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Alc7.0
Acetyl-L-Carnitine – Forschung
Hilft wahrscheinlich
111 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Acetyl-L-Carnitine half in etwa der Hälfte (6/9) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1988–2026 mit einer typischen Studiengröße von 68 Teilnehmenden.
Basierend auf 111 Studien · 17 Meta-Analysen · 71 RCTs · 8,954 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
6geholfen3unklar· 102 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung33 Studien
Neuroprotection & brain agingBesseres Gedächtnis, insbesondere bei älteren Erwachsenen · 4-12 weeks
Überwiegend Mechanismus / Beobachtung24 Studien
Cognitive functionAntidepressive Wirkung, in Metaanalysen mit einigen Medikamenten vergleichbar · 4-8 weeks
Hilft wahrscheinlich17 Studien
Depression & moodKann die reproduktive Gesundheit und Fertilitätsmarker unterstützen · 4-12 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Energy & fatigueModerate entzündungshemmende Wirkung über mitochondriale Unterstützung · 4-8 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung7 Studien
Fertility & reproductive
Überwiegend Mechanismus / Beobachtung5 Studien
Glucose & metabolicUnterstützt die mitochondriale Funktion und den zellulären Energiestoffwechsel · 8-12 weeks
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 32 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
8,954
typische Studie: 68 Personen
Stärkste Designs
88
17 gepoolt, 71 randomisiert
Zeigte Nutzen
67%
6/9 Studien
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
2
3+ Monate
1
Untersuchte Populationen
Hepatic encephalopathy patients2
Multiple sclerosis patients2
Major depressive disorder patients2
Fibromyalgia patients2
Stetige Forschung
28 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
198820072026
1Erectile function improvementMeta-Analysen=1,000 · large study2024
Einfach gesagt: Against a background of general ineffectiveness of most nutraceutical interventions, L-Arginine and the mix PLC + ALC appeared to be of some usefulness in improving erectile function, especially in combination with PDE5i in organic ED.
Barbonetti A et al. · The journal of sexual medicine (2024)
In patients with organic ED, the efficacy of Sildenafil and Tadalafil was significantly improved by PLC + ALC and L-Arginine, respectively.
Against a background of general ineffectiveness of most nutraceutical interventions, L-Arginine and the mix PLC + ALC appeared to be of some usefulness in improving erectile function, especially in combination with PDE5i in organic ED.
3Differential metabolites identificationMeta-Analysen=495 · medium study2023
Einfach gesagt: The main differential metabolites between OA and healthy subjects were amino acids and their derivatives, including tryptophan, lysine, leucine, proline, phenylalanine, glutamine, dimethylglycine, citrulline, asparagine, acetylcarnitine and creatinine, which could be potential biomarkers for predicting OA.
Liao Z et al. · Nutrients (2023)
In the 13 studies, 132 kinds of small molecule differential metabolites were extracted, 58 increased, 57 decreased and 17 had direction conflicts.
Among them, 37 metabolites appeared more than twice.
4Serum ammonia levelMeta-Analysen=660 · large study2013
Einfach gesagt: Acetyl-L-carnitine is promising as an effective and tolerable treatment for hepatic encephalopathy that associated with improved serum ammonia levels and the number connection test.
Jiang Q et al. · Annals of hepatology (2013)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Acetyl-L-carnitine was effective to improve serum ammonia level (weighted mean difference 25.90, 95% confidence intervals 20.89 to 30.91, P < 0.05) and the number connection test completion time (weighted mean difference 16.62, 95% confidence intervals 9.88 to 23.36, P < 0.05).
Acetyl-L-carnitine is promising as an effective and tolerable treatment for hepatic encephalopathy that associated with improved serum ammonia levels and the number connection test.
Jiang Q, Jiang G, Shi KQ, Cai H, Wang YX, Zheng MH · Ann Hepatol (2013)
7Sperm quality and pregnancy ratesMeta-Analyse2025
Einfach gesagt: CoQ10 was the most effective intervention measure for improving sperm concentration, and L-carnitine was regarded as the best treatment method for enhancing sperm motility.
Niu C et al. · Reproductive sciences (Thousand Oaks, Calif.) (2025)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
L-carnitine, coenzyme Q10 and L-carnitine + acetyl-L-carnitine significantly improved sperm quality parameters compared with placebo.
CoQ10 induced the highest increase in sperm concentration (SMD 2.98 [95% CI: 1.13 to 7.87]).
Furthermore, L-Carnitine has the greatest improvement effect on progressive sperm motility (SMD 4.19 [95% CI: 1.60 to 10.95]).
Einfach gesagt: Duloxetine is an effective and well-tolerated option, while pregabalin shows promising results but requires further investigation.
Jesus Palma AC et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses (2025)
Investigated medications exhibited varied outcomes, with some showing significant benefits in reducing neuropathic pain while others did not demonstrate statistically significant efficacy.
Duloxetine is an effective and well-tolerated option, while pregabalin shows promising results but requires further investigation.
Other agents, such as venlafaxine and tapentadol, lack strong supporting evidence.
9Clinical outcomes and quality of life in breast cancer patientsSystematische Übersichtn=45 · small study2025
Einfach gesagt: However, the evidence is mixed across supplement types, and further research is needed to determine the most effective and safe approaches.
Scafuri L et al. · Nutrients (2025)
Curcumin studies presented mixed results.
Silymarin showed potential for hepatoprotective effects.
Conclusions: These findings highlight the potential of specific dietary supplements to improve various aspects of breast cancer care.
14Global impression of deteriorationMeta-Analysen=217 · medium study2020
Einfach gesagt: There are a variety of controlled trials addressing the effects of dietary interventions for MS with substantial variation in active treatment, comparator, and outcomes of interest.
Parks NE et al. · The Cochrane database of systematic reviews (2020)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Among four trials comparing PUFAs with MUFAs, there may be little to no difference in global impression of deterioration (RR 0.85, 95% CI 0.71 to 1.03; 4 studies, 542 participants; 40% in the PUFA group versus 47% in the MUFA group; low-certainty evidence).
In two trials comparing different PUFAs (omega-3 versus omega-6), there may be little to no difference in relapses (RR 1.02, 95% CI 0.62 to 1.66; 2 studies, 129 participants; 30% in the omega-3 versus 29% in the omega-6 group; low-certainty evidence).
Among three trials comparing omega-3 with omega-6, there may be little to no difference in change in disability progression, measured as mean change in Expanded Disability Status Scale (EDSS) (mean difference (MD) 0.00, 95% CI -0.30 to 0.30; 3 studies, 166 participants; low-certainty evidence).
15Systematische Übersichtn=22 · very small study2024
Einfach gesagt: Based on the review, we cannot recommend any supplement use for the management of CIPN, although further research into N-acetyl-cysteine, l-carnosine, crocin, and magnesium is warranted.
Frediani JK et al. · Pain practice : the official journal of World Institute of Pain (2024)
Based on the review, we cannot recommend any supplement use for the management of CIPN, although further research into N-acetyl-cysteine, l-carnosine, crocin, and magnesium is warranted.
Acetyl-l-carnitine was found to be likely ineffective or harmful.
16Peripheral blood metabolites in major depressive disorderMeta-Analysen=46 · small study2021
Einfach gesagt: MDD patients were characterized by higher levels of asymmetric dimethylarginine, tyramine, 2-hydroxybutyric acid, phosphatidylcholine (32:1), and taurochenodesoxycholic acid and lower levels of L-acetylcarnitine, creatinine, L-asparagine, L-glutamine, linoleic acid... compared with controls.
Pu J et al. · Molecular psychiatry (2021)
Pathway and network analyses revealed altered amino acid metabolism and lipid metabolism, especially for the tryptophan-kynurenine pathway and fatty acid metabolism, in the peripheral system of MDD patients.
Our findings may facilitate biomarker development and the elucidation of the molecular mechanisms that underly MDD.
17Blood ammonium levelsMeta-Analysen=398 · medium study2019
Einfach gesagt: This Cochrane systematic review analysed a heterogeneous group of five trials at high risk of bias and with high risk of random errors conducted by only one research team.
Martí-Carvajal AJ et al. · The Cochrane database of systematic reviews (2019)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The effects of acetyl-L-carnitine compared with placebo on general health at 90 days are uncertain (MD -6.20 points, 95% confidence interval (CI) -9.51 to -2.89).
Meta-analysis showed a reduction in blood ammonium levels favouring acetyl-L-carnitine versus placebo (MD -13.06 mg/dL, 95% CI -17.24 to -8.99; 387 participants; 5 trials; very low-quality evidence).
It is unclear whether acetyl-L-carnitine versus placebo increases the risk of non-serious adverse events (8/126 (6.34%) vs 3/120 (2.50%); RR 2.51, 95% CI 0.68 to 9.22; 2 trials; very low-quality evidence).
18Treatment recommendations for nutraceuticals and phytoceuticals in psychiatric disordersSystematische Übersicht2022
Einfach gesagt: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders.
Sarris J et al. · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2022)
Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders.
However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use.
It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.
Einfach gesagt: There is insufficient evidence that carnitine for the treatment of MS-related fatigue offers a therapeutic advantage over placebo or active comparators.
Tejani AM et al. · The Cochrane database of systematic reviews (2012)
Kein klarer Effekt
← SchlechterKein EffektBesser →
There was no difference between carnitine and amantadine for the number of patients withdrawing from the study due to an adverse event (relative risk ratio 0.20; 95% confidence interval 0.03 to 1.55) and no patients experienced a serious adverse event in either treatment group.
There is insufficient evidence that carnitine for the treatment of MS-related fatigue offers a therapeutic advantage over placebo or active comparators.
Results of the ongoing trial are eagerly anticipated in order to provide clarity.