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Bio5.0
Biotin – Forschung
Hilft vermutlich
38 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Biotin half in etwa der Hälfte (5/8) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1989–2026 mit einer typischen Studiengröße von 82 Teilnehmenden.
Basierend auf 38 Studien · 6 Meta-Analysen · 19 RCTs · 9,683 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
5geholfen2unklar1nicht geholfen· 30 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Hilft vermutlich36 Studien
Hair, nails & skin
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung4 Studien
Women's healthEssenzielles B-Vitamin, häufig in Präparaten für Schwangere enthalten; beugt einem Mangel vor · Ongoing
Überwiegend Mechanismus / Beobachtung3 Studien
Neuroprotection & brain aging
Zu wenige bewertete Studien1 Studie
Energy & fatigue
Zu wenige bewertete Studien1 Studie
Inflammation
Zu wenige bewertete Studien1 Studie
Skin healthAlte, kleine, unkontrollierte Studien deuten auf festere brüchige Nägel hin; kein Nutzen für das Haar ohne Mangel · 3-6 months
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 16 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
9,683
typische Studie: 82 Personen
Stärkste Designs
25
6 gepoolt, 19 randomisiert
Zeigte Nutzen
63%
5/8 Studien
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
1
3+ Monate
4
Untersuchte Populationen
Progressive multiple sclerosis patients3
Optic neuritis patients1
Primary progressive multiple sclerosis patients1
Multiple sclerosis patients1
Aktives Forschungsgebiet
20 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
198920072026
1Retinal nerve fiber layer thicknessMeta-Analysen=2,465 · very large study2025
Einfach gesagt: Although meta-analysis showed no significant effect of vitamins A, B1, B6, B7, B12, and D on several visual parameters, improvements observed in individual studies point to the essential role of vitamin sufficiency in ON.
Gaffney PJ et al. · Multiple sclerosis and related disorders (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Borderline
The effect of MD1003 (high-dose biotin), vitamin A, and vitamin D on retinal nerve fiber layer (RNFL) thickness from pooled results showed a mean change of 0.15 (SMD 0.15, 95 % CI, -0.33 to 0.64, I2 = 61 %, τ² = 0.11, p = 0.08), which was not significant.
Meta-analysis of visual acuity due to MD1003 and vitamin A from two studies showed a mean change of 0.01 (SMD 0.01, 95 % CI, -0.34 to 0.35, I2 = 0 %, τ² = 0, p = 0.36).
Significant improvements in RNFL thickness due to vitamin A, visual acuity due to vitamins B1, B6, and B12, foveal sensitivity due to vitamins B1, B6, and B12, and the rate of conversion of ON to MS due to vitamin D were observed in individual studies.
2Confirmed disability progression (wCDP%)Meta-Analysen=3,779 · very large study2023
Einfach gesagt: The results of this study provide the necessary quantitative information for both the rational clinical use of drugs and future clinical trials in primary progressive multiple sclerosis.
Sui Z et al. · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2023)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Among these, ocrelizumab showed outstanding performance, with wCDP% of 72.6 at 96 weeks, while the proportions of rest of the drugs ranged between approximately 55-70%.
The results of this study provide the necessary quantitative information for both the rational clinical use of drugs and future clinical trials in primary progressive multiple sclerosis.
3ITW25 improvementMeta-Analysen=830 · large study2021
Einfach gesagt: A moderate certainty of evidence suggests a potential benefit in favor of HDB administered for 12 to 15 months in terms of ITW25 in patients with PMS.
Espiritu AI et al. · Multiple sclerosis and related disorders (2021)
Sehr groß Schaden
← SchlechterKein EffektBesser →
Pooled data for ITW25 at 12 to 15 months yielded statistical significance (RR 2.06; 95% CI 1.04-4.09; 2 trials; 796 participants; I2 = 0%) [moderate COE] favoring HDB among patients with PMS.
At 12 to 15 months, no significant differences were found in terms of mean change in EDSS (MD -0.06; 95% CI -0.14-0.02; 2 studies; 796 participants; 889 participants; I2 = 68%) among patients with PMS.
Synthesized data on incidence of any AEs (RR 0.98; 95% CI 0.92-1.04; 3 trials; I2 = 0%) [high COE] and any serious AEs (RR 0.98; 95% CI 0.77-1.24; 3 trials; 889 participants; I2 = 0%) [moderate COE] were not significantly different between HDB and placebo groups.
4Global impression of deteriorationMeta-Analysen=217 · medium study2020
Einfach gesagt: There are a variety of controlled trials addressing the effects of dietary interventions for MS with substantial variation in active treatment, comparator, and outcomes of interest.
Parks NE et al. · The Cochrane database of systematic reviews (2020)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Among four trials comparing PUFAs with MUFAs, there may be little to no difference in global impression of deterioration (RR 0.85, 95% CI 0.71 to 1.03; 4 studies, 542 participants; 40% in the PUFA group versus 47% in the MUFA group; low-certainty evidence).
In two trials comparing different PUFAs (omega-3 versus omega-6), there may be little to no difference in relapses (RR 1.02, 95% CI 0.62 to 1.66; 2 studies, 129 participants; 30% in the omega-3 versus 29% in the omega-6 group; low-certainty evidence).
Among three trials comparing omega-3 with omega-6, there may be little to no difference in change in disability progression, measured as mean change in Expanded Disability Status Scale (EDSS) (mean difference (MD) 0.00, 95% CI -0.30 to 0.30; 3 studies, 166 participants; low-certainty evidence).
Einfach gesagt: High quality data on the efficacy of nutritional (vitamins-minerals) supplementations in treating seizures in PWE is scarce; however, designing future clinical trials of polyunsaturated fatty acid supplementation for drug-resistant seizures in adults with focal epilepsy and in children, and also multivitamin supplementations in adults with focal epilepsy seems reasonable and promising.
Asadi-Pooya AA et al. · Clinical nutrition (Edinburgh, Scotland) (2021)
Such clinical trials should be well-designed, randomized, and placebo controlled, with enough sample size and adequate follow-up of 12 months or more.
Einfach gesagt: The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS.
Marx W et al. · Multiple sclerosis and related disorders (2020)
The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS.
However, sufficiently powered long-term trials are required to expand the currently limited literature and to investigate unexplored nutraceuticals that may target relevant pathways involved in MS such as the gut microbiome and mitochondrial dysfunction.
Einfach gesagt: In this review, we summarize the current knowledge on the molecular aspects of biotin and associated molecules in diseases related to both acute inflammatory responses and chronic inflammation, and discuss the potential therapeutic applications of biotin.
Sakurai-Yageta M, Suzuki Y. · Nutrients (2024)
These regulatory roles in metabolic and immune homeostasis connect biotin to conditions such as diabetes, dermatologic manifestations, and multiple sclerosis.
Furthermore, deficiencies in biotin and SMVT are implicated in inflammatory bowel disease, affecting intestinal inflammation, permeability, and flora.
Notably, HCS and probably biotin directly influence gene expression through histone modification.
Einfach gesagt: In this review article, recent findings/advancements that may offer new insight in the abovementioned research fields concerning biotin will be presented and briefly discussed.
Karachaliou CE, Livaniou E. · International journal of molecular sciences (2024)
On the other hand, according to warnings of the Food and Drug Administration, USA, high biotin levels can affect clinical biotin-(strept)avidin assays and thus lead to false results during quantification of critical biomarkers.
In this review article, recent findings/advancements that may offer new insight in the abovementioned research fields concerning biotin will be presented and briefly discussed.
Einfach gesagt: This review focuses on the role of biotin in allergic reactions, both as a causative factor (allergen/hapten), a factor predisposing to the development of sensitization to various allergens, and an interfering factor in immunochemical methods used in laboratory diagnosis of hypersensitivity reactions and how it can be prevented.
Lis K. · Nutrients (2025)
Biotin is also used as an element of some methodological models in immunochemical tests (in vitro diagnostics), including methods used to measure the concentration of immunoglobulin E (IgE), both total (tIgE) and allergen-specific (sIgE).
For this reason, vitamin B7 supplementation can be a significant interfering factor in some immunochemical tests, which can lead to false laboratory test results, both false positive and false negative, depending on the test format.
This situation can have a direct impact on the quality and effectiveness of diagnostics in various clinical situations, including allergy diagnostics.
11Disability progressionRCTn=642 · large study2020
Einfach gesagt: This study showed that MD1003 did not significantly improve disability or walking speed in patients with progressive multiple sclerosis and thus, in addition to the potential of MD1003 for deleterious health consequences from interference of laboratory tests, MD1003 cannot be recommended for treatment of progressive multiple sclerosis.
Cree BAC et al. · The Lancet. Neurology (2020)
642 participants randomized to MD1003 (oral biotin 100 mg three times daily) or placebo
For the primary outcome, 39 (12%) of 326 in the MD1003 group versus 29 (9%) of 316 in the placebo group improved at month 12 (odds ratio 1.35 [95% CI 0.81-2.26])
MD1003 did not significantly improve disability or walking speed versus placebo
17CLOCK gene expression changesRCTn=53 · small study2024
Einfach gesagt: Changing the gut microbiome by probiotic treatment potentially influences CLOCK gene expression.
Kreuzer K et al. · Neuropsychobiology (2024)
Changing the gut microbiome by probiotic treatment potentially influences CLOCK gene expression.
The preliminary results of the PROVIT-CLOCK study indicate a possible interconnection between the gut microbiome and circadian rhythm potentially orchestrated by metabolites.