Compare Supplements

Side-by-side comparison of 2 supplements

Sil3.8

Sildenafil (Viagra)

Moderate safety

Tdl3.0

Tadalafil

Limited safety

Evidence

Evidence Score3.8/10

Studies: 6

Meta-analyses: 1

Evidence Score3/10

Studies: 5

Meta-analyses: 0

Dosage & timing

Dosage:

Approved on-demand ED dosing is 25-100 mg taken ~30-60 minutes before activity (50 mg typical start). PAH dosing (Revatio) is 20 mg three times daily. Any off-label use is clinician-directed; this is not an approved longevity regimen.

Best Time:

Any time

Can take on empty stomach

Form:

Oral tablet (sildenafil citrate)

Dosage:

Off-label longevity/vascular use mirrors low approved dosing (e.g. tadalafil 2.5–5 mg once daily, the dose used for BPH/daily ED) under a clinician. Not an approved longevity regimen.

Best Time:

Any time

Can take on empty stomach

Form:

Low daily-dose oral tablet

What you'll notice

💪 Erectile dysfunction (proven)positive

Acute (~30-60 min onset)

🫁 Pulmonary arterial hypertension (proven)positive

Weeks

🧠 Possible lower dementia risk (associational)trade-off

Years

📊 Lower mortality (associational)positive

Years

🧠 Possible lower dementia riskpositive

Years

🩸 Endothelial / vascular benefitpositive

Acute to weeks

Safety

Moderate safety

Contraindications:

Concurrent nitrates (any form)
Recent cardiovascular event / unstable angina
Severe hypotension

Drug Interactions:

Nitrates
Alpha-blockers / antihypertensives
Strong CYP3A4 inhibitors

Side Effects:

Headache / flushingDyspepsia / nasal congestion / blue-tinged or blurred visionPriapism / NAION (sudden vision loss) / sudden hearing loss / symptomatic hypotension

Limited safety

Contraindications:

Concurrent nitrates (any form)
Recent cardiovascular event / unstable angina
Severe hypotension

Drug Interactions:

Nitrates
Alpha-blockers / antihypertensives
Strong CYP3A4 inhibitors

Side Effects:

Headache / flushingNasal congestion / indigestion / back painHypotension / priapism / sudden vision or hearing changes

How they work together

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