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Bon3.5
Bonito Peptides – Forschung
Überwiegend Mechanismus / Beobachtung
12 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Bonito Peptides sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 1992–2020 mit einer typischen Studiengröße von 29 Teilnehmenden.
Basierend auf 12 Studien · 5 RCTs · 128 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Heart & blood pressureModerate Senkung des systolischen/diastolischen Blutdrucks (etwa 5-9 mmHg systolisch in kleinen japanischen Studien; deutlich geringer in Studien mit Brühe), konzentriert bei leichter/hochnormaler Hypertonie — nicht bei normotensiven Personen; die Studien sind klein, kurz und häufig industrienah. Kein Ersatz für blutdrucksenkende Medikamente. · 1-4 Wochen (Blutdruck), bei fortgesetzter Einnahme anhaltend
Überwiegend Mechanismus / Beobachtung11 Studien
Safety profile
Zu wenige bewertete Studien1 Studie
Ältere Forschungsbasis
Neueste Studie von 2020
199220062020
1RCTn=29 · very small study2000
Einfach gesagt: In the VY-group, reduction in systolic (S) and diastolic (D) BP was 9.7 and 5.3 mm Hg (P < 0. 001) at 1 week, and 9.3 and 5.2 mm Hg (P < 0.001) at 4 weeks, following the start of the E period, respectively.
Kawasaki T, Seki E, Osajima K, Yoshida M, Asada K, Matsui T, Osajima Y. · J Hum Hypertens (2000)
Randomized double-blind placebo-controlled trial in 29 mild-hypertensive volunteers
A 100-mL drink containing 3 mg of Val-Tyr (VY) was given twice daily for 4 weeks
SBP/DBP fell ~9.3/5.2 mmHg in the VY group with no change in placebo; BP rose again during recovery
Einfach gesagt: In group-H, both FDWG and FDW significantly decreased systolic (SBP, -7.6 +/- 4.0 and -5.5 +/- 1.5 mmHg, p<0.05, respectively) and diastolic (DBP, -10.6 +/- 4.0 and -7.6 +/- 1.7 mmHg, p<0.01, respectively) BP compared to the baseline (0-week) value at 12 weeks, respectively.
Tanaka H, Watanabe K, Ma M, Hirayama M, Kobayashi T, Oyama H, Sakaguchi Y, Kanda M, Kodama M, Aizawa Y. · J Clin Biochem Nutr (2009)
Double-blind, placebo-controlled, randomized study of a fermented drink containing vinegar and dried bonito (with or without GABA)
In hypertensive volunteers, SBP fell ~5.5-7.6 mmHg and DBP ~7.6-10.6 mmHg over 12 weeks
Both the GABA and non-GABA (dried-bonito) drinks lowered BP — the bonito component is implicated
Einfach gesagt: 40 subjects with mild hypertension or high-normal blood pressure (130 mmHg < or = systolic blood pressure (SBP) < 160 mmHg and/or 80 mmHg < or = diastolic blood pressure (DBP) < 100 mmHg) showed a significant decrease in SBP, from 142.0 +/- 10.3 mmHg at the start of the test to 134.4 +/- 11.1 mmHg during the first week of the test period, after which similar values were seen throughout the test period (13 weeks).
Kawasaki T, Jun CJ, Fukushima Y, Kegai K, Seki E, Osajima K, Itoh K, Matsui T, Matsumoto K. · Fukuoka Igaku Zasshi (2002)
Randomized double-blind placebo-controlled trial in 63 subjects (mild HTN, high-normal, and normal BP)
A vegetable drink with 0.5 g sardine peptides providing 0.4 mg Val-Tyr/day for 13 weeks
SBP fell ~7-8 mmHg and DBP significantly in the (pre)hypertensive subset versus control
5Tierstudie1999
Einfach gesagt: LKPNM (IC50 = 2.4 microM) was found to be hydrolyzed by ACE to produce LKP (IC50 = 0.32 microM) with 8-fold higher ACE-inhibitory activity relative to the parent peptide or LKPNM, suggesting that LKPNM can be regarded as a prodrug-type ACE-inhibitory peptide.
Fujita H, Yoshikawa M. · Immunopharmacology (1999)
Isolated LKPNM and seven other ACE-inhibitory peptides from the thermolysin digest of dried bonito (Katsuobushi)
LKPNM (IC50 2.4 µM) is cleaved by ACE to the ~8-fold more potent LKP (IC50 0.32 µM) — a prodrug mechanism giving prolonged effect
In SHR rats, LKPNM's antihypertensive activity was ~66% that of captopril on a molar basis (LKP ~91%)
Einfach gesagt: The change in systolic blood pressure during dried-bonito-broth ingestion was significantly lower than that during water ingestion (p = 0.037).
Umeki Y, Hayabuchi H, Hisano M, Kuroda M, Honda M, Ando B, Ohta M, Ikeda M. · J Clin Biochem Nutr (2008)
Randomized crossover human trial in 27 elderly Japanese subjects, 1 month per arm
Dried-bonito broth lowered systolic BP versus the water control and significantly reduced urinary 8-OHdG (oxidative-stress marker)
Emotional-state 'composure' also improved during broth ingestion
Einfach gesagt: LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8-fold by ACE itself and showed a prolonged effect after oral administration.
Yoshikawa M, Fujita H, Matoba N, Takenaka Y, Yamamoto T, Yamauchi R, Tsuruki H, Takahata K. · Biofactors (2000)
Review of food-protein-derived ACE-inhibitory and other bioactive peptides
Highlights bonito LKPNM as a prodrug-type ACE inhibitor with a prolonged oral effect
Places bonito peptides in the broader food-peptide / lifestyle-disease context (alongside ovokinin, milk peptides)
Einfach gesagt: Among the digests, thermolysin digest showed the most potent inhibitory activity. Eight inhibitory peptides were isolated from the digest using HPLC.
Einfach gesagt: In a long-term feeding experiment, in which 3 week old SHR were fed a standard chow supplemented with the digest for 7 weeks, elevation of the systolic blood pressure was significantly suppressed by 15 mg/kg per day of the digest.
Einfach gesagt: Proteolytic digestion of dried bonito muscle with thermolysin produces a hydrolysate with strong angiotensin-converting enzyme (ACE) inhibitory activity and is the basis of a dietary supplement with antihypertensive activity.
Einfach gesagt: Treatment with some ACE inhibitory small peptides (VY, Ile-Trp [IW], and Ile-Val-Tyr [IVY]) had diverse effects on serum-stimulated VSMC proliferation that were independent of their ACE inhibitory activity, though only VY exerted a potent antiproliferative action.
Matsui T, Ueno T, Tanaka M, Oka H, Miyamoto T, Osajima K, Matsumoto K. · Hypertens Res (2005)
Cell-culture study of Val-Tyr on human vascular smooth-muscle-cell proliferation
VY inhibited serum- and angiotensin-II-stimulated proliferation, partly via L-type Ca2+ channel inhibition and independent of ACE inhibition
Suggests a vascular mechanism beyond simple ACE inhibition