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Sarcosine

Evidence Score3.8/10

Studies: 5

Meta-analyses: 1

Dosage:

500-2000 mg/day in trials (schizophrenia commonly 2 g/day add-on; OCD trials 500-2000 mg/day)

Best Time:

Morning · with food

Take with food

Form:

Sarcosine (N-methylglycine)

🧩 Adjunctive symptom improvement (schizophrenia)40%

2-6 weeks

🤔 Cognitive effect (weak / unproven)25%

6-12 weeks

🙂 Mood / OCD signal (preliminary)25%

2-10 weeks

Moderate safety

Contraindications:

Patients on clozapine (meta-analysis found no benefit when added to clozapine; some signal of worsening reported elsewhere)
Pregnancy/breastfeeding (not studied)
Self-treatment of serious psychiatric illness without clinical supervision

Drug Interactions:

Side Effects:

HeadacheMild GI upset

complementary

complementary

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