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Cur7.5
Curcumin – Forschung
Hilft wahrscheinlich
818 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Curcumin scheint in 12 von 14 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1980–2027 mit einer typischen Studiengröße von 166 Teilnehmenden.
Basierend auf 817 Studien · 169 Meta-Analysen · 436 RCTs · 44,223 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
12geholfen2unklar· 803 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Hilft wahrscheinlich185 Studien
InflammationSignifikante Reduktion von Entzündungsmarkern · 4-8 weeks
Women's healthUnterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 weeks · Kann zur Linderung von Menstruationsbeschwerden und PMS-Symptomen beitragen · 1-3 cycles
Überwiegend Mechanismus / Beobachtung35 Studien
Digestive healthVerringert Reizdarmsymptome und unterstützt die Darmbarrierefunktion · 4-8 weeks
511 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2027
198020032027
1Knee osteoarthritis pain and stiffnessMeta-Analysen=4,599 · very large study2025
Einfach gesagt: However, further large-scale, well-designed randomized controlled trials (RCTs) are needed to confirm these findings, particularly those that include more standardized dosages and formulations, as well as to evaluate their long-term efficacy.
Zhang Y et al. · Nutrients (2025)
Bayesian rankings indicated Boswellia had the highest probability of being most effective for pain and stiffness, with krill oil and curcumin showing potential for function improvement.
Conclusions: Nutritional supplements, particularly Boswellia, appear to be effective and well-tolerated for improving KOA symptoms and function.
These results suggest that certain supplements may be useful as part of non-pharmacological KOA management.
2Depressive disorder symptomsMeta-Analysen=17,437 · very large study2025
Einfach gesagt: This extensive systematic review and NMA of nutraceuticals for treating depressive disorders indicated a number of nutraceuticals that could offer benefits, either as adjuncts or monotherapies.
Cheng YC et al. · Psychological medicine (2025)
Adjunctive nutraceuticals consistently showed better efficacy than antidepressants (ADT) alone in outcomes including SMD, remission, and response.
This extensive systematic review and NMA of nutraceuticals for treating depressive disorders indicated a number of nutraceuticals that could offer benefits, either as adjuncts or monotherapies.
3Global cognitive outcomesMeta-Analysen=531 · large study2025
Einfach gesagt: Preclinical in vivo evidence suggests curcumin enhances cognitive function in AD models.
Yu L et al. · The journal of prevention of Alzheimer's disease (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
In preclinical in vivo murine studies (n = 25; total animals = 572), curcumin consistently improved both acquisition memory (SMD = -1.78, 95 % CI: -2.12 to -1.43) and retention memory (SMD = 2.36, 95 % CI: 1.72 to 3.00) in rodent models of AD.
Overall, curcumin showed no significant effect on global cognitive outcomes compared to placebo (SMD = 0.14, 95 % CI: -0.78 to 1.07).
Subgroup analyses revealed significant improvements in working memory (SMD = 1.01, 95 % CI: 0.15 to 1.87) and processing speed (SMD = 0.37, 95 % CI: 0.07 to 0.67).
4Non-alcoholic fatty liver disease parametersMeta-Analysen=2,173 · very large study2022
Einfach gesagt: Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
Einfach gesagt: Compared with placebo, supplementation with curcuminoids was associated with a significant reduction in circulating CRP levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004).
Sahebkar A · Phytotherapy research : PTR (2014)
Compared with placebo, supplementation with curcuminoids was associated with a significant reduction in circulating CRP levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004).
This significant effect was maintained in subgroups of trials that used bioavailability-improved preparations of curcuminoids and had supplementation duration of ≥4 weeks, but not in the subgroups without these characteristics.
Supplementation with curcuminoids may reduce circulating CRP levels.
Einfach gesagt: The study found that turmeric/curcumin has a beneficial effect on some obesity indicators, which could contribute to weight management in individuals with prediabetes and T2DM.
Moradi Baniasadi M et al. · Nutrition & diabetes (2025)
Random-effects meta-analysis was performed to evaluate the weighted mean difference (WMD) and 95% confidence interval (CI), with a p-value ≤ 0.05 indicating statistical significance.
The study found that turmeric/curcumin has a beneficial effect on some obesity indicators, which could contribute to weight management in individuals with prediabetes and T2DM.