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Els3.0

Wimpernseren (kosmetisch) – Forschung

Überwiegend Mechanismus / Beobachtung

6 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Wimpernseren (kosmetisch) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen Studien, veröffentlicht 2012–2026 mit einer typischen Studiengröße von 30 Teilnehmenden.

Basierend auf 6 Studien · 116 Teilnehmende insgesamt

Konfidenz

Geringe Konfidenz

Nach Outcome

Hair & nails
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Vision & eye health
Zu wenige bewertete Studien1 Studie

Aktives Forschungsgebiet

5 Studien in den letzten 5 Jahren

201220192026

1Beobachtungsstudien=79 · small study2026

About 30% of them contain a prostaglandin analogue. Six prostaglandin analogues were found, including bimatoprost and norbimatoprost.

Couteau C, Coiffard L. · Ann Pharm Fr (2026)

Qualitative survey of 79 marketed cosmetic eyelash-growth serums
~30% contained a prostaglandin analogue (bimatoprost, norbimatoprost, ethyl tafluprostamide, isopropyl cloprostenate)
Prostaglandin analogues are not regulated for use in cosmetics — a regulatory/safety problem (the key counter-evidence)

Quelle ansehen

2Übersicht2024

While non-prostaglandins ingredients show promising data, more studies are needed due to a lack of formal evidence in eyelash serum use.

Baiyasi M, St Claire K, Hengy M, Tur K, Fahs F, Potts G. · J Cosmet Dermatol (2024)

Review splitting serums into prostaglandin-analog and non-prostaglandin categories; only bimatoprost has robust efficacy/safety evidence
Non-prostaglandin ingredients (peptides, panthenol) are 'promising' but formally under-evidenced
US law requires no FDA efficacy or safety assessment before OTC cosmetic lash serums reach consumers

Quelle ansehen

3In vitro2025

The verified analytical method was applied to eyelash serums currently available in the market, and norbimatoprost was detected in one product.

Han KM, Woo IS, Kim YK, Shin EJ, Sung MK, Kim HS, Kim HK. · J Pharm Biomed Anal (2025)

HPLC method screening 11 prostaglandin F2α analogs, applied to marketed eyelash serums
Norbimatoprost was detected in one marketed product; bimatoprost/tafluprost are illegal to include in cosmetics
Confirms undeclared prostaglandin drugs reach consumers in products sold as cosmetics

Quelle ansehen

4In vitro2025

These compounds exhibit abnormal reactions such as causing eyelash growth... however, some cases have reported side effects such as pigmentation and dry eyes.

Kim YK, Woo IS, Park CG, Kim A, Choi JD, Son KH, Han KM. · J Chromatogr A (2025)

Glaucoma-drug prostaglandin analogs (bimatoprost, travoprost, tafluprost) are illicitly mixed into eyelash serums sold as cosmetics, which legally cannot contain drugs
Reported side effects of these undeclared analogs include skin/iris pigmentation and dry eyes
A validated LC-MS/MS method was developed to monitor illegal prostaglandin analogs — addressing a regulatory gap

Quelle ansehen

5Fallstudien=7 · very small study2012

Patients using Latisse for its cosmetic enhancement of eyelash length should be warned of this potentially disfiguring side effect, since the cosmetic and ophthalmic preparations are identical.

Sira M, Verity DH, Malhotra R. · Aesthet Surg J (2012)

Case series (n=7): periorbital hollowing from fat atrophy as a side effect of topical prostaglandin-analog (bimatoprost) exposure
These changes can be irreversible and disfiguring
Because covert cosmetic serums share the same prostaglandin-analog active, the same periorbital risk plausibly extends to them

Quelle ansehen

6Open-Labeln=30 · small study2024

At 12 weeks, significant increases were observed in lash length (+8.3%), number (+5%), width (+10.1%), volume (+14.1%), arc (+13.4%), and angle (+28.3%) compared to baseline.

Fernandez-Gonzalez P, Truchuelo-Díez MT, Gómez-Sánchez MJ. · J Cosmet Dermatol (2024)

Open-label trial (n=30) of a peptide/glycosaminoglycan (non-prostaglandin) cosmetic serum over 12 weeks
Modest increases in lash length (+8.3%) and volume (+14.1%) vs baseline, with no adverse effects and high satisfaction
Uncontrolled, open-label, manufacturer-run — effect sizes are not placebo-adjusted

Quelle ansehen

In der Forschungsbibliothek ansehen

Wimpernseren (kosmetisch) – Forschung

Überwiegend Mechanismus / Beobachtung

Prostaglandin analogues in cosmetic products formulated for eyelash lengthening.

Eyelash serums: A comprehensive review.

HPLC method for detecting prostaglandin F2α analogs in cosmetics: Optimization for chromatographic separation and sample preparation.

Green extraction of prostaglandin analogs in cosmetics using deep eutectic solvents and detection via LC-MS/MS.

Topical bimatoprost 0.03% and iatrogenic eyelid and orbital lipodystrophy.

Open clinical trial evaluating the efficacy of a novel eyelash growth enhancer with peptides and glycosaminoglycans.