Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Ch6.5
Chlorella – Forschung
Hilft wahrscheinlich
53 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Chlorella scheint in 5 von 6 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2007–2026 mit einer typischen Studiengröße von 40 Teilnehmenden.
Basierend auf 53 Studien · 7 Meta-Analysen · 28 RCTs · 6,962 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
5geholfen1unklar· 47 weitere ohne bewertete Effektdaten
Nach Outcome
InflammationVerstärkte Ausscheidung von Schwermetallen und Toxinen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung10 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung9 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung9 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung7 Studien
Glucose & metabolicModerate Verbesserungen bei Lipid- und Glukosemarkern · 8-12 Wochen
Energy & fatigueBessere Energie durch Nährstoffunterstützung · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Women's health
Überwiegend Mechanismus / Beobachtung4 Studien
Lean body mass & muscle growth
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Recovery
Zu wenige bewertete Studien1 Studie
Depression & mood
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 37 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
6,962
typische Studie: 40 Personen
Stärkste Designs
35
7 gepoolt, 28 randomisiert
Zeigte Nutzen
83%
5/6 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–4 Wochen
1
1–3 Monate
7
Untersuchte Populationen
Adults6
Patients with type 2 diabetes mellitus2
Adults with autoimmune skin diseases1
Fibromyalgia patients1
Aktives Forschungsgebiet
30 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200720162026
1Identification of immunostimulatory herbal supplementsSystematische Übersichtn=469 · medium study2025
We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
Weiner JD et al. · Lupus science & medicine (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
This article may serve as a reference to help clinicians counsel patients with autoimmune skin diseases on the risks associated with use of specific herbal supplements.
3Systematische ÜbersichtCited 14×n=916 · large study2021
Increasing intake of fruits and vegetables over prolonged periods might have positive effects on lung function in individuals with COPD.
Furulund E et al. · International journal of chronic obstructive pulmonary disease (2021)
Increasing intake of fruits and vegetables over prolonged periods might have positive effects on lung function in individuals with COPD.
Some nutritional interventions also observed effects on systemic inflammation, health-related quality of life, and physical function, although with some mixed results.
Many of the trials were underpowered, had high dropout rates, or had a high risk of bias.
4Cardiovascular risk factorsMeta-AnalyseCited 44×n=797 · large study2018
The results indicated that Chlorella supplementation improved levels of TC, LDL-C, SBP, DBP, and FBG but the changes in TG, HDL-C, and BMI were not satisfactory.
Fallah AA et al. · Clinical nutrition (Edinburgh, Scotland) (2018)
Subgroup analyses based on intervention duration and Chlorella doses revealed that administration of Chlorella for 8 weeks or higher and doses higher than 4 g/day significantly reduced TC, LDL-C, SBP, and DBP levels in the participants.
Moreover, Chlorella supplementation significantly reduced TC and LDL-C levels in unhealthy individuals, and also reduced SBP and DBP in hypertensive ones.
The results indicated that Chlorella supplementation improved levels of TC, LDL-C, SBP, DBP, and FBG but the changes in TG, HDL-C, and BMI were not satisfactory.
5Iron status improvementSystematische ÜbersichtCited 2×2025
A. platensis and C. vulgaris are safe and effective microalgal supplements that enhance iron status and antioxidant defense, presenting promising alternatives to conventional iron therapy.
Lacurezeanu A et al. · Molecular nutrition & food research (2025)
No significant adverse effects or organ toxicity were reported in any of the included studies.
A. platensis and C. vulgaris are safe and effective microalgal supplements that enhance iron status and antioxidant defense, presenting promising alternatives to conventional iron therapy.
However, longer-term human clinical trials are needed to validate these findings and determine optimal dosing strategies.
Overall, the findings of this meta-analysis indicate supplementation with algae may exert beneficial effects on anthropometric indices.
Kazeminejad S et al. · Nutrition reviews (2025)
Overall, the findings of this meta-analysis indicate supplementation with algae may exert beneficial effects on anthropometric indices.
However, due to between-studies heterogeneity and very low to low levels of GRADE for significant outcomes, the results should be interpreted with caution.
8Pain improvement in fibromyalgiaSystematische ÜbersichtCited 52×2020
Therefore, there is insufficient evidence to recommend any one particular nutritional intervention for the management of fibromyalgia and further research is needed.
Lowry E et al. · Nutrients (2020)
It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females.
Significant improvements in reported pain were observed for those following a vegan diet, as well as with the low fermentable oligo di-mono-saccharides and polyols (FODMAP) diets.
Supplementation with Chlorella green algae, coenzyme Q10, acetyl-l-carnitine or a combination of vitamin C and E significantly improved measures of pain.
Consequently, while the evidence suggests the possibility of functional effects, the strength of the evidence and its generalizability across populations remains limited.
Wang Z et al. · Nutrients (2026)
This review synthesizes current studies, which demonstrate that algae represent a potent, sustainable protein source capable of enhancing dietary quality and promoting health.
The integration of algae-based products into plant-forward diets has the potential to contribute to global nutritional security and long-term public health.
However, the available clinical evidence remains heterogeneous and is largely based on small, short-term intervention studies, with substantial variability in algae species, processing methods and dosages.
Further work integrating standardized analytical frameworks with mechanistic and clinical validation will be required to establish its role in human nutrition and functional food applications.
Rzeski W et al. · Nutrients (2026)
Observed biological effects are consistent with a model of metabolic permissiveness, in which CGF-associated fractions may support endogenous cellular functions rather than directly initiating signaling cascades.
Key translational challenges include the lack of compositional standardization, limited nucleotide speciation, variability in extraction protocols, and the absence of pharmacokinetic and controlled human studies using well-characterized CGF preparations.
Overall, CGF may be conceptualized as a candidate dietary bioactive with redox-centered and metabolically permissive properties.
11adiposity, metabolic dysfunction, and oxidative stressSystematische Übersichtn=717 · large study2026
Further high-quality, well-powered randomized trials in diverse populations are needed to confirm these effects.
Jafari A, Mardani H, Mahmoudinezhad M, Karimi MA, Musazadeh V, Sharifi M. · Food science & nutrition (2026)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Additionally, there were significant increases in catalase activity (WMD = 19.15 IU/g Hb, 95% CI: 0.44 to 37.85), and superoxide dismutase levels (WMD = 20.53 U/L, 95% CI: 15.03 to 26.02).
Chlorella supplementation may benefit anthropometric and cardiometabolic outcomes in adults with overweight or obesity.
However, the overall certainty of evidence was low to very low according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework, limiting confidence in these findings.
However, the available literature lacks studies simultaneously addressing both gut microbiota and brain health parameters limiting the understanding of the underlying physiological mechanisms.
Felip O, García I, Santocildes G, Torrella JR, Viscor G, Torres JL, Ramos-Romero S. · Nutrients (2026)
Nineteen studies (90%), predominantly preclinical, reported positive associations between Chlorella consumption, gut microbiota modulation, and physiological or neurobehavioral markers related to the gut-brain axis.
Most of the studies included were conducted in animal models, with only a limited number of human trials.
Conclusions : Chlorella consumption may modulate gut microbiota composition and function, potentially influencing brain-related processes.
Conclusions : Further randomised trials are needed to better assess the potential of these supplements as adjuvants for the control of cardiovascular risk factors.
Pinto-Leite M, Martins D, Ferreira AC, Silva C, Trindade F, Saraiva F, Vitorino R, Barros R, Lima PA, Leite-Moreira A, Ferreira JP, S Barros A, Miranda IM. · Nutrients (2025)
On the other hand, Spirulina intake led to a significant reduction in diastolic BP (-0.42, 95% CI: -0.81 to -0.02, p = 0.04) but did not significantly affect lipemia indexes, despite a trend toward a reduction in total cholesterol (-0.17, 95% CI: -0.39 to 0.06, p = 0.15).
This meta-analysis suggests Spirulina supplementation can be used as an adjuvant to control cardiometabolic risk factors, particularly for BP.
However, the magnitude of this effect is small and of uncertain clinical significance.
14Chlorella vulgaris applications as food substituteSystematische Übersicht2024
Although C. vulgaris shows great potential as a nutritious food ingredient, overcoming existing challenges and optimizing production methods would be crucial for its successful adoption and widespread use.
Wang CA, Onyeaka H, Miri T, Soltani F. · Journal of food science (2024)
Additionally, Chlorella can accumulate heavy metals from its environment, necessitating stringent quality control measures.
Future prospects involve improving Chlorella strains through genetic manipulation to enhance nutrient content, developing cost-effective culture systems, and exploring advanced processing techniques like pulsed electric fields for better digestibility.
Addressing sensory issues through flavor-masking strategies and employing environmental management practices will further support Chlorella's integration into the food industry.
16Overall health statusCrossoverCited 7×n=44 · small study2021
However, large-scale clinical studies are needed to confirm our statements.
Chiu HF et al. · Journal of food biochemistry (2021)
Thus, consumption of chlorella could significantly improve the overall health status by suppressing various oxidative stress markers and aging stress markers.
In agreement with our hypothesis, our results also showed that subjected supplemented with Chlorella water extract could significantly improve overall health status by suppressing various oxidative stress markers and aging stress markers.
Hence, Chlorella could be developed into a novel anti-aging agent.
The results suggest that a fully replicated dietary cholesterol challenge may be useful in assessing the effectiveness of dietary supplements in maintaining the serum lipid profiles of adults whose habitual diets are high in cholesterol.
Kim S et al. · Nutrition journal (2016)
The results suggest that a fully replicated dietary cholesterol challenge may be useful in assessing the effectiveness of dietary supplements in maintaining the serum lipid profiles of adults whose habitual diets are high in cholesterol.
18Blood lactate concentration during exerciseRCTCited 1×n=20 · very small study2024
A total of 2 days of 6 g/day chlorella supplementation appears to lower the blood lactate response and increase O2 pulse during both submaximal and maximal intensity exercise but did not lead to any improvements in V˙O2max.
White H et al. · Nutrients (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Borderline
Exercise testing consisted of a 20 min submaximal cycle at 40% of their work rate max (WRmax) (watts), followed by an incremental V˙O2max test.
Following chlorella supplementation, blood lactate levels were significantly lower (p < 0.05) during submaximal exercise (3.05 ± 0.92 mmol/L vs. 2.67 ± 0.79 mmol/L) and following V˙O2max tests (12.79 ± 2.61 mmol/L vs. 11.56 ± 3.43 mmol/L).
No differences existed between conditions for oxygen consumption, RER, V˙O2max, or WRmax.
20Plasma amino acid responsesRCTCited 6×n=10 · very small study2024
The ingestion of a variety of novel non-animal-derived dietary protein sources elicits divergent plasma amino acid responses, which are further modulated by age.
van der Heijden I et al. · The British journal of nutrition (2024)
Likely real
Protein ingestion increased plasma total and essential amino acid concentrations (P < 0·001), to differing degrees between sources (P < 0·001), and the increase was further modulated by age (P < 0·001).
Postprandial total and essential amino acid availabilities were highest for pea, spirulina and mycoprotein and lowest for chlorella (all P < 0·05), but no effect of age was observed (P > 0·05).
The ingestion of a variety of novel non-animal-derived dietary protein sources elicits divergent plasma amino acid responses, which are further modulated by age.