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Bt2.0
Beta-Carotin – Forschung
Überwiegend Mechanismus / Beobachtung
5 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Beta-Carotin sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1994–2026 mit einer typischen Studiengröße von 29,133 Teilnehmenden.
Basierend auf 5 Studien · 1 Meta-Analyse · 2 RCTs · 47,447 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Therapeutic & clinical
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Cholesterol & lipids
Zu wenige bewertete Studien1 Studie
Men's vitality
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
2 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2012
199420102026
1RCTn=29,133 · very large study1994
Einfach gesagt: Among 29,133 male smokers, beta-carotene supplementation unexpectedly increased lung cancer incidence by 18% and total mortality by 8%.
Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group · N Engl J Med (1994)
Lung cancer incidence with beta-carotene: +18% (95% CI 3% to 36%) compared with those not receiving it — an unexpected harm
Total mortality was 8% higher (95% CI 1% to 16%) with beta-carotene, primarily from lung cancer and ischaemic heart disease
Alpha-tocopherol showed no reduction in lung cancer (-2%, 95% CI -14% to 12%) and more deaths from haemorrhagic stroke, though fewer prostate cancers
Einfach gesagt: The Beta-Carotene and Retinol Efficacy Trial was stopped 21 months early after beta-carotene plus retinol raised lung cancer risk by 28% in smokers, former smokers and asbestos-exposed workers.
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S · N Engl J Med (1996)
Lung cancer relative risk in the active-treatment group: 1.28 (95% CI 1.04-1.57, P=0.02) versus placebo
Relative risk of death from any cause 1.17 (95% CI 1.03-1.33); from lung cancer 1.46 (1.07-2.00); from cardiovascular disease 1.26 (0.99-1.61)
The trial was stopped 21 months earlier than planned because of these findings
Einfach gesagt: We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality.
Einfach gesagt: Sunless tanning agents offer UV-free alternatives for cosmetic pigmentation but are not without risk.
Resnick G, Khajeh-Afzaly M, Yousefian F, Raza A, Issa NT · J Clin Aesthet Dermatol (2026)
Reviewed the mechanisms, uses and adverse effects of self-tanning agents including DHA, melanotan and carotenoids
Carotenoids taken orally accumulate in skin and subcutaneous fat, creating a yellow-orange hue
Groups carotenoids as an alternative pigmentation pathway rather than an equivalent to melanin
5Übersicht2024
Einfach gesagt: In carotenodermia associated with high β-carotene intake the discoloration tends to be widespread, mainly in thick areas of the skin (e.g., the palm of the hand), and can last from 14 days to 4.5 years.
Kapsetaki ME · Int J Dermatol (2024)
Reviewed roughly 100 published human cases of carotenodermia from high beta-carotene intake
Discolouration is widespread and concentrated in thick skin such as the palms
Duration ranged from 14 days to 4.5 years after intake stopped