Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Ae7.0
Artischockenextrakt – Forschung
Hilft wahrscheinlich
47 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Artischockenextrakt scheint in 6 von 7 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2003–2026 mit einer typischen Studiengröße von 100 Teilnehmenden.
Basierend auf 46 Studien · 9 Meta-Analysen · 18 RCTs · 1,696 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
6geholfen1unklar· 39 weitere ohne bewertete Effektdaten
Nach Outcome
Cholesterol & lipidsSenkt das LDL-Cholesterin und unterstützt den Fettstoffwechsel · 8-12 weeks
Hilft wahrscheinlich41 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung9 Studien
Liver health
Überwiegend Mechanismus / Beobachtung8 Studien
Heart & blood pressureSenkt das LDL-Cholesterin und unterstützt den Fettstoffwechsel · 8-12 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Digestive healthWeniger Blähungen und verbesserter Gallenfluss innerhalb von 2-4 Wochen · 2-4 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
InflammationBessere Verdauung und weniger Blähungen · 2-4 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Weight management
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
In Zahlen
Aus 25 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
1,696
typische Studie: 100 Personen
Stärkste Designs
27
9 gepoolt, 18 randomisiert
Zeigte Nutzen
86%
6/7 Studien
Wie lange Studien liefen
1–3 Monate
5
3+ Monate
1
Untersuchte Populationen
General population6
Patients with functional dyspepsia2
Neurodegenerative disease patients1
Patients with cardiometabolic risk factors1
Aktives Forschungsgebiet
18 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200320142026
1Meta-Analyse2021
Moradi S, Shokri-Mashhadi N, Saraf-Bank S, Mohammadi H, Zobeiri M, Clark CCT · Int J Clin Pract (2021)
2Neuroprotective effects against aflatoxin-induced neurotoxicityÜbersicht2025
Einfach gesagt: This review focuses on the molecular pathways through which AFs exert neurotoxic effects, highlighting their role in the onset of neurodegenerative diseases and potential neuroprotective compounds for therapies have been highlighted.
Elangovan A et al. · Journal of applied toxicology : JAT (2025)
Mounting evidences suggests that these factors trigger neurological disorders especially neurodegenerative disorders.
Neuroprotective compounds, such as hesperetin, N-acetylcysteine (NAC), curcumin, and artichoke extract, have shown promise in counteracting AF-induced neurotoxicity.
These compounds could reduce oxidative stress, attenuate inflammation, and support mitochondrial function, offering potential therapeutic strategies to mitigate AF-induced neurodegeneration.
Einfach gesagt: Artichoke supplementation may offer modest but significant improvements in several cardiometabolic risk markers.
Jafari A et al. · Diabetes & metabolic syndrome (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Blood pressure outcomes revealed significant reductions in both systolic (WMD = -2.49 mmHg, 95 % CI: 4.33 to -0.65) and diastolic (WMD = -1.53 mmHg, 95 % CI: 3.01 to -0.05) pressures.
Regarding glycemic indices, insulin (WMD = -1.83 mU/L, 95 % CI: 3.33 to -0.32) and homeostatic model assessment for insulin resistance (WMD = -0.92, 95 % CI: 1.33 to -0.51) were significantly reduced, whereas fasting blood glucose and HbA1c were unaffected.
Among liver function markers, alanine aminotransferase (WMD = -8.47 U/L, 95 % CI: 14.71 to -2.23) and alkaline phosphatase (WMD = -7.86 U/L, 95 % CI: 15.26 to -0.45) were significantly reduced, while aspartate aminotransferase showed a borderline non-significant effect.
8HDL-C concentrationsMeta-Analysen=702 · large study2018
Einfach gesagt: Thus, supplementation with artichoke extract was associated with a significant reduction in both total and LDL-C, and triglycerides, suggesting that supplementation may be synergistic with lipid-lowering therapy in patients with hyperlipidemia.
Sahebkar A et al. · Critical reviews in food science and nutrition (2018)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Could be chance
Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics.
No significant alteration in plasma High Density Lipoprotein-Cholesterol (HDL-C) concentrations was observed (WMD: 1.0 mg/dL, 95%CI: -1.1, 3.1, p = 0.333).
A significant association between the LDL-lowering effect of artichoke and baseline LDL-C concentrations (slope: -0.170; 95%CI: -0.288, 0.051; p = 0.005) was observed.
9Nutritional profiles and pharmacological effectsÜbersicht2024
Einfach gesagt: The current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.
Porro C et al. · Nutrients (2024)
This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases.
Additionally, these polyphenols demonstrate anti-inflammatory activity, which is closely associated with their antioxidant properties.
As a result, C. scolymus has the potential to contribute to the treatment of chronic diseases, including intestinal disorders, cardiovascular diseases, and neurodegenerative pathologies.
Bjørklund G et al. · Current pharmaceutical design (2024)
Among medicinal plants with substantial detoxifying properties, a major part belongs to the Asteraceae family (Silybum marianum, Cynara scolymus, Arctium lappa, Helichrysum species, Inula helenium, and Taraxacum officinale).
The most widely used hepatoprotective phytocomponent is silymarin, a standardized extract from the Silybum marianum seeds containing a mixture of flavonolignans.
Many polysaccharides, polyphenols, and terpenoids have a detoxifying effect.
Einfach gesagt: The following natural ingredients - red yeast rice, artichoke extract, bergamot, garlic, and flaxseed - have been specifically selected for their cholesterol-lowering properties.
von Känel-Cordoba I et al. · Journal of health, population, and nutrition (2024)
The following natural ingredients - red yeast rice, artichoke extract, bergamot, garlic, and flaxseed - have been specifically selected for their cholesterol-lowering properties.
This is important due to the varying effectiveness of alternative treatments.
However, there are lingering concerns regarding the lack of supervision and quality control that require attention. (2) Further research into the specific molecular composition and the underlying mechanisms by which it reduces cholesterol levels is warranted.
Einfach gesagt: More clinical trials are required before new natural compounds and herbs can be used to treat chronic hypertension and its ramifications, such as respiratory distress syndrome and kidney failure.
Khaled A et al. · Phytotherapy research : PTR (2023)
Alkaloids, amino acids, anthocyanidins, flavonoids, glucosinolates, isoflavonoids, phenolic acids, polyphenolics, and triterpenoids are among the bioactive metabolites pocessing an impressive ACE inhibitory activity.
Many herbs including Rosmarinus officinalis, Hibiscus sabdariffa, Curcuma longa, Rauwolfia serpentina, Emblica officinalis, Cynara scolymus, Punica granatum, Mucuna pruriens, Capsicum annuum, and Moringa olifera were found having ACE inhibitory activities comparable to captopril and enalpril.
These enticing natural ACE inhibitors deserve to be a safeguard medicine against hypertension, respiratory distress syndrome, and chronic kidney diseases.
13Diabetes and prediabetes managementSystematische Übersicht2024
Einfach gesagt: Further studies are also required for Cinnamomum, Cynara scolymus, Momordica charantia, Olea europaea, and Opuntia streptacantha.
Derosa G et al. · Phytotherapy research : PTR (2024)
The available evidence showed promising hypoglycemic effects of the nutraceuticals reviewed both for their efficacy and safety profile.
Further studies are also required for Cinnamomum, Cynara scolymus, Momordica charantia, Olea europaea, and Opuntia streptacantha.
Moreover, well-designed large and long-term clinical trials including the use of standardized nutraceutical preparations are necessary for Phaseolus vulgaris and Vaccinium myrtillus.
Einfach gesagt: The available data support the use of standardized compositions of artichoke and bergamot extracts, alone or in combination, in the treatment of mild to moderate dyslipidemia, in patients suffering from metabolic syndrome, hepatic steatosis, or intolerant to common hypolipidemic treatments.
Arnaboldi L et al. · Minerva medica (2022)
An approach also shared by the European Atherosclerosis Society (EAS).
In light of these evidence, this review aimed to describe the effects of artichoke and bergamot in modifying the lipid and inflammatory parameters described in in vitro, in vivo and clinical studies.
The available data support the use of standardized compositions of artichoke and bergamot extracts, alone or in combination, in the treatment of mild to moderate dyslipidemia, in patients suffering from metabolic syndrome, hepatic steatosis, or intolerant to common hypolipidemic treatments.
Einfach gesagt: Many people use herbal and traditional remedies for the treatment of disorders such as gastrointestinal disorders, especially in Asian countries.
Azimi M et al. · Current drug discovery technologies (2021)
Many people use herbal and traditional remedies for the treatment of disorders such as gastrointestinal disorders, especially in Asian countries.
Several studies reported the efficacy of herbal medicine in functional dyspepsia.
Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD.
Einfach gesagt: Awareness of the widespread use of complementary and alternative medicine by people with metabolic disorders is crucial for healthcare professionals in order to prevent cardiovascular disease.
Rondanelli M et al. · Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace (2013)
This review enumerates the most significant studies that have highlighted these therapeutic properties.
Complementary medicine information needs to be incorporated into clinical practice and patient and professional education, in addition to adequate education about proper nutrition.
Awareness of the widespread use of complementary and alternative medicine by people with metabolic disorders is crucial for healthcare professionals in order to prevent cardiovascular disease.
17Digestive and cardiovascular healthÜbersicht2015
Einfach gesagt: This article intended to review the wide ranging pharmacological effects of artichoke leaf extract.
Ben Salem M et al. · Plant foods for human nutrition (Dordrecht, Netherlands) (2015)
Although research is not yet conclusive, scientists were optimistic that its long-standing use in humans for digestive and bowel problems was indeed justified.
It may also play a role in lowering cholesterol and thus help to prevent heart disease.
Boiled wild artichoke reduced postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients.
18Atherosclerosis and liver disease treatmentÜbersicht2012
Einfach gesagt: His multidirectional treatment is a documented fact and it is associated with treatment of dyspepsia, influence of active substances contained in artichoke on plasma lipid levels and with a strong antioxidant effect of the artichoke extract--due to this properties, artichoke compounds have a protective effect on liver cells.
Horoszkiewicz M et al. · Przeglad lekarski (2012)
Substances of natural origin are the subject of growing interest on the part of both researchers and doctors.
One of the well known herbal medicines extensively examined in terms of clinical and pharmacological is artichoke (Cynara scolymus L.), which was used in European medicine from the 18th century.
Further research warranted to confirm findings
19Lipid profile changesÜbersicht2018
Einfach gesagt: Evidence suggests that decreases of 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides, can be attributed to 2 to 3 g/d of ALE, in which its comp...
Santos HO et al. · Pharmacological research (2018)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Evidence suggests that decreases of 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides, can be attributed to 2 to 3 g/d of ALE, in which its components luteolin and chlorogenic acid may play a key role.
On the other hand, the effects of cooked artichoke hearts can be attributed mainly to its soluble fibres, particularly inulin.
Despite the convincing evidence on its health benefits, additional long-term clinical trials are pivotal to fully elucidate the potential effects of ALE administration on positive cardiovascular outcomes.
20Antioxidant function for ageing-related disordersÜbersicht2018
Einfach gesagt: A systematic overview of the relevant information in the antioxidant function of the many herbal products reviewed here for the control of the ageing process is proposed, to provide a new horizon on the design of anti-ageing herbal medicines.
Bjørklund G et al. · Basic & clinical pharmacology & toxicology (2018)
A much more complex ability to interact with survival functions makes these compounds successfully active in preventing ageing-related disorders.