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Bbr7.5
Berberine – Forschung
Hilft wahrscheinlich
213 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Berberine scheint in 12 von 14 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1985–2027 mit einer typischen Studiengröße von 553 Teilnehmenden.
Basierend auf 213 Studien · 41 Meta-Analysen · 78 RCTs · 55,130 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
12geholfen2unklar· 199 weitere ohne bewertete Effektdaten
Cholesterol & lipidsVerbessert Lipidprofile und Blutzuckermarker · 8-12 Wochen
Hilft wahrscheinlich21 Studien
Digestive healthModuliert das Darmmikrobiom und unterstützt die gastrointestinale Funktion · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung19 Studien
Safety profile
Hilft wahrscheinlich18 Studien
Women's healthUnterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung16 Studien
Liver health
Gemischte Evidenz14 Studien
Heart & blood pressureVerbessert Lipidprofile und Blutzuckermarker · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung11 Studien
Weight managementVerbesserter Fettstoffwechsel und Körperzusammensetzung · 4-12 Wochen
Hilft vermutlich10 Studien
InflammationSignifikante Verbesserungen des Blutzuckers und der Blutfette · 4-12 Wochen
Überwiegend Mechanismus / Beobachtung10 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung8 Studien
In Zahlen
Aus 58 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
78%
über Studien hinweg
Untersuchte Personen
55k
typische Studie: 553 Personen
Stärkste Designs
119
41 gepoolt, 78 randomisiert
Zeigte Nutzen
86%
12/14 Studien
Wie lange Studien liefen
1–4 Wochen
2
1–3 Monate
4
3+ Monate
1
Untersuchte Populationen
Type 2 diabetes patients4
Cardiovascular disease patients2
NAFLD patients2
Patients with Type 2 Diabetes Mellitus1
Aktives Forschungsgebiet
150 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
198520062027
1HbA1c reductionMeta-Analysen=1,337 · large study2025
Einfach gesagt: However, further validation of these findings is necessary through extensive clinical studies with larger sample sizes.
Miao R et al. · Phytotherapy research : PTR (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Borderline
For HbA1c, silymarin was more effective than resveratrol (MD -2.08, 95%Cl -3.50 to -0.72) (P < 0.05).
For body mass index (BMI), curcumin was more effective than resveratrol (MD -1.27, 95%Cl -2.43 to -0.03) (P < 0.05).
Curcumin, resveratrol, silymarin, and berberine can effectively improve cardio-metabolic risk factors in T2DM, and different herbal phytochemicals have different clinical advantages.
3Inflammatory biomarkers reductionMeta-Analysen=1,600 · large study2023
Einfach gesagt: However, more investigation and high-quality evidence must be conducted to obtain more comprehensive and generalizable results.
Vahedi-Mazdabadi Y et al. · Phytotherapy research : PTR (2023)
In addition, the non-linear analysis showed a significant lowering effect of berberine/barberry on IL-6 and TNF-α levels in doses <1000 mg/day and less than 5 weeks of intervention.
There are limitations to our findings, including low-quality studies and significant heterogeneity.
These interventions might be considered adjunct therapy to managing inflammation status.
Einfach gesagt: This study suggests that berberine may be a promising alternative for CVDs with no serious adverse reactions.
Yang L et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2023)
Berberine alone significantly reduced National Institute of Health Stroke Scale (NIHSS) score, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and intima-media thickness (IMT) levels than routine therapy.
Berberine plus statins significantly reduced TC, TG, LDL-C, NIHSS score, hs-CRP, TNF-α, IMT, Crouse score, and number of unstable plaques levels than routine or statins.
This study suggests that berberine may be a promising alternative for CVDs with no serious adverse reactions.
5Glycemic control improvementMeta-Analysen=5,000 · very large study2024
Einfach gesagt: The finding of our umbrella showed that the supplementation of BBR could be effective in improving glycemic parameters and inflammatory marker in adults.
Einfach gesagt: Higher quality studies are needed to provide more high quality evidence.
Zhang LS et al. · The American journal of Chinese medicine (2019)
The results of meta-analysis showed that compared with the placebo group, berberine could significantly reduce the total cholesterol and low-density lipoprotein levels and elevate the high density lipoprotein level ( P<0.05 ).
Compared with the simvastatin group, berberine was effective only in reducing the level of triglyceride ( MD=-0.37 , 95% CI: - 0.66, - 0.07, P=0.02 ).
Compared with the simvastatin group, berberine plus simvastatin was more effective in reducing the level of triglyceride ( MD=-0.33 , 95% CI: - 0.46, - 0.20, P<0.00001 ) and total cholesterol ( MD=-0.36 , 95% CI: - 0.60, - 0.12, P=0.003 ).
Einfach gesagt: The dosage and treatment duration of Berberine and patients' age may modify the effect.
Liang Y et al. · Endocrine journal (2019)
We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and glycated haemoglobin (HbA1c) levels.
The pool data showed that Berberine treatment was associated with a better reduction on FPG (WMD = -0.54 mmol/L, 95% CI: -0.77 to -0.30), PPG (WMD = -0.94 mmol/L, 95% CI: -1.27 to -0.61), and HbA1c (WMD = -0.54 mmol/L, 95% CI: -0.93 to -0.15) than control groups.
Subgroup-analyses indicated that effects of Berberine on blood glucose became unremarkable as the treatment lasted more than 90 days, the daily dosage more than 2 g/d and patients aged more than 60 years.
Einfach gesagt: This study indicates that berberine has comparable therapeutic effect on type 2 DM, hyperlipidemia and hypertension with no serious side effect.
Lan J et al. · Journal of ethnopharmacology (2015)
This study indicates that berberine has comparable therapeutic effect on type 2 DM, hyperlipidemia and hypertension with no serious side effect.
Considering the relatively low cost compared with other first-line medicine and treatment, berberine might be a good alternative for low socioeconomic status patients to treat type 2 DM, hyperlipidemia, hypertension over long time period.
Due to overall limited quality of the included studies, the therapeutic benefit of berberine can be substantiated to a limited degree.