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Chl2.5
Chlorophyll – Forschung
Überwiegend Mechanismus / Beobachtung
15 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Chlorophyll sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 1983–2026 mit einer typischen Studiengröße von 10 Teilnehmenden.
Basierend auf 15 Studien · 8 RCTs · 20 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Skin healthKleine Pilot-/Fallstudien zu TOPISCHEM Kupfer-Chlorophyllin-Gel berichten über Verbesserungen bei Akne, Porengröße, Rötung und Lichtalterung — von geringer Qualität und nicht orales 'flüssiges Chlorophyll' · 3-8 Wochen (topisch, Pilotdaten)
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
Stetige Forschung
3 Studien in den letzten 5 Jahren
198320042026
1Systematische Übersicht2014
Ulbricht C, Bramwell R, Catapang M, Giese N, Isaac R, Le TD · J Diet Suppl (2014)
Einfach gesagt: While promising, these findings require further clinical validation to establish effective therapeutic applications.
Sartore G, Zagotto G, Ragazzi E. · Nutrients (2025)
Chlorophyllin, a stable semi-synthetic derivative, also shows potential in improving glucose and lipid metabolism.
Notably, pheophorbide a demonstrates insulin-mimetic activity by stimulating glucose uptake via glucose transporters, offering a novel therapeutic avenue.
Overall, the antioxidant, anti-inflammatory, and insulin-mimicking properties of chlorophyll derivatives suggest a multifaceted approach to diabetes management.
Einfach gesagt: The objective of this review is to highlight the value of phyllobilins by compiling current knowledge, with a particular emphasis on their bioactivity and potential impact on human health.
Serra MDR, Pérez-Gálvez A, Roca M. · Antioxidants (Basel, Switzerland) (2026)
This, together with their favorable bioavailability, has heightened the importance of elucidating their bioactive properties.
Numerous studies have demonstrated their antioxidant and anticancer activities in vitro, as well as their ability to target actin.
The anti-inflammatory effects of phyllobilins have also been demonstrated by evaluating their ability to inhibit the COX-2 pathway or attenuate the activation of the tryptophan-kynurenine pathway.
Dasgupta A, Sawant S, Chatterjee A, Gota V, Sahu A, Choudhari A, Bhattacharya K, Puranik A, Dev I, Moiyadi A, Shetty P, Singh V, Menon N, Epari S, Sahay A, Shah A, Bano N, Shaikh F, Jirage A, Gupta T. · Cancer medicine (2025)
Discussion Radionecrosis leads to significant morbidity and is usually treated with corticosteroids, which can lead to several side effects from both acute and long-term use.
Refractory radionecrosis requires treatment with bevacizumab or surgical resection.
Chlorophyllin is a cheap, safe, and readily available phytopharmaceutical drug, which is being investigated in the phase 2 study and, if proven effective, can be considered an alternative for treating radionecrosis.
Einfach gesagt: A review situating chlorophyllin among dietary factors that reduce aflatoxin genotoxicity by blocking carcinogen activation/absorption — useful mechanistic context, not new efficacy.
Gross-Steinmeyer K, Eaton DL · Toxicology (2012)
Reviews how dietary components, including chlorophyllin, modulate aflatoxin B1 biotransformation and genotoxicity
Supports the carcinogen-sequestration mechanism behind the chlorophyllin aflatoxin trial
Mechanistic/contextual review, not a clinical efficacy study
Einfach gesagt: A small uncontrolled 8-week pilot reported improvement in fine lines and solar lentigines with a topical chlorophyllin gel — again pilot-grade and not controlled.
Sigler ML, Stephens TJ · J Drugs Dermatol (2015)
Single-center open pilot in 10 women with mild-moderate photodamage
Topical liposomal sodium copper chlorophyllin (0.066%) twice daily for 8 weeks showed statistically significant improvement vs baseline on all efficacy parameters
Well tolerated, but no control group and only 10 completers
14Pilotstudien=10 · very small study2015
Einfach gesagt: A small, single-center, uncontrolled 3-week pilot reported that a topical chlorophyllin gel improved acne and pore appearance — promising but low-quality and not placebo-controlled.
Single-center open pilot in 10 subjects with mild-moderate acne and large pores
Topical 0.1% sodium copper chlorophyllin gel twice daily for 3 weeks showed statistically significant improvement on all clinical parameters vs baseline
No placebo/control arm; very small sample and short duration
15Fallstudie2015
Einfach gesagt: A case-study report described reduced facial redness with topical chlorophyllin gel — the weakest tier of clinical evidence.
Vasily DB · J Drugs Dermatol (2015)
Case studies (not a controlled trial) of topical liposomal copper chlorophyllin gel in subjects with facial redness and erythematotelangiectatic rosacea
Reported anti-redness benefit, attributed to antioxidant/anti-inflammatory/antibacterial activity seen in vitro
Anecdotal-level evidence; no quantitative controlled outcome