Supplements vergleichen

Off-label longevity use mirrors diabetes dosing (commonly 500–1500 mg/day of extended-release with meals) under a clinician. Not an approved longevity regimen, and unnecessary in well-controlled non-diabetics without a clear rationale.

With meals · with food

Extended-release tablet

Off-label metabolic use mirrors diabetes dosing (e.g. 15–45 mg once daily) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Orale Tablette (Pioglitazon)

• Severe renal impairment (eGFR < 30)
• Acute metabolic acidosis
• Conditions predisposing to lactic acidosis (severe hypoxia, decompensated heart failure)

• Iodinated contrast
• Alcohol (excessive)

• Symptomatic heart failure (NYHA III–IV)
• Active or history of bladder cancer
• Active liver disease / significant hepatic impairment

• Insulin
• Gemfibrozil (CYP2C8 inhibitor)
• Insulin secretagogues (sulfonylureas)