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Prescription-only and clinician-directed — this is a controlled substance, NOT a self-administered supplement, and we do not provide a non-medical dosing protocol. For context only: TRT for diagnosed hypogonadism is titrated to a mid-normal testosterone level. Intramuscular testosterone esters (cypionate/enanthate) are commonly dosed around 50–100 mg weekly (or ~100–200 mg every 2 weeks); long-acting testosterone undecanoate is dosed less frequently. Transdermal gels (~50–100 mg/day applied) and subcutaneous injection are alternative routes. Supraphysiologic anabolic-steroid doses are far higher, illegal, and dangerous — not a regimen this library endorses.

Any time

Clinician-prescribed testosterone (intramuscular ester or transdermal gel) for diagnosed hypogonadism — controlled substance, prescription-only

Standardized yohimbine ~5-10mg (or ~0.2mg/kg) up to 1-2x daily; start at the lowest dose. Raw yohimbe bark is discouraged due to unpredictable content.

Morning

Standardized yohimbine HCl (known dose)

• Use without a prescription / without medical supervision — testosterone is a Schedule III controlled substance and prescription-only
• Active prostate cancer or active breast cancer in men
• Untreated severe erythrocytosis / hematocrit above the safe threshold

• Anticoagulants / warfarin
• Other anabolic steroids / SARMs / hCG / aromatase inhibitors
• Insulin / glucose-lowering drugs

• Hypertension or cardiovascular disease
• Anxiety, panic, or other psychiatric disorders
• Kidney or liver disease

• MAO inhibitors
• SSRIs/SNRIs and other serotonergic/noradrenergic drugs
• Stimulants (caffeine, other sympathomimetics)