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Aln4.0
Allantoin (topisch) – Forschung
Überwiegend Mechanismus / Beobachtung
5 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Allantoin (topisch) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 2016–2020 mit einer typischen Studiengröße von 50 Teilnehmenden.
Basierend auf 5 Studien · 3 RCTs · 206 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Wound & ulcer healing
Überwiegend Mechanismus / Beobachtung3 Studien
Ältere Forschungsbasis
Neueste Studie von 2020
20162020
1Systematische Übersicht2017
There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.
Ferreira EB, Vasques CI, Gadia R, Chan RJ, Guerra EN, Mezzomo LA, De Luca Canto G, Dos Reis PE. · Support Care Cancer (2017)
Systematic review of 13 RCTs of topical agents (including allantoin, trolamine, dexpanthenol, aloe vera) for preventing radiation dermatitis
Found no strong evidence that any topical pharmacological intervention, allantoin included, outperformed controls or placebo
Tempers claims of a robust soothing/protective benefit for topical allantoin in inflamed skin — the key counter-evidence
The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation.
Sáez-Alcaide LM, Molinero-Mourelle P, González-Serrano J, Rubio-Alonso L, Bornstein MM, López-Quiles J. · Med Oral Patol Oral Cir Bucal (2020)
Split-mouth, double-blind, placebo-controlled RCT (n=36, 72 teeth); gel contained 0.15% allantoin with chlorhexidine, chitosan, and dexpanthenol
Trismus and swelling were significantly less with the gel; wound healing was 'good' in 97.2% vs 22.2% for placebo (p<0.001)
Soothing/anti-inflammatory benefit attaches to the multi-ingredient formulation, not isolated allantoin
The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients' postoperative comfort; however, improved wound healing was observed.
Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, Garrido-Serrano R, Gutiérrez-Corrales A, Gutiérrez-Pérez JL, Torres-Lagares D. · Med Oral Patol Oral Cir Bucal (2016)
Split-mouth randomized trial (n=50 extractions): allantoin-containing gel applied 3x/day for 10 days vs no gel
Wound aesthetic appearance was significantly better in the gel group at day 7 (p=0.001) and day 14 (p=0.01)
No significant difference in swelling or pain; allantoin's individual contribution can't be separated from the other actives
Significant reductions were observed in the vascularity, pigmentation and height subgroups of the VSS for those in the group who continued the treatment to 24 weeks.
Güngör ES, Güzel D, Zebitay AG, İlhan G, Verit FF. · J Wound Care (2020)
Randomized study (n=120) of an onion-extract + allantoin + heparin gel for 6 months vs no treatment on hypertrophic C-section scars
Treatment significantly reduced Vancouver Scar Scale vascularity, pigmentation, and height at 24 weeks
A fixed combination product — allantoin is not tested alone; benefit is modest and formulation-level
An in vitro scratch assay confirmed the healing activity of tracheloside (more than 2-fold increased healing activity after 24 hours of treatment compared with the control) and revealed that this activity is better than that of allantoin (1.2-fold increased after 24 hours of treatment compared with the control), a positive control.
Kim J, Shin YK, Kim KY. · Evid Based Complement Alternat Med (2018)
In-vitro HaCaT keratinocyte scratch-wound assay using allantoin as the established positive control for wound-healing activity
Allantoin produced a measurable but modest 1.2-fold increase in healing activity vs control at 24 hours
Supports a plausible cell-proliferation mechanism, but the small effect underscores allantoin's modest intrinsic potency