI upset/nauseaAnxiety/restlessnessInsomnia

High safety

Contraindications:

Copper deficiency (zinc depletes copper)

Drug Interactions:

Antibiotics (fluoroquinolones, tetracyclines)
Penicillamine
Diuretics

Side Effects:

NauseaMetallic tasteCopper deficiency (long-term high dose)

Works well with

B-Complex (B12/Folate)

enhances

complementary

complementary

stacks-well

complementary

How they work together

Like what you see? Add these to your stack.

See how they work together through biological pathways.

Build Your Stack

Want to compare more supplements?

Loading comparison...