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Bs7.5
Beta-Sitosterol – Forschung
Hilft wahrscheinlich
72 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Beta-Sitosterol scheint in 4 von 4 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1976–2026 mit einer typischen Studiengröße von 519 Teilnehmenden.
Basierend auf 72 Studien · 10 Meta-Analysen · 52 RCTs · 39,631 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen· 68 weitere ohne bewertete Effektdaten
Nach Outcome
Cholesterol & lipidsReduziert die LDL-Cholesterinaufnahme um 10-15% · 4-8 weeks
Hilft wahrscheinlich62 Studien
BPH & lower urinary tract symptoms
Überwiegend Mechanismus / Beobachtung10 Studien
InflammationModerate Senkung des LDL-Cholesterins · 4-6 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Men's vitalityVerbesserung der BPH-Symptome · 4-8 weeks
Zu wenige bewertete Studien1 Studie
Heart & blood pressureReduziert die LDL-Cholesterinaufnahme um 10-15% · 4-8 weeks
Zu wenige bewertete Studien1 Studie
Therapeutic & clinical
Zu wenige bewertete Studien1 Studie
Immune support
Zu wenige bewertete Studien1 Studie
Weight management
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 22 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
40k
typische Studie: 519 Personen
Stärkste Designs
62
10 gepoolt, 52 randomisiert
Zeigte Nutzen
100%
4/4 Studien
Wie lange Studien liefen
1–4 Wochen
2
Untersuchte Populationen
General population2
Men with benign prostatic hyperplasia2
Adults2
Healthy adults2
Stetige Forschung
14 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
197620012026
1Asthma treatment effectivenessMeta-Analysen=1,200 · large study2025
Einfach gesagt: QJWJ is effective in the treatment of asthma, and the therapeutic mechanism may be related to its regulation of inflammation, immunity, and apoptosis.
Zhang L et al. · Medicine (2025)
QJWJ is effective in the treatment of asthma, and the therapeutic mechanism may be related to its regulation of inflammation, immunity, and apoptosis.
3Gouty arthritis treatment effectivenessMeta-Analysen=7,151 · very large study2024
Einfach gesagt: TCMD could be a satisfactory complementary and alternative therapy for GA.
Qu P et al. · Medicine (2024)
TCMD could be a satisfactory complementary and alternative therapy for GA.
However, it should be verified by further studies.
Future research could be conducted from the following active ingredients, targets, and signal pathways, such as wogonin, sitosterol, and sitosterol; AKT1, TNF, IL6, and TP53; and IL-17, HIF-1, and PI3K-AKT signaling pathway.
4Serum levels of campesterolMeta-Analysen=9,758 · very large study2024
Einfach gesagt: This meta-analysis examined the effects of Beta-Sitosterol.
Alenbawi J et al. · Human genomics (2024)
The meta-analysis replicated most of the reported variants, and our study provided significant support for the association of variants in SCARB1 and ABO with sitosterolemia.
Evaluation of a polygenic risk score devised from European GWAS data showed moderate performance when applied to QBB (adjusted-R2 = 0.082).
These findings provide new insights into the genetic architecture of phytosterol metabolism while showing the importance including under-represented populations in future GWAS studies.
Einfach gesagt: This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Ulbricht CE · Journal of dietary supplements (2016)
An evidence-based systematic review of beta-sitosterol, sitosterol (22,23-dihydrostigmasterol, 24-ethylcholesterol) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale.
This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
12Antidiabetic activity of natural compoundsSystematische Übersicht2018
Einfach gesagt: This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.
Munhoz ACM et al. · Current diabetes reviews (2018)
This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.
Einfach gesagt: It also notes gaps in current knowledge, underscoring the need for well-designed translational studies and randomized clinical trials to determine proper dosing, safety, and long-term effectiveness before these compounds can be fully used in clinical practice.
Shah FI et al. · Reproductive sciences (Thousand Oaks, Calif.) (2026)
Emphasizing their mechanistic actions, the review highlights targeting the CYP17A1–AR signaling axis and the AMPK–GLUT4 metabolic pathway, key intersections between endocrine disturbances and metabolic dysregulation.
It also notes gaps in current knowledge, underscoring the need for well-designed translational studies and randomized clinical trials to determine proper dosing, safety, and long-term effectiveness before these compounds can be fully used in clinical practice.
16Anticancer mechanisms of plant sterolsÜbersicht2026
Einfach gesagt: The unique contribution of this review lies in proposing a comparative mechanistic framework for stigmasterol, campesterol, and β-sitosterol, integrating their multi-targeted actions across key oncogenic signaling pathways to highlight their collective potential in anticancer therapy.
Menaga S et al. · Cell biochemistry and function (2026)
Despite extensive individual studies, a comprehensive review summarizing their collective anticancer mechanisms is lacking.
This work bridges that gap by systematically analyzing literature from the past 10 years across major databases, including Google Scholar, ScienceDirect, Scopus, Wiley Online Library, and Web of Science.
Evidence from preclinical, clinical, and pharmacological studies was critically evaluated to highlight the therapeutic potential of these sterols in tumor suppression and apoptosis, providing a consolidated foundation for future drug discovery and development.
18LDL cholesterol levelsRCTn=109 · medium study2024
Einfach gesagt: These findings support the efficacy of United Kingdom SFA dietary guidelines for the overall lowering of serum LDL cholesterol but showed marked variation in LDL cholesterol response.
Koutsos A et al. · The American journal of clinical nutrition (2024)
Likely real
There was also an increase in plasma biomarkers of cholesterol intestinal absorption (β-sitosterol, campesterol, cholestanol), and synthesis (desmosterol) (P < 0.0001) and fold change in PBMC LDL-receptor mRNA expression relative to the higher-SFA/lower-UFA diet (P = 0.035).
These findings support the efficacy of United Kingdom SFA dietary guidelines for the overall lowering of serum LDL cholesterol but showed marked variation in LDL cholesterol response.
Further identification of the determinants of this variation will facilitate targeting and increasing the efficacy of these guidelines.