Compare Supplements

The only legitimate dose is a clinician-supervised prescription, where tianeptine is approved: 12.5 mg three times daily (37.5 mg/day) for major depression, sometimes adjusted in elderly or renally-impaired patients. This library does NOT provide a self-dosing protocol. It is NOT FDA-approved in the US, where it is sold illicitly and unregulated, and it is a mu-opioid agonist with abuse, dependence and overdose liability. The supratherapeutic 'gas station heroin' doses people misuse (hundreds of mg to grams per day) are dangerous, unstudied at those levels, and have caused overdose with respiratory depression. Therapeutic-dose figures are listed for context only, not as a recommendation to self-administer.

Split through the day

Oral tianeptine sodium 12.5 mg tablet (prescription — Stablon/Coaxil), three times daily under medical supervision where approved; no over-the-counter or US 'supplement' form is endorsed

• Any non-prescription / US use — tianeptine is NOT FDA-approved in the US; products sold there are unapproved and unregulated, and it is a mu-opioid agonist with abuse, dependence and overdose liability
• Personal or family history of substance-use disorder, especially opioid use — high risk of misuse, dependence and escalation
• Concurrent use of opioids, benzodiazepines, alcohol or other CNS depressants — additive respiratory-depression and overdose risk

• Opioids / other mu-opioid agonists
• Benzodiazepines / alcohol / other CNS depressants
• MAO inhibitors