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Arm5.0

Armodafinil (Nuvigil) – Forschung

Überwiegend Mechanismus / Beobachtung

77 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Armodafinil (Nuvigil) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2024.

Basierend auf 77 Studien · 20 Meta-Analysen · 44 RCTs

Konfidenz

Hohe Konfidenz

Nach Outcome

Wakefulness & sleep/wake disorders
Überwiegend Mechanismus / Beobachtung27 Studien
Cognition & off-label use
Überwiegend Mechanismus / Beobachtung23 Studien
Safety profile
Zu wenige bewertete Studien2 Studien

Stetige Forschung

12 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024

200620152024

1Meta-Analyse2015

Andrade C, Kisely S, Monteiro I, Rao S · J Psychiatr Res (2015)

Armodafinil (Nuvigil) – Forschung

Überwiegend Mechanismus / Beobachtung

Antipsychotic augmentation with modafinil or armodafinil for negative symptoms of schizophrenia: systematic review and meta-analysis of randomized controlled trials.

Effect of Wakefulness-Promoting Agents on Sleepiness in Patients with Sleep Apnea Treated with CPAP: A Meta-Analysis.

Effects of Modafinil and Armodafinil in Patients With Obstructive Sleep Apnea: A Meta-analysis of Randomized Controlled Trials.

Pharmacologic interventions for fatigue in cancer and transplantation: a meta-analysis.

Comparative Efficacy and Safety of Wakefulness-Promoting Agents for Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea : A Systematic Review and Network Meta-analysis.

Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.

Excessive daytime sleepiness in obstructive sleep apnea: Indirect treatment comparison of wake-promoting agents in patients adherent/nonadherent to primary OSA therapy.

Prodopaminergic Drugs for Treating the Negative Symptoms of Schizophrenia: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Pharmacotherapy for residual excessive sleepiness and cognition in CPAP-treated patients with obstructive sleep apnea syndrome: A systematic review and meta-analysis.

Modafinil/armodafinil in obstructive sleep apnoea: a systematic review and meta-analysis.

Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta-analysis of randomized controlled trials.

Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.

Dopamine partial agonists and prodopaminergic drugs for schizophrenia: Systematic review and meta-analysis of randomized controlled trials.

The Efficacy of Psychostimulants in Major Depressive Episodes: A Systematic Review and Meta-Analysis.

Therapies for narcolepsy with or without cataplexy: evidence-based review.

Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials.

Indirect treatment comparison of solriamfetol, modafinil, and armodafinil for excessive daytime sleepiness in obstructive sleep apnea.

Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta-analysis.

Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review.

Pharmacological treatments for fatigue associated with palliative care.