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Ce5.0
Ceramides – Forschung
Überwiegend Mechanismus / Beobachtung
26 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Ceramides sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2011–2026 mit einer typischen Studiengröße von 60 Teilnehmenden.
Basierend auf 26 Studien · 1 Meta-Analyse · 6 RCTs · 1,051 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen· 24 weitere ohne bewertete Effektdaten
Nach Outcome
Skin healthKleine RCTs zeigen eine verbesserte Hautfeuchtigkeit; erste Signale für Faltenreduktion/Elastizität · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung9 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung8 Studien
Depression & mood
Überwiegend Mechanismus / Beobachtung7 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Inflammation
Zu wenige bewertete Studien1 Studie
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 11 Studien mit messbaren Effekten gezogen
Untersuchte Personen
1,051
typische Studie: 60 Personen
Stärkste Designs
7
1 gepoolt, 6 randomisiert
Zeigte Nutzen
100%
2/2 Studien
Wie lange Studien liefen
1–3 Monate
3
3+ Monate
1
Untersuchte Populationen
General population1
adults with dry skin1
Individuals with sphingolipid metabolism variations1
Systematic review (multiple populations)1
Aktives Forschungsgebiet
23 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2020
201120182026
1Systematische Übersichtn=623 · large study2026
Lipidomics, metabolomics, and microglia are likely to represent future research frontiers.
Xie MR, Chen YJ, Yuan H. · Frontiers in aging neuroscience (2026)
Conclusion Research on sphingolipids in AD exhibits an overall fluctuating upward trend.
Extensive collaboration among researchers from various institutions has facilitated advancements in this field.
Sphingolipid metabolism represents a key focus in AD research, with ceramides and sphingomyelins identified as critical molecules.
Targeting both immune pathways and epidermal lipid homeostasis may represent an effective strategy to restore barrier function and improve clinical outcomes.
Andrzejczak K et al. · Cells (2026)
IL-4/IL-13 signaling via the JAK-STAT pathway, particularly STAT6, contributes to keratinocyte dysfunction, resulting in impaired differentiation and coordinated alterations in lipid metabolism, including fatty acid elongation and ceramide synthesis.
These cytokine-driven processes disrupt the organization of the stratum corneum lipid matrix, resulting in increased transepidermal water loss, enhanced skin permeability, and susceptibility to microbial colonization, thereby promoting chronic inflammation.
Targeting both immune pathways and epidermal lipid homeostasis may represent an effective strategy to restore barrier function and improve clinical outcomes.
This narrative review aims to comprehensively elucidate the potential roles of ceramides in AD pathogenesis, exploring their associations with triggering inflammatory responses, mediating apoptosis, interfering with signal transduction, and inducing mitochondrial dysfunction.
Zhao W, Liu X, Yao Y, Yu Y, Hu Z. · Frontiers in neuroscience (2026)
The search was restricted to English-language literature.
Additionally, the reference lists of retrieved articles were manually screened to identify further relevant studies.
This narrative review aims to comprehensively elucidate the potential roles of ceramides in AD pathogenesis, exploring their associations with triggering inflammatory responses, mediating apoptosis, interfering with signal transduction, and inducing mitochondrial dysfunction.
This article will review recent advances in understanding these neurobiological processes regulated by estrogens and the associated molecular mechanism.
González-García I et al. · Reviews in endocrine & metabolic disorders (2026)
A putative membrane ER coupled to Gq (Gq-mER) has been proposed to mediate E2 actions on G protein-gated inwardly rectifying potassium GIRK, on the small conductance calcium-activated potassium (SK) currents, and on the ATP-sensitive potassium (KATP) currents in hypothalamic neurons.
Finally, a chloride ion channel (Clic1) was recently proposed to mediate E2-induced excitation of ERα-expressing neurons in the hypothalamus.
This article will review recent advances in understanding these neurobiological processes regulated by estrogens and the associated molecular mechanism.
This review summarizes current data on the structure, metabolism, and intra- and extracellular signaling pathways of S1P, its dual role under physiological conditions and in multiple sclerosis, and analyzes approaches to pharmacological modulation of S1P signaling pathways, highlighting the prospects of selective targeted therapy aimed at immunomodulation, neuroprotection, and stimulation of remyelination.
Ganin DA et al. · Biochemistry. Biokhimiia (2026)
Sphingosine-1-phosphate (S1P) is one of the most extensively studied bioactive signaling molecules of sphingolipid metabolism, which plays a pivotal role in regulating numerous processes in the central nervous system and immune system.
Conclusions Portable, cost-effective manual thermal pulsation demonstrated non-inferiority to automatic thermal pulsation for MGD during the 4-week follow-up period, with therapeutic efficacy associated with meibum micro-organism and lipid components.
Cheng X, Huang H, Fan Z, Wang H, Zheng X, Dong L, Li M, Zhang G, Mi S. · BMJ open ophthalmology (2026)
Results ΔMGS, ΔNIBUT, ΔSPEED, ΔMES and ΔCFS were not significantly different between manual and automatic thermal pulsation groups in 4 weeks (both p>0.05), indicating non-inferior efficacy of manual thermal pulsation.
No serious ocular or device-related adverse events were reported.
A more complex meibum microorganism diversity and 46 differentially expressed lipids (such as triglycerides, diglycerides, ceramides and oxidised species) were identified in those with a relatively weak therapeutic efficacy.
We also focus on a recently discovered class of atypical neurotoxic sphingolipids as intermediates in peripheral neuropathies.
Muñoz-Gil S, Spassieva SD. · The Journal of biological chemistry (2026)
They constitute about 20% of brain lipids.
The structural characteristics of sphingolipid precursors, the long-chain bases and ceramides, determine their and complex sphingolipids biophysical properties and function.
In the current review, we are focusing on the role of chain length, saturation, and hydroxylation of sphingolipid precursors in nervous system physiology and pathology.
In this review, we spotlight how specific lipid-NLRP3 interactions and lipid-driven post-translational modifications orchestrate inflammasome priming and activation across cellular membranes.
De Matteis MA et al. · Advances in biological regulation (2026)
Emerging evidence points to lipids as central integrators: they act as direct NLRP3 ligands, post-translational modifiers, and membrane scaffolds that choreograph inflammasome priming and assembly.
Palmitoylation dynamically tunes NLRP3 stability, localization, and activation thresholds, while cardiolipin and PI4P function as organelle-specific lipid cues that recruit and activate NLRP3 at mitochondria and Golgi/endosomal membranes.
NLRP3 also senses shifts in cholesterol, fatty acids, and ceramides, mechanistically linking lipid imbalance to cardiometabolic and inflammatory disease.
Standardized analytical protocols, validated clinical thresholds, and prospective interventional studies are needed before these markers can be used routinely for risk stratification or disease monitoring.
Khattib A et al. · Current opinion in lipidology (2026)
Recent lipidomics platforms like spatial lipidomics and single-cell lipidomics may add value in developing personalised medicine therapies.
Majumder D et al. · Xenobiotica; the fate of foreign compounds in biological systems (2026)
This review emphasises the significance of lipids in chronic metabolic diseases like cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, neurodegenerative disorders, cancer, and chronic kidney disease. 4.
The discovery of various biomarkers of disease conditions via lipidomics analysis includes lipids such as ceramides, oxidised phospholipids, acylcarnitines, and lysophospholipids, which have been implicated in causing inflammation, oxidative stress, mitochondrial dysfunction, and fibrosis. 5.
Omics integration can aid in obtaining new perspectives in understanding disease pathophysiology and help in identifying novel therapeutic targets including PCSK9 (Proprotein convertase subtilisin/kexin type 9), ANGPTL3 (Angiopoietin-like 3), and inflammatory lipids.
The findings also emphasize that hypothalamic ceramide metabolism is modulated by both nutritional and hormonal cues and suggest that targeting this pathway may offer new strategies for treating metabolic disorders.
Le Stunff H et al. · Reviews in endocrine & metabolic disorders (2026)
This review details the mechanisms of de novo ceramide synthesis and explores how dysregulation of this pathway in the hypothalamus contributes to obesity and type 2 diabetes.
Serine palmitoyl-transferase and specific ceramide synthase isoforms are shown to play roles in mediating neuronal responses to metabolic stress.
The findings also emphasize that hypothalamic ceramide metabolism is modulated by both nutritional and hormonal cues and suggest that targeting this pathway may offer new strategies for treating metabolic disorders.
15Emotional well-being and psychiatric disordersSystematische Übersicht2026
Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
Kalinichenko LS et al. · Journal of neurochemistry (2026)
Multiple studies show the contribution of SLs to normal brain functioning and corresponding beneficial behavioral phenotypes, such as stress resilience, cognitive performance, and social interactions, which determine emotional well-being.
On the other hand, an imbalance in SL metabolism affects normal functioning of cells and thus contributes to the development of several psychiatric disorders, such as depression, anxiety, cognitive decline, schizophrenia, and others.
SLs are suggested as a potentially new mechanism of the key behavioral manifestations of emotional well-being, which might be further investigated as new biomarkers of life quality as well as physical and mental resilience.
Understanding lipid-pathogen interactions not only deepens mechanistic insight into the pathophysiology of neuroinfection but also opens new perspectives for precision diagnostics and lipid-targeted interventions.
Kruszewska E et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2026)
Distinct lipid signatures - including phosphatidylcholines (PC), sphingomyelins (SM), ceramides (Cer), and lysophosphatidylcholines (LysoPC) - serve as potential biomarkers for disease differentiation, prognosis, and therapeutic monitoring.
Understanding lipid-pathogen interactions not only deepens mechanistic insight into the pathophysiology of neuroinfection but also opens new perspectives for precision diagnostics and lipid-targeted interventions.
This article reviews the relationships between ceramides and disease pathogenesis, with a focus on dietary intervention as a viable strategy for lowering the concentration of circulating ceramides.
Wang S et al. · Journal of lipid research (2025)
Mechanistic insights into these interventions are discussed.
This article reviews the relationships between ceramides and disease pathogenesis, with a focus on dietary intervention as a viable strategy for lowering the concentration of circulating ceramides.
18Metabolic health outcomesSystematische Übersicht2025
Nutritional strategies targeting ceramide metabolism represent a promising approach to improve metabolic health.
Arias-Marroquín AT et al. · Clinical nutrition ESPEN (2025)
Nutritional strategies targeting ceramide metabolism represent a promising approach to improve metabolic health.
Beyond their therapeutic potential, ceramides also emerge as dynamic lipidomic biomarkers capable of reflecting early metabolic changes and monitoring the efficacy of nutritional interventions.
While some evidence is promising, the reliability of these products, as well as their optimal dosage and frequency, remains uncertain.
Cespedes Zablah A et al. · Dermatitis : contact, atopic, occupational, drug (2024)
Oral ceramides, blackcurrant seed oil, and hempseed oil have yet to be thoroughly studied, but preliminary results are promising.
Among the studies, the supplementation doses and duration of treatment varied extensively.
The literature did not provide comparative analysis between the supplements, and data on the overall safety and tolerability of these supplements are limited.