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Fen6.0
Fenugreek – Forschung
Hilft wahrscheinlich
61 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Fenugreek scheint in 12 von 13 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2005–2026 mit einer typischen Studiengröße von 80 Teilnehmenden.
Basierend auf 61 Studien · 20 Meta-Analysen · 15 RCTs · 11,012 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
12geholfen1unklar· 48 weitere ohne bewertete Effektdaten
Nach Outcome
Glucose & metabolicReduzierte postprandiale Glukosespitzen · 4-8 weeks · Verbessert die postprandiale Glukoseantwort und Lipidmarker · 8-12 weeks
Hilft wahrscheinlich23 Studien
Women's healthKann helfen, Wechseljahrsbeschwerden wie Hitzewallungen und Stimmungsschwankungen zu bewältigen · 4-8 weeks · Unterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 weeks · Kann helfen, Menstruationsbeschwerden und PMS-Symptome zu reduzieren · 1-3 cycles
Hilft wahrscheinlich21 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung8 Studien
Men's vitalityHemmt Aromatase und 5-alpha-Reduktase zur Modulation des Testosterons · 4-8 weeks
2Fasting blood glucoseMeta-AnalyseCited 22×n=894 · large study2023
Given the wider availability and lower cost of fenugreek, rigorous double-blinded randomized controlled trials should be conducted with fenugreek to understand its true potential as a diabetes control herbal agent.
Shabil M et al. · Medicina (Kaunas, Lithuania) (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Could be chance
The mean difference with 95% confidence intervals (CI) was calculated to represent the analysis.
The results showed a reduction in fasting blood glucose levels (MD: 3.70, 95% CI of -27.02, 19.62; p = 0.76), postprandial blood glucose (MD: -10.61, 95% CI of -68.48, 47.26; p = 0.72), and HbA1c (MD: -0.88, 95% CI -1.49, -0.27; p = 0.00) with fenugreek consumption.
Fourteen trials, consisting of 894 participants, were included in the meta-analysis.
5Anabolic and performance effectsMeta-AnalyseCited 3×n=449 · medium study2023
Seven studies with 449 participants (378 male, 71 female) met the inclusion criteria.
Isenmann E et al. · International journal of sports medicine (2023)
Seven studies with 449 participants (378 male, 71 female) met the inclusion criteria.
The meta-analysis shows that chronic application of fenugreek has performance-enhancing and anabolic effects in male athletes, but no statements can be made for female athletes.Thieme.
6Testosterone concentrationsSystematische ÜbersichtCited 28×n=32 · small study2021
Overall, 9 out of 32 studies demonstrated statistically significant increases in testosterone concentrations.
Smith SJ et al. · Advances in nutrition (Bethesda, Md.) (2021)
Overall, 9 out of 32 studies demonstrated statistically significant increases in testosterone concentrations.
Conclusions are moderated by the paucity of research for many herbs, the variation in dosages and extracts used, small sample sizes, and the heterogeneity of study characteristics.
Also, further research is required before definitive conclusions on efficacy and safety can be made.
The evidence presented in the current systematic review indicates that flour-derived foods intake is related to improve cardiometabolic risk factors parameters.
de Souza LVM et al. · Critical reviews in food science and nutrition (2024)
Chia flour, green banana flour, soy flour, and fenugreek powder showed improvements in blood pressure measurements.
Brazil nut flour and chia flour reduced total cholesterol.
Further high-quality studies should be conducted to establish the clinical efficacy of herbal medicines.
Correia AGDS et al. · Phytotherapy research : PTR (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Could be chance
The mean difference (MD) and the standardized MD (SMD) were adopted, and subgroup analyses were performed according to patient's clinical condition.
Saffron supplementation reduced FBG (MD: -9.06 mg/dl; 95%CI: -16.25 to -1.86; I2 = 40%; p = 0.12) and HbA1c (MD: -0.19%; 95%CI: -0.23 to -0.14; I2 = 0%; p > 0.99).
Our results show that using saffron and fenugreek can reduce FBG, PPBG, and HbA1c; however, there are some shortcomings that require attention for these results.
9Weight reductionMeta-AnalyseCited 74×n=279 · medium study2020
High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome.
Payab M et al. · Phytotherapy research : PTR (2020)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI).
In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: -0.88, 95 % CI: [-1.13, -0.63]) and triglyceride ([SMD]: -1.67, 95 % CI: [-2.54, -0.79]), respectively.
In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite.
10Breast milk productionMeta-AnalyseCited 31×n=122 · medium study2018
The NMA using pairwise comparison demonstrated the effect of C. amboinicus and palm date in the stimulation of the breast milk production was comparable and superior to all comparators.
Khan TM et al. · Phytotherapy research : PTR (2018)
Spürbar Nutzen
← SchlechterKein EffektBesser →
League tables were generated using treatment effect, weighted mean difference (WMD; 95% confidence interval, CI) for all pairwise comparisons, where WMD > 0 favors the column-defining treatment.
The NMA results of 4 studies indicated that consumption of fenugreek significantly increased amount of the produced breast milk [11.11, CI 95% 6.77, 15.46] versus placebo.
The pairwise comparison revealed that fenugreek was effective as a galactagogue compared to placebo, control, and reference groups WMD 17.79 [CI 11.71, 23.88].
11Pain intensity in dysmenorrheaMeta-AnalyseCited 1×2024
The results showed that the effect of fenugreek on pain intensity in dysmenorrhea is highly uncertain.
Hassanzadeh R et al. · Current drug research reviews (2024)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
The results showed that the pain intensity caused by primary dysmenorrhea decreased with fenugreek compared to placebo (pooled result SMD: -2.21; 95% CI: -3.26 to -1.17; Z: 4.17; p <0.001).
There was no significant difference between fenugreek with mefenamic acid (SMD: 0.05; 95% CI: -0.57 to 0.67; Z: 0.17; p = 0.86) and fenugreek with Chandrasura churna (SMD: 0.06; 95% CI: -0.56 to 0.68; Z: 0.19; p = 0.85).
The results showed that the effect of fenugreek on pain intensity in dysmenorrhea is highly uncertain.
14Glycemic controlMeta-AnalyseCited 59×n=487 · medium study2011
The current evidence suggests that supplementation with Ipomoea batatas, Silybum marianum, and Trigonella foenum-graecum may improve glycemic control in type 2 diabetes.
Suksomboon N et al. · Journal of ethnopharmacology (2011)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Ipomoea batatas, Silybum marianum and Trigonella foenum-graecum significantly improved glycemic control, whereas Cinnamomum cassia did not.
The pooled mean differences in HbA(1c) were -0.30% (95% CI -0.04% to -0.57%; P = 0.02), -1.92% (95% CI -0.51% to -3.32%; P = 0.008), and -1.13% (95% CI -0.11% to -2.14%; P = 0.03), respectively, for Ipomoea batatas, Silybum marianum, and Trigonella foenum-graecum.
The corresponding values for FBG were -10.20mg/dL (95% CI -5.32 mg/dL to -15.08 mg/dL; P<0.0001) and -38.05 mg/dL (95% CI -9.54 mg/dL to -66.57 mg/dL; P = 0.009), respectively, for Ipomoea batatas and Silybum marianum.
16Breast milk volumeMeta-AnalyseCited 62×n=20 · very small study2020
Due to extremely limited, very low certainty evidence, we do not know whether galactagogues have any effect on proportion of mothers who continued breastfeeding at 3, 4 and 6 months.
Foong SC et al. · The Cochrane database of systematic reviews (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Only one study (metoclopramide) reported on the outcome of infant weight, finding little or no difference (mean difference (MD) 23.0 grams, 95% confidence interval (CI) -47.71 to 93.71; 1 study, 20 participants; low-certainty evidence).
Three studies (metoclopramide, domperidone, sulpiride) reported on milk volume, finding pharmacological galactagogues may increase milk volume (MD 63.82 mL, 95% CI 25.91 to 101.72; I² = 34%; 3 studies, 151 participants; low-certainty evidence).
Three studies (fennel, fenugreek, moringa, mixed botanical tea) reported infant weight but could not be meta-analysed due to substantial clinical and statistical heterogeneity (I2 = 60%, 275 participants, very low-certainty evidence).
Further high-quality studies are needed to firmly establish the clinical efficacy of the plant.
Heshmat-Ghahdarijani K et al. · Phytotherapy research : PTR (2020)
The pooled weighted mean difference (MD) and its 95% confidence interval (CI) were calculated and pooled using a random-effect model.
There were no significant differences in TC, TG, and LDL between pre- and post-fenugreek studies in the noncontrolled studies however, the result of combination of four studies without control group showed a significant increase in mean HDL (0.81 [0.33,1.29]; p-value = .001).
Well-designed and well-conducted clinical trials that address the above limitations are necessary to generate a body of evidence as a basis for recommendations regarding herbal galactogogues.
Mortel M et al. · Journal of human lactation : official journal of International Lactation Consultant Association (2013)
Five trials found an increase in breast milk production.
Several limitations exist that affect the validity of the trial results, including small sample size, insufficient randomization methods, poorly defined eligibility criteria, use of poly-herbal interventions, and variable breastfeeding practices among enrolled subjects.
Given the insufficiency of evidence from these trials, no recommendation is made for the use of herbs as galactogogues.