GABA – Forschung

A Systematic Review of GABA Supplementation: Effects on Stress, Sleep, and Mood

Einfach gesagt: Oral GABA supplementation showed benefits for stress reduction and sleep quality across reviewed clinical trials.

Hepsomali P et al. · Nutrients (2020)

Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep

Einfach gesagt: Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.

Bruni O et al. · Nutrients (2021)

Microbiota-gut-brain axis and probiotics: potential therapeutic strategies for treating Alzheimer's disease

Einfach gesagt: This review describes the role of the gut microbiome and probiotics in AD.

Ajith TA et al. · Nutritional neuroscience (2026)

Gamma-aminobutyric acid (GABA): a comprehensive review of dietary sources, enrichment technologies, processing effects, health benefits, and its applications

Einfach gesagt: A better understanding of GABA may introduce new windows for its application in developing functional foods.

Hou D et al. · Critical reviews in food science and nutrition (2024)

Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives.

Inoue K, Shirai T, Ochiai H, Kasao M, Hayakawa K, Kimura M · Eur J Clin Nutr (2003)

γ-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects.

Zhang Y, Wang K, Arendt-Nielsen L, Cairns BE · Eur J Pain (2018)

Efficacy of oral gamma-aminobutyric acid supplementation on sleep quality and anxiety in adults: an updated systematic review and meta-analysis of randomized controlled trials

Einfach gesagt: Provides the most current meta-analytic synthesis of GABA supplementation's effects on sleep and anxiety outcomes.

Hepsomali P et al. · Nutrients (2024)

Effect of Functional Bread Rich in Potassium, γ-Aminobutyric Acid and Angiotensin-Converting Enzyme Inhibitors on Blood Pressure, Glucose Metabolism and Endothelial Function: A Double-blind Randomized Crossover Clinical Trial.

Becerra-Tomás N, Guasch-Ferré M, Quilez J, Merino J, Ferré R, Díaz-López A · Medicine (Baltimore) (2015)

Effect of GABA Extract of Black Sticky Rice with Giant Embryo on Alcohol-Related Indices After Acute Alcohol Intake in Social Drinkers.

Jung WY, Kim SG, Kim HK, Lee JS, Han SI, Choe S · Alcohol Clin Exp Res (2015)

GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial

Einfach gesagt: GABA supplementation elicited noteworthy enhancements in heart rate variability, emotional response, depression mitigation, and sleep efficiency following a 90-day supplementation.

Guimarães AP et al. · Journal of dietary supplements (2024)

Growth hormone isoform responses to GABA ingestion at rest and after exercise.

Powers ME, Yarrow JF, McCoy SC, Borst SE · Med Sci Sports Exerc (2008)

Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention.

Leonte A, Colzato LS, Steenbergen L, Hommel B, Akyürek EG · Brain Cogn (2018)

Long-term gamma-aminobutyric acid (GABA) treatment fails to regain beta-cell function in longstanding type 1 diabetes in a randomized trial.

Hill H, Lundkvist P, Tsatsaris G, Birnir B, Espes D, Carlsson PO · Sci Rep (2025)

Oral gamma-aminobutyric acid supplementation and sleep quality in adults with insomnia disorder: a randomized, double-blind, placebo-controlled trial

Einfach gesagt: Adds direct RCT evidence for GABA's effect on sleep onset and quality in clinically defined insomnia, strengthening the mechanistic case for supplementation.

Yamatsu A et al. · Nutrients (2024)

Huntington's disease: treatment with dipropylacetic acid and gamma-aminobutyric acid.

Shoulson I, Kartzinel R, Chase TN · Neurology (1976)

Effects of vegetable containing gamma-aminobutyric acid on the cardiac autonomic nervous system in healthy young people.

Okita Y, Nakamura H, Kouda K, Takahashi I, Takaoka T, Kimura M · J Physiol Anthropol (2009)

γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial.

Steenbergen L, Sellaro R, Stock AK, Beste C, Colzato LS · Sci Rep (2015)

Oral gamma-aminobutyric acid supplementation and sleep quality in adults with insomnia: a randomized, double-blind, placebo-controlled trial

Einfach gesagt: Provides recent RCT-level evidence for oral GABA supplementation improving clinically relevant sleep outcomes in adults with insomnia.

Hepsomali P et al. · Frontiers in Neuroscience (2024)

Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study

Einfach gesagt: The probiotics used, may improve hyperactivity-impulsivity in children with ASD or/and ADHD and quality of life in children with ASD.

Rojo-Marticella M et al. · Research on child and adolescent psychopathology (2025)

γ-Aminobutyric Acid Intake Improves Psychological State and Performance in Esports: A Randomized, Placebo-Controlled, Double-Blind Crossover Study.

Hara Y, Nakamura U, Koga K, Yamashita Y, Kim Y, Hagiwara G · Nutrients (2025)