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Dge6.0
Verdauungsenzyme – Forschung
Hilft wahrscheinlich
18 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Verdauungsenzyme scheint in 5 von 5 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 39 Teilnehmenden.
Basierend auf 18 Studien · 1 Meta-Analyse · 9 RCTs · 962 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Was die Studien gefunden haben
5geholfen· 13 weitere ohne bewertete Effektdaten
Nach Outcome
Pancreatic insufficiency & GI symptomsReduziertes Blähungsgefühl und verbesserte Nahrungsmittelverträglichkeit innerhalb von 1-2 Wochen · 1-2 Wochen
Hilft wahrscheinlich15 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Glucose & metabolic
Zu wenige bewertete Studien2 Studien
In Zahlen
Aus 13 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
962
typische Studie: 39 Personen
Stärkste Designs
10
1 gepoolt, 9 randomisiert
Zeigte Nutzen
100%
5/5 Studien
Wie lange Studien liefen
3+ Monate
2
Untersuchte Populationen
Patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery2
Chronic pancreatitis patients1
Children with ASD1
Functional dyspepsia patients1
Aktives Forschungsgebiet
7 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2017
200620162026
1Coefficient of fat absorptionMeta-AnalyseCited 140×n=511 · large study2017
PERT is indicated to correct EPI and malnutrition in CP and may be improved by higher doses, enteric coating, administration during food and acid suppression.
de la Iglesia-García D et al. · Gut (2017)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
PERT improved CFA compared with baseline (83.7±6.0 vs 63.1±15.0, p<0.00001; I2=89%) and placebo (83.2±5.5 vs 67.4±7.0, p=0.0001; I2=86%).
PERT is indicated to correct EPI and malnutrition in CP and may be improved by higher doses, enteric coating, administration during food and acid suppression.
Further studies are required to determine optimal regimens, the impact of health inequalities and long-term effects on nutrition.
2Systematische ÜbersichtCited 4×n=39 · small study2025
The results also found that the main interventions used were dietary interventions and nutraceuticals, including targeted supplements, vitamins and minerals, omega 3 s and prebiotics, probiotics and digestive enzymes.
Doherty M et al. · Journal of autism and developmental disorders (2025)
The results of this systematic review identified that for autistic people, vitamin and mineral supplements may only be of benefit if there is a deficiency.
The results also found that the main interventions used were dietary interventions and nutraceuticals, including targeted supplements, vitamins and minerals, omega 3 s and prebiotics, probiotics and digestive enzymes.
Therapeutic intervention, which may consist of supplementation of pancreatic enzymes and/or vitamins in aged individuals with proven exocrine pancreas insufficiency, could contribute to healthy ageing.
Löhr JM et al. · Journal of internal medicine (2018)
Five per cent of people older than 70 years and ten per cent older than 80 years have pancreatic exocrine insufficiency (PEI) with a faecal elastase-1 below 200 μg g-1 stool, and 5% have severe PEI with faecal elastase-1 below 100 μg g-1 stool.
Malnutrition consists of deficits of fat-soluble vitamins and is affecting both patients with PEI and the elderly.
Secondary consequences may include decreased bone mineral density and results from impaired absorption of fat-soluble vitamin D due to impaired pancreatic exocrine function.
The results showed an improvement in NDI-SF1, NDI-SF2-5, VAS, and PSQI scores in subjects treated with the multi-enzyme blend, indicating an improvement in quality of life and of sleep, and a decre...
Ullah H et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2023)
The results showed an improvement in NDI-SF1, NDI-SF2-5, VAS, and PSQI scores in subjects treated with the multi-enzyme blend, indicating an improvement in quality of life and of sleep, and a decreased severity of pain, following the supplementation with digestive enzymes, without side effects.
In conclusion, treatment with digestive enzymes was found to be effective in the reduction of functional dyspepsia symptoms and in the improvement of sleep quality, and is well-tolerated.
7Fat and protein absorptionRCTCited 19×n=36 · small study2016
Pancrelipase improved fat and protein absorption in patients with EPI due to chronic pancreatitis or pancreatectomy, with or without DM, and matched the safety profile previously reported.
Whitcomb DC et al. · Pancreas (2016)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Mean changes in nutrient absorption were greater with pancrelipase versus placebo in patients with DM (CFA, 36.0% vs 7.5%, P < 0.0001; CNA, 33.4% vs 3.7%, P = 0.0002) and without DM (CFA, 25.2% vs 12.3%, P = 0.0326; CNA, 39.1% vs 17.6%, P = 0.1187).
Diabetes mellitus was not significantly associated with outcomes for CFA (P = 0.0802) and CNA (P = 0.2934).
Pancrelipase improved fat and protein absorption in patients with EPI due to chronic pancreatitis or pancreatectomy, with or without DM, and matched the safety profile previously reported.
8Weight gain and stool frequencyRCTCited 84×n=51 · small study2011
Pancrelipase was well tolerated over 6 months and resulted in statistically significant weight gain and reduced stool frequency in patients with EPI due to CP or PS previously managed with standard PERT.
Gubergrits N et al. · Alimentary pharmacology & therapeutics (2011)
The mean age was 50.9 years, 70.6% of patients were male, 76.5% had CP and 23.5% had undergone PS.
TEAEs were reported by 22 patients (43.1%) overall.
Only four patients (7.8%) had TEAEs that were considered treatment related.
9Nonverbal intellectual ability improvementRCTCited 131×n=67 · small study2018
Parents reported that the vitamin/mineral supplements, essential fatty acids, and HGCSF diet were the most beneficial.
Adams JB et al. · Nutrients (2018)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
There was a significant improvement in nonverbal intellectual ability in the treatment group compared to the non-treatment group (+6.7 ± 11 IQ points vs. -0.6 ± 11 IQ points, p = 0.009) based on a blinded clinical assessment.
Based on semi-blinded assessment, the treatment group, compared to the non-treatment group, had significantly greater improvement in autism symptoms and developmental age.
The treatment group had significantly greater increases in EPA, DHA, carnitine, and vitamins A, B2, B5, B6, B12, folic acid, and Coenzyme Q10.
10nutritional status and pancreatic functionSystematische Übersicht2026
de Pretis N et al. · European journal of gastroenterology & hepatology (2026)
Not only pancreatic secretions but also the interaction between exocrine and endocrine pancreatic function have relevance on nutritional status, and there is increasing evidence that nutritional status impacts the prognosis of both inflammatory and pancreatic neoplastic diseases of the pancreas.
Signs of malnutrition need to be investigated and identified in patients with pancreatic diseases to optimize the medical management and, potentially, to improve the clinical outcome.
This is the first review to provide insights into the potential roles of exogenous digestive enzymes as prebiotics.
Yang Y, Kumrungsee T, Okazaki Y, Watanabe T, Inoue J, Iguchi T, Fukuda S, Kuroda M, Nishio K, Yamaguchi S, Kato N. · Nutrients (2025)
Consistent with the hypothesis, all 13 studies in this review reported significant improvements in animal gut microbiota composition with the dietary supplementation of proteases and lipases.
Additionally, the possible mechanisms of the prebiotic-like effects of the enzymes through increased nutrient digestion were discussed.
This review explores how exogenous proteases and lipases influence gut microbiota composition and overall health.
This review describes the role of these non-pancreatic digestive enzymes in supporting nutritional health.
Borowitz D. · Biomolecules (2025)
The major post-pancreatic intestinal carbohydrate-digesting enzymes are sucrase-isomaltase, maltase-glucoamylase and lactase-phlorizin hydrolase.
There are no post-pancreatic mucosal enzymes that act on dietary triglycerides; however, the complete digestion of phospholipids depends on several brush border phospholipases.
Intestinal processing is an important contributor to digestion of proteins, although mucosal proteases may serve as signaling proteins rather than as primary adjuncts to dietary protein digestion and absorption.
14Fat and nitrogen maldigestionRCTCited 149×n=25 · very small study2010
Pancrelipase delayed-release 12,000-lipase unit capsules were effective in treating fat and nitrogen maldigestion with a TEAE rate similar to that of placebo in patients with EPI due to CP or PS.
Whitcomb DC et al. · The American journal of gastroenterology (2010)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
In total, 25 patients (median age of 54 years, 76% male) received pancrelipase and 29 patients (median age of 50 years, 69% male) received placebo.
Th e mean ± s.d. change from baseline in CFA was significantly greater with pancrelipase vs. placebo: 31.9 ± 18.6 vs. 8.7 ± 12.4 % ( P < 0.0001) [corrected].
Treatment-emergent adverse events (TEAEs) were reported in five patients (20.0%) in the pancrelipase group and in six (20.7%) in the placebo group; the most common were gastrointestinal (GI) events and metabolism/nutrition disorders.
15Gas production reductionRCTn=8 · very small study2007
The administration of 1200 GalU of alpha-galactosidase induced a significant reduction of both breath hydrogen excretion and severity of flatulence.
Di Stefano M et al. · Digestive Diseases and Sciences (2007)
Alpha-galactosidase reduced gas production following a meal rich in fermentable carbohydrates and may be helpful in patients with gas-related symptoms.
A reduction in severity was apparent for all considered symptoms, but both 300 and 1200 GalU induced a significant reduction in the total symptom score.
Randomized double-blind placebo-controlled crossover in healthy volunteers given a bean-rich test meal
16Fat excretionRCTCited 33×n=18 · very small study2006
EC-high-buffered pancrelipase decreased fat excretion, symbolizing improved fat absorption, when compared with EC-nonbuffered pancreatic enzymes given at equivalent, reduced (approximately 50% of usual) lipase doses in nourished subjects with cystic fibrosis and mild pulmonary disease.
Brady MS et al. · Journal of the American Dietetic Association (2006)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Mean fat excretion decreased significantly in each subject during periods when given EC-high-buffered pancrelipase compared with periods when given EC-nonbuffered enzymes (fat excretion 18.2% vs 24.9% or fat absorption 81.8% vs 75.1%, respectively; P=0.01).
Thirteen of 18 subjects (72%) excreted less fat when receiving EC-high-buffered pancrelipase whereas 10 (56%) decreased fat excretion by more than 5%, and five subjects did not respond.
EC-high-buffered pancrelipase decreased fat excretion, symbolizing improved fat absorption, when compared with EC-nonbuffered pancreatic enzymes given at equivalent, reduced (approximately 50% of usual) lipase doses in nourished subjects with cystic fibrosis and mild pulmonary disease.
Digestive enzymes are able to break down proteins and carbohydrates and lipids, and their supplementation may play a role in the management of digestive disorders, from lactose intolerance to cystic fibrosis.
Ianiro G et al. · Current Drug Metabolism (2016)
Animal-derived enzymes represent an established standard of care, however the growing study of plant-based and microbe-derived enzymes offers great promise in the advancement of digestive enzyme therapy.
New frontiers of enzyme replacement are being evaluated also in the treatment of diseases not specifically related to enzyme deficiency.
Reviews use of pancreatic enzymes, lactase (β-galactosidase) and conjugated bile acids