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Bgm6.5
Bergamot – Forschung
Hilft wahrscheinlich
45 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Bergamot sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2011–2026 mit einer typischen Studiengröße von 90 Teilnehmenden.
Basierend auf 45 Studien · 4 Meta-Analysen · 30 RCTs · 10,348 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen· 43 weitere ohne bewertete Effektdaten
Nach Outcome
Cholesterol & lipidsVerbesserte Cholesterinverhältnisse und kardiovaskuläre Marker innerhalb von 4-8 Wochen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung38 Studien
Weight management
Überwiegend Mechanismus / Beobachtung9 Studien
InflammationSignifikante Senkung von LDL und Triglyzeriden · 4-12 weeks
Überwiegend Mechanismus / Beobachtung8 Studien
Heart & blood pressureVerbesserte Cholesterinverhältnisse und kardiovaskuläre Marker innerhalb von 4-8 Wochen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Liver health
Überwiegend Mechanismus / Beobachtung6 Studien
Anxiety & stress
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Glucose & metabolicVerbessert das Lipidprofil und metabolische Marker · 8-12 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Sleep & insomnia
Zu wenige bewertete Studien2 Studien
Therapeutic & clinical
Zu wenige bewertete Studien2 Studien
Depression & mood
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 21 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
10k
typische Studie: 90 Personen
Stärkste Designs
34
4 gepoolt, 30 randomisiert
Zeigte Nutzen
100%
2/2 Studien
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
4
3+ Monate
1
Untersuchte Populationen
Patients with moderate hyperlipidemia1
Dyslipidemic subjects1
individuals with mild dyslipidemia1
cancer patients1
Aktives Forschungsgebiet
31 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
201120182026
1Meta-Analyse2022
Sadeghi-Dehsahraei H, Esmaeili Gouvarchin Ghaleh H, Mirnejad R, Parastouei K · Phytother Res (2022)
Einfach gesagt: Promising findings reveal an alternative therapeutic option in dyslipidemia management with bergamot supplementation, especially in subjects with statins intolerance.
Lamiquiz-Moneo I et al. · Critical reviews in food science and nutrition (2020)
Although statins can reduce LDLc by 50-60%, less than 20% of patients with high risk of CVD achieve LDL targets.
Based on data, 75% of studies showed a significant decrease in total cholesterol, triglycerides and LDLc.
The decrease in total cholesterol varied from 12.3% to 31.3%, from 7.6% to 40.8% in LDLc and from 11.5% to 39.5% in triglycerides.
4Plasma lipids and lipoprotein profileSystematische Übersicht2017
Einfach gesagt: Supplementation with polyphenols from bergamot juice reduces plasma lipids and improves lipoprotein profile in moderate hyperlipidemia.
Mannucci C et al. · Phytotherapy research : PTR (2017)
Supplementation with polyphenols from bergamot juice reduces plasma lipids and improves lipoprotein profile in moderate hyperlipidemia.
Effectiveness and safety of C. bergamia cannot be definitively drawn because of publication bias and low quality level of the majority of studies.
Further large-scale trials with rigorous design are required to define the role of C. bergamia in clinical practice.
Einfach gesagt: Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.
Rondanelli M et al. · BioMed research international (2016)
The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels.
Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.
Einfach gesagt: This review summarizes the mechanisms of action and available clinical evidence and outlines potential indications for bergamot use in selected patient subgroups.
Carpenito M, Coletti F, Muscoli S, Guarino L, Di Cristo A, Cammalleri V, Mega S, Emerenziani S, Cicala M, Fanali C, Ussia GP, Grigioni F. · Nutrients (2025)
Derived from food sources, they represent a promising adjunctive or alternative therapeutic option in specific clinical contexts, particularly in individuals with mild dyslipidemia or those who fail to achieve lipid targets despite optimal pharmacological treatment.
Bergamot-alongside its lipid-lowering effects-has demonstrated multiple additional properties, including anti-inflammatory, antioxidant, and vascular benefits.
While lipid effects are supported by several clinical studies, evidence for vascular and inflammatory pathways is based mainly on preclinical studies.
Einfach gesagt: To summarize, this review suggests that the Mediterranean Diet and nutraceutical supplements may help prevent and manage cancer, but more research is needed to confirm their benefits.
Altomare C, Macrì R, Serra M, Ussia S, Ritorto G, Maiuolo J, Muscoli C, Perri E, Mollace V. · Nutrients (2025)
Promising results show that key compounds such as bergamot polyphenolic fraction (BPF), cynaropicrin, oleuropein, quercetin, resveratrol, and serotonin can modulate oxidative stress, inflammation, the tumor microenvironment, the cell cycle, and drug resistance.
A significant observation is that many of these substances demonstrate dual dose-dependent activity; they function as antioxidants in healthy cells but induce pro-oxidant and pro-apoptotic effects in cancerous cells.
Their ability to boost chemotherapy's effectiveness and safety while lessening side effects and offering combined advantages is also explored.
Einfach gesagt: Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.
Russo C, Lombardo GE, Bruschetta G, Rapisarda A, Maugeri A, Navarra M. · Nutrients (2024)
Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas.
Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives.
Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field.
Einfach gesagt: Preclinical data suggest that polyphenols are potent multifunctional agents capable of breaking the feedback loops of cardiorenal injury.
Carollo C et al. · Nutrients (2026)
Preclinical data suggest that polyphenols are potent multifunctional agents capable of breaking the feedback loops of cardiorenal injury.
While bioavailability remains a significant translational challenge, novel nano-delivery systems and synthetic analogs offer promising strategies for clinical application.
Integrating these bioactives into CRS management could provide a decisive adjunctive strategy to improve metabolic homeostasis and prevent end-stage organ failure.
10Cardiometabolic risk factorsRCTn=90 · small study2024
Einfach gesagt: Overall, these findings support the use of the tested dietary supplement containing dry extracts of bergamot and artichoke as a safe and effective approach for the prevention and management of a broad spectrum of cardiometabolic disorders.
Fogacci F et al. · Nutrients (2024)
Borderline
After 6 weeks, the active-treated group experienced significant improvements in levels of triglycerides (TG), apolipoprotein B-100 (Apo B-100), and apolipoprotein AI (Apo AI) versus baseline.
Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (Non-HDL-C), and hs-CRP also significantly decreased in the active-treated group compared to both baseline and placebo.
Improvements in TC, LDL-C, Non-HDL-C, TG, fatty liver index (FLI), hs-CRP, and endothelial reactivity were also detected compared to placebo (p < 0.05 for all).