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Epn2.5
Epitalon – Forschung
Überwiegend Mechanismus / Beobachtung
11 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Epitalon sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 2001–2025.
Basierend auf 11 Studien · 1 RCT
Konfidenz
Geringe Konfidenz
Nach Outcome
Longevity & agingBescheidene Lebensverlängerung bei Tieren über eine postulierte Telomerase-Aktivierung; die Daten zur Langlebigkeit beim Menschen sind von geringer Aussagekraft und beziehen sich überwiegend auf einen Zirbeldrüsen-Extrakt, bei einem theoretischen Krebsrisiko. · Nicht etabliert (Humandaten von geringer Qualität)
Überwiegend Mechanismus / Beobachtung7 Studien
Circadian rhythm & jet lag
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Lässt nach
Nur 1 Studie in den letzten 5 Jahren
200120132025
1Übersicht2025
It remains uncertain whether these are the sole mechanisms of action of this compound ... the quantity of physico-chemical and structural investigations of this peptide remains quite limited.
Animal study in senescence-accelerated mice (SAMP-1/SAMR-1), originating group
Subcutaneous epitalon (1 µg/mouse) and melatonin reportedly extended survival in the last 10% of senescence-prone mice and prevented estrous-cycle disturbances
Predominant tumor type (malignant lymphoma) frequency not significantly changed
4Tierstudie2001
[Epithalon] decelerated free radical processes, prolonged the mice life span with an accompanying drop in spontaneous tumour incidence.
Anisimov VN, Khavinson VKh, Zavarzina NIu, Zabezhinskiĭ MA, Zimina OA, Popovich IG. · Ross Fiziol Zh Im I M Sechenova (2001)
Animal study: female CBA mice given subcutaneous Epithalon from 6 months of age until death (originating group)
No change in body weight or food intake; slowed age-related loss of estrous function and lowered body temperature
Reported prolonged lifespan and reduced spontaneous tumor incidence
5In vitro2012
Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium.
Epithalamin ... and its active fragment, epitalon (Ala-Glu-Asp-Gly) ... have an antioxidant mechanism that is quite different from the action of melatonin.
Pineal peptides reportedly raised total antioxidant/antiradical activity and antioxidant enzymes (SOD, glutathione peroxidase) in serum, liver and brain
Proposed antioxidant contribution to the 'geroprotective' effect
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation.
Follow-up in-vitro study in human fetal pulmonary fibroblasts (same group)
Epithalon reportedly elongated telomeres in aging cells back toward early-passage length
Treated cells made ~10 extra passages, framed as 'overcoming the Hayflick limit'
9RCT2006
After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy.
12-year clinical study (indexed RCT) in elderly coronary patients with accelerated cardiovascular aging, by the originating group
Reported lower all-cause and cardiovascular mortality and improved exercise tolerance vs control
Used epithalamine (the pineal extract), not the pure Epitalon tetrapeptide
10Beobachtungsstudie2007
Peptide preparations of the pineal gland (Epithalamin ... and Epitalon ...) recover night release of endogenous melatonin and lead to the normalization of the hormone circadian rhythm in the blood plasma.
Homeostasis restoration was accompanied by ... decreased mortality rate during observation ... 1.6-1.8-fold in the Epithalamin-treated group ... as compared to the control.
Khavinson VKh, Morozov VG. · Neuro Endocrinol Lett (2003)
Long (6-8 year) clinical observation in 266 elderly subjects by the originating institutes
Reported reduced mortality and lower incidence of cardiovascular/respiratory disease with pineal (Epithalamin) and thymic (Thymalin) peptides
Studied the crude pineal extract Epithalamin, NOT the pure Ala-Glu-Asp-Gly peptide