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Cft4.0

Caffeine (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

10 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Caffeine (topical) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus mittelwertigen randomisierten Studien, veröffentlicht 2007–2026 mit einer typischen Studiengröße von 210 Teilnehmenden.

Basierend auf 10 Studien · 2 RCTs · 253 Teilnehmende insgesamt

Konfidenz

Geringe Konfidenz

Nach Outcome

Hair & nails
Überwiegend Mechanismus / Beobachtung4 Studien
Men's vitality
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie

Aktives Forschungsgebiet

5 Studien in den letzten 5 Jahren

200720162026

1Systematische Übersicht2026

We have provided an Oral Dermatoses Map which illustrates key oral conditions and their associated anatomical areas of involvement.

Klein PA, Aristizabal MA, Janovska M, Bruce AJ, Bodiford KJ, Rogers RS. · Journal of the American Academy of Dermatology (2026)

The oral mucosa falls within the purview of dermatology.
It is the responsibility of dermatologists, along with oral medicine specialists, to help bridge this practice gap.
The purpose of this Part II manuscript is to provide differential diagnoses for common oral mucosal conditions based on sites of involvement.

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2Systematische Übersichtn=43 · small study2025

Side effects were mostly limited to localized pain with good outcomes and low recurrence rates.

Anagu O, Salas J, Choe S, Birda A, Sharma A, Baker G, Mesinkovska N. · Italian journal of dermatology and venereology (2025)

In onychomycosis, MAL PDT achieved a 40.9% cure rate and MB PDT showed a 77.8-100% cure rate with no reports of recurrence.
Parasitic infections, such as leishmaniasis have also been successfully treated with both 5-ALA and MAL PDT.
Conclusions PDT is a promising treatment option for cutaneous infections, with growing evidence for its utility in treating cutaneous bacterial, viral, fungal, and parasitic infections, particularly those that fail standard treatments.

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3Systematische Übersicht2024

Furthermore, genetic analysis can aid in predicting the effectiveness of laser photocoagulation in this patient population.

Zheng XY, Wu DW, Yu L, Zhao ZY. · BMC pediatrics (2024)

A favorable outcome was observed during the 2-month follow-up period.
Conclusions The co-occurrence of ROP and OCA is a rare phenomenon, and this is the first recorded case in the Chinese population.
The current case supports the use of laser as the primary treatment modality for ROP in OCA2 patients with partial pigmentation impairment.

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4Systematische Übersicht2024

Key messages Besides topical tazarotene and vitamin D analogs for nail psoriasis treatment, there is limited evidence for treatment of nail disorders with topical, oral, and intralesional vitamin/vitamin derivatives.

Curtis KL, Lipner SR. · Skin appendage disorders (2024)

Forty-nine articles were reviewed.
There is good evidence to support the use of topical tazarotene and vitamin D analogs for nail psoriasis treatment.
Further research warranted to confirm findings

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5Systematische Übersicht2025

SWT, radiofrequency therapy, and subcutaneous injectables have shown promising findings in cellulite treatment.

Lim SK, Gultekin G, Suresan S, Jacob A, Zou Y, Liyanage DD, Parekh JN, Mavilakandy AK, Vyas K, Khajuria A · Aesthetic Plast Surg (2025)

PROSPERO-registered systematic review of 24 RCTs (2,084 patients) across mechanical, topical, shockwave, laser, radiofrequency, injectable, and ultrasound cellulite treatments
Shockwave therapy, radiofrequency, and injectables emerged as the standouts; topical therapy was NOT identified among the effective interventions
Counter-evidence: the most rigorous cellulite synthesis does not single out topical (caffeine-type) therapy as effective

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6RCTn=210 · medium study2017

At 6 months, the group of the 5% minoxidil solution showed a mean improvement in anagen ratio of the trichogram of 11.68%, and the group of the 0.2% caffeine solution had an anagen improvement of 10.59%.

Dhurat R, Chitallia J, May TW, Jayaraaman AM, Madhukara J, Anandan S, Vaidya P, Klenk A · Skin Pharmacol Physiol (2017)

Open-label noninferiority RCT (n=210) comparing 0.2% topical caffeine liquid vs 5% minoxidil solution over 6 months in male AGA
Caffeine raised the anagen-hair ratio 10.59% vs 11.68% for minoxidil (difference 1.09%), meeting noninferiority
Authors conclude caffeine should be considered not inferior to minoxidil 5% — but the design is open-label and industry-linked

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7RCT2020

Subjects using the phyto-caffeine-containing shampoo had significantly fewer hairs pulled in a hair pull test at 6 months, compared with subjects using the control shampoo (-3.1 vs. -0.5 hairs; P<0.001).

Bussoletti C, Tolaini MV, Celleno L · G Ital Dermatol Venereol (2020)

Single-center, double-blind parallel RCT in women with AGA: a phyto-caffeine shampoo vs control shampoo over 6 months
Caffeine shampoo significantly reduced hairs pulled in the hair-pull test (-3.1 vs -0.5; P<0.001) plus most secondary endpoints; both well tolerated
Caveat: a multi-ingredient 'phyto-caffeine' cosmetic (not caffeine alone), single-center; the abstract reports no numeric sample size (left null, not fabricated)

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8In vitro2007

Significant growth suppression was found in hair follicles treated with 5 microg/ml testosterone. This was counteracted by caffeine in concentrations of 0.001% and 0.005%.

Fischer TW, Hipler UC, Elsner P · Int J Dermatol (2007)

Hair organ-culture model using follicles from biopsies of male AGA patients' vertex scalp
Testosterone suppressed follicle growth; caffeine (0.001-0.005%) counteracted this and caffeine alone significantly stimulated growth (Ki-67 confirmed)
Establishes the androgen-antagonism mechanism for caffeine in AGA — but in-vitro only

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9In vitro2014

Caffeine enhanced hair shaft elongation, prolonged anagen duration and stimulated hair matrix keratinocyte proliferation.

Fischer TW, Herczeg-Lisztes E, Funk W, Zillikens D, Bíró T, Paus R · Br J Dermatol (2014)

Organ-cultured male and female human scalp follicles treated with testosterone +/- caffeine for 120 h
Caffeine prolonged anagen, boosted matrix keratinocyte proliferation, raised IGF-1, and counteracted testosterone-enhanced TGF-beta2; female follicles were more sensitive
Deepens the molecular mechanism but remains an ex-vivo/in-vitro model, not a clinical outcome

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10Übersicht2013

This alkaloid stimulates the degradation of fats during lipolysis through inhibition of the phosphodiesterase activity.

Herman A, Herman AP · Skin Pharmacol Physiol (2013)

Narrative review of caffeine's cosmetic mechanisms: skin penetration, anti-cellulite lipolysis via phosphodiesterase inhibition, antioxidant/photoprotection, microcirculation
States caffeine stimulates hair growth through 5-alpha-reductase inhibition and is used in anti-cellulite products at typically ~3%
Mechanism-level support only; a non-systematic review, not efficacy evidence

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In der Forschungsbibliothek ansehen

Caffeine (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

The dermatologic oral examination: Navigating the Oral Dermatoses Map

The emerging role of photodynamic therapy in the treatment of cutaneous infections

Successful treatment of retinopathy of prematurity in oculocutaneous albinism with OCA2 variants: a case report and review of literature

Vitamins for the Management of Nail Disease: A Literature Review

Comparative Analysis of Cellulite Treatment Modalities: A Systematic Review.

An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia.

Efficacy of a cosmetic phyto-caffeine shampoo in female androgenetic alopecia.

Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro.

Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro.

Caffeine's mechanisms of action and its cosmetic use.