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Arl3.0

Argireline – Forschung

Überwiegend Mechanismus / Beobachtung

6 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Argireline sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 2002–2017.

Basierend auf 6 Studien · 3 RCTs

Konfidenz

Mittlere Konfidenz

Nach Outcome

Skin healthGeringfügige Reduktion des Erscheinungsbilds von Mimikfalten (kosmetisch, kein gesundheitlicher Effekt) · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien

Ältere Forschungsbasis

Neueste Studie von 2017

200220092017

1RCT2013

Lungu C, Considine E, Zahir S, Ponsati B, Arrastia S, Hallett M · Eur J Neurol (2013)

Quelle ansehen

2RCT2013

Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J · Am J Clin Dermatol (2013)

Quelle ansehen

3RCT2017

Einfach gesagt: Our results confirm the antiwrinkle activity of acetyl hexapeptide-3. A significant decrease in TEWL with acetyl hexapeptide-3 treatment is observed.

Raikou V, Varvaresou A, Panderi I, Papageorgiou E. · J Cosmet Dermatol (2017)

Prospective, randomized controlled cosmetic-science study in 24 volunteers comparing acetyl hexapeptide-3, tripeptide-10-citrulline, their combination, and neither, over 60 days
Instrumental skin-microtopography measures (cR2, cR3) confirmed anti-wrinkle activity of acetyl hexapeptide-3
Acetyl hexapeptide-3 also significantly decreased transepidermal water loss (TEWL)

Quelle ansehen

4In vitro2014

Einfach gesagt: the significant cytotoxicity of argireline solution was observed under 18 to 10 000 fold higher concentrations (depending on cells that were examined) in comparison to doxorubicin.

Grosicki M, Latacz G, Szopa A, Cukier A, Kieć-Kononowicz K. · Acta Biochim Pol (2014)

Independent in-vitro cytotoxicity study across HEK-293, IMR-32 neuroblastoma, and human primary skin fibroblasts
Anti-proliferative effects were dose-dependent but appeared only at 18- to 10,000-fold higher concentrations than the reference cytotoxin doxorubicin
Supports a wide topical safety margin for cosmetic-use concentrations

5In vitro2002

Einfach gesagt: skin topography analysis of an oil/water (O/W) emulsion containing 10% of the hexapeptide on healthy women volunteers reduced wrinkle depth up to 30% upon 30 days treatment.

Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. · Int J Cosmet Sci (2002)

Foundational design paper: the hexapeptide Ac-EEMQRR-NH2 ('Argireline') was rationally designed to mimic the cosmetic action of botulinum toxin non-toxically
A 10% O/W emulsion reduced wrinkle depth up to ~30% over 30 days in a small, uncontrolled cohort of healthy women — an appearance measure, not a controlled trial
Mechanistically, the peptide inhibited neurotransmitter release with potency similar to BoNT-A but much lower efficacy, by interfering with SNARE-complex formation/stability

Quelle ansehen

6Übersicht2007

Einfach gesagt: This article reviews the physiological basis and mechanism of action of the active cosmetic ingredient acetyl hexapeptide-8 (Argireline).

Ruiz MA, Clares B, Morales ME, Cazalla S, Gallardo V. · J Cosmet Sci (2007)

Review and formulation paper covering the physiological basis and mechanism of action of acetyl hexapeptide-8 as a cosmetic active
Frames Argireline explicitly as an anti-aging cosmetic ingredient incorporated into emulsions and gels for facial skincare
Emphasizes that delivery and stability in the cosmetic formulation are central to performance

In der Forschungsbibliothek ansehen

Argireline – Forschung

Überwiegend Mechanismus / Beobachtung

Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.

The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study.

The study of cellular cytotoxicity of argireline - an anti-aging peptide.

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Preparation and stability of cosmetic formulations with an anti-aging peptide.