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Cft4.0

Caffeine (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

8 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Caffeine (topical) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 1977–2025 mit einer typischen Studiengröße von 210 Teilnehmenden.

Basierend auf 8 Studien · 4 RCTs · 210 Teilnehmende insgesamt

Konfidenz

Mittlere Konfidenz

Nach Outcome

Hair & nails
Überwiegend Mechanismus / Beobachtung3 Studien
Men's vitality
Zu wenige bewertete Studien2 Studien
Skin health
Zu wenige bewertete Studien1 Studie

Stetige Forschung

1 Studie in den letzten 5 Jahren

197720012025

1RCT1977

Kaplan RJ, Daman L, Rosenberg EW, Feigenbaum S · Arch Dermatol (1977)

2RCT1995

Jegla T, Salkoff L · Recept Channels (1995)

3Systematische Übersicht2025

Einfach gesagt: SWT, radiofrequency therapy, and subcutaneous injectables have shown promising findings in cellulite treatment.

Lim SK, Gultekin G, Suresan S, Jacob A, Zou Y, Liyanage DD, Parekh JN, Mavilakandy AK, Vyas K, Khajuria A · Aesthetic Plast Surg (2025)

Shockwave therapy, radiofrequency, and injectables emerged as the standouts; topical therapy was NOT identified among the effective interventions
Counter-evidence: the most rigorous cellulite synthesis does not single out topical (caffeine-type) therapy as effective

Quelle ansehen

4RCTn=210 · medium study2017

Einfach gesagt: At 6 months, the group of the 5% minoxidil solution showed a mean improvement in anagen ratio of the trichogram of 11.68%, and the group of the 0.2% caffeine solution had an anagen improvement of 10.59%.

Dhurat R, Chitallia J, May TW, Jayaraaman AM, Madhukara J, Anandan S, Vaidya P, Klenk A · Skin Pharmacol Physiol (2017)

Open-label noninferiority RCT (n=210) comparing 0.2% topical caffeine liquid vs 5% minoxidil solution over 6 months in male AGA
Caffeine raised the anagen-hair ratio 10.59% vs 11.68% for minoxidil (difference 1.09%), meeting noninferiority
Authors conclude caffeine should be considered not inferior to minoxidil 5% — but the design is open-label and industry-linked

Quelle ansehen

5Übersicht2013

Einfach gesagt: This alkaloid stimulates the degradation of fats during lipolysis through inhibition of the phosphodiesterase activity.

Herman A, Herman AP · Skin Pharmacol Physiol (2013)

Narrative review of caffeine's cosmetic mechanisms: skin penetration, anti-cellulite lipolysis via phosphodiesterase inhibition, antioxidant/photoprotection, microcirculation
States caffeine stimulates hair growth through 5-alpha-reductase inhibition and is used in anti-cellulite products at typically ~3%
Mechanism-level support only; a non-systematic review, not efficacy evidence

Quelle ansehen

6In vitro2014

Einfach gesagt: Caffeine enhanced hair shaft elongation, prolonged anagen duration and stimulated hair matrix keratinocyte proliferation.

Fischer TW, Herczeg-Lisztes E, Funk W, Zillikens D, Bíró T, Paus R · Br J Dermatol (2014)

Organ-cultured male and female human scalp follicles treated with testosterone +/- caffeine for 120 h
Caffeine prolonged anagen, boosted matrix keratinocyte proliferation, raised IGF-1, and counteracted testosterone-enhanced TGF-beta2; female follicles were more sensitive
Deepens the molecular mechanism but remains an ex-vivo/in-vitro model, not a clinical outcome

Quelle ansehen

7In vitro2007

Einfach gesagt: Significant growth suppression was found in hair follicles treated with 5 microg/ml testosterone. This was counteracted by caffeine in concentrations of 0.001% and 0.005%.

Fischer TW, Hipler UC, Elsner P · Int J Dermatol (2007)

Hair organ-culture model using follicles from biopsies of male AGA patients' vertex scalp
Testosterone suppressed follicle growth; caffeine (0.001-0.005%) counteracted this and caffeine alone significantly stimulated growth (Ki-67 confirmed)
Establishes the androgen-antagonism mechanism for caffeine in AGA — but in-vitro only

Quelle ansehen

8RCT2020

Einfach gesagt: Subjects using the phyto-caffeine-containing shampoo had significantly fewer hairs pulled in a hair pull test at 6 months, compared with subjects using the control shampoo (-3.1 vs. -0.5 hairs; P<0.001).

Bussoletti C, Tolaini MV, Celleno L · G Ital Dermatol Venereol (2020)

Single-center, double-blind parallel RCT in women with AGA: a phyto-caffeine shampoo vs control shampoo over 6 months
Caffeine shampoo significantly reduced hairs pulled in the hair-pull test (-3.1 vs -0.5; P<0.001) plus most secondary endpoints; both well tolerated
Caveat: a multi-ingredient 'phyto-caffeine' cosmetic (not caffeine alone), single-center; the abstract reports no numeric sample size (left null, not fabricated)

Quelle ansehen

In der Forschungsbibliothek ansehen

Caffeine (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

Treatment of atopic dermatitis with topically applied caffeine--a follow-up report.

A multigene family of novel K+ channels from Paramecium tetraurelia.

Comparative Analysis of Cellulite Treatment Modalities: A Systematic Review.

An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia.

Caffeine's mechanisms of action and its cosmetic use.

Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro.

Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro.

Efficacy of a cosmetic phyto-caffeine shampoo in female androgenetic alopecia.