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Aln4.0

Allantoin (topisch) – Forschung

Überwiegend Mechanismus / Beobachtung

7 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Allantoin (topisch) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus mittelwertigen randomisierten Studien, veröffentlicht 2012–2020 mit einer typischen Studiengröße von 50 Teilnehmenden.

Basierend auf 7 Studien · 5 RCTs · 206 Teilnehmende insgesamt

Konfidenz

Mittlere Konfidenz

Nach Outcome

Wound & ulcer healing
Überwiegend Mechanismus / Beobachtung3 Studien

Ältere Forschungsbasis

Neueste Studie von 2020

20122020

1RCT2014

Chan RJ, Mann J, Tripcony L, Keller J, Cheuk R, Blades R · Int J Radiat Oncol Biol Phys (2014)

Quelle ansehen

2RCT2012

Chan RJ, Keller J, Cheuk R, Blades R, Tripcony L, Keogh S · Radiat Oncol (2012)

Quelle ansehen

3Systematische Übersicht2017

Einfach gesagt: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.

Ferreira EB, Vasques CI, Gadia R, Chan RJ, Guerra EN, Mezzomo LA, De Luca Canto G, Dos Reis PE. · Support Care Cancer (2017)

Systematic review of 13 RCTs of topical agents (including allantoin, trolamine, dexpanthenol, aloe vera) for preventing radiation dermatitis
Found no strong evidence that any topical pharmacological intervention, allantoin included, outperformed controls or placebo
Tempers claims of a robust soothing/protective benefit for topical allantoin in inflamed skin — the key counter-evidence

Quelle ansehen

4RCTn=50 · small study2016

Einfach gesagt: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients' postoperative comfort; however, improved wound healing was observed.

Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, Garrido-Serrano R, Gutiérrez-Corrales A, Gutiérrez-Pérez JL, Torres-Lagares D. · Med Oral Patol Oral Cir Bucal (2016)

Split-mouth randomized trial (n=50 extractions): allantoin-containing gel applied 3x/day for 10 days vs no gel
Wound aesthetic appearance was significantly better in the gel group at day 7 (p=0.001) and day 14 (p=0.01)
No significant difference in swelling or pain; allantoin's individual contribution can't be separated from the other actives

Quelle ansehen

5RCTn=36 · small study2020

Einfach gesagt: The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation.

Sáez-Alcaide LM, Molinero-Mourelle P, González-Serrano J, Rubio-Alonso L, Bornstein MM, López-Quiles J. · Med Oral Patol Oral Cir Bucal (2020)

Split-mouth, double-blind, placebo-controlled RCT (n=36, 72 teeth); gel contained 0.15% allantoin with chlorhexidine, chitosan, and dexpanthenol
Trismus and swelling were significantly less with the gel; wound healing was 'good' in 97.2% vs 22.2% for placebo (p<0.001)
Soothing/anti-inflammatory benefit attaches to the multi-ingredient formulation, not isolated allantoin

Quelle ansehen

6RCTn=120 · medium study2020

Einfach gesagt: Significant reductions were observed in the vascularity, pigmentation and height subgroups of the VSS for those in the group who continued the treatment to 24 weeks.

Güngör ES, Güzel D, Zebitay AG, İlhan G, Verit FF. · J Wound Care (2020)

Randomized study (n=120) of an onion-extract + allantoin + heparin gel for 6 months vs no treatment on hypertrophic C-section scars
Treatment significantly reduced Vancouver Scar Scale vascularity, pigmentation, and height at 24 weeks
A fixed combination product — allantoin is not tested alone; benefit is modest and formulation-level

Quelle ansehen

7In vitro2018

Einfach gesagt: An in vitro scratch assay confirmed the healing activity of tracheloside (more than 2-fold increased healing activity after 24 hours of treatment compared with the control) and revealed that this activity is better than that of allantoin (1.2-fold increased after 24 hours of treatment compared with the control), a positive control.

Kim J, Shin YK, Kim KY. · Evid Based Complement Alternat Med (2018)

In-vitro HaCaT keratinocyte scratch-wound assay using allantoin as the established positive control for wound-healing activity
Allantoin produced a measurable but modest 1.2-fold increase in healing activity vs control at 24 hours
Supports a plausible cell-proliferation mechanism, but the small effect underscores allantoin's modest intrinsic potency

Quelle ansehen

In der Forschungsbibliothek ansehen

Allantoin (topisch) – Forschung

Überwiegend Mechanismus / Beobachtung

Natural oil-based emulsion containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer: a phase 3, double-blind, randomized, controlled trial.

A double-blind randomised controlled trial of a natural oil-based emulsion (Moogoo Udder Cream®) containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer.

Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction.

Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial.

The efficacy of onion extract in the management of subsequent abdominal hypertrophic scar formation.

Promotion of Keratinocyte Proliferation by Tracheloside through ERK1/2 Stimulation.