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Gld3.5
Goldenseal – Forschung
Überwiegend Mechanismus / Beobachtung
9 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Goldenseal sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen randomisierten Studien, veröffentlicht 2005–2025.
Basierend auf 9 Studien · 5 RCTs
Konfidenz
Mittlere Konfidenz
Nach Outcome
Glucose & metabolic
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
4 Studien in den letzten 5 Jahren
200520152025
1Übersicht2024
Einfach gesagt: By exploring these emerging mechanisms, we aim to broaden the scope of natural product-drug interaction research and encourage comprehensive studies to better elucidate complex mechanisms.
Oyanna VO, Clarke JD. · Drug metabolism reviews (2024)
Applying the Biopharmaceutics Drug Disposition Classification System (BDDCS) can serve as a framework for predicting and understanding these interactions.
This understanding is vital for healthcare professionals to effectively anticipate and manage potential natural product-drug interactions, ensuring optimal patient therapeutic outcomes.
By exploring these emerging mechanisms, we aim to broaden the scope of natural product-drug interaction research and encourage comprehensive studies to better elucidate complex mechanisms.
Approximately 9% of Europeans and white Americans are either poor CYP2D6 metabolizers or poor OCT1 transporters.
Common OCT1 alleles *3 to *6 showed uptake reduced by at least 65% and Oct1/2 knockout mice showed 3.2-fold higher AUCs in liver perfusion experiments.
Females who were poor CYP2D6 metabolizers had an 80% lower M1-to-berberine ratio.
Einfach gesagt: Comparisons of pre- and post-supplementation MDZ pharmacokinetic parameters revealed significant inhibition of CYP3A by goldenseal... These findings suggest that significant herb-drug interactions may result from the concomitant ingestion of goldenseal and CYP3A substrates.
Gurley BJ et al. · Clinical pharmacology and therapeutics (2008)
Goldenseal significantly inhibited CYP3A (midazolam probe) in 16 healthy volunteers
Significant herb-drug interaction potential with CYP3A substrates
Einfach gesagt: Botanical supplements containing goldenseal strongly inhibited CYP2D6 and CYP3A4/5 activity in vivo... serious adverse interactions may result from the concomitant ingestion of goldenseal supplements and drugs that are CYP2D6 and CYP3A4/5 substrates.
Gurley BJ et al. · Clinical pharmacology and therapeutics (2005)
Goldenseal strongly inhibited CYP2D6 and CYP3A4/5 (~40%) in vivo
Serious adverse interaction potential with CYP2D6/CYP3A4 substrates
Einfach gesagt: supplementation with these specific formulations of goldenseal or kava kava did not appear to affect digoxin pharmacokinetics, suggesting that these supplements are not potent modulators of P-gp in vivo
Gurley BJ et al. · Drug metabolism and disposition: the biological fate of chemicals (2007)
Goldenseal did NOT significantly alter digoxin (P-glycoprotein substrate) pharmacokinetics
Not a potent P-gp modulator in vivo (distinct from its CYP effects)
Einfach gesagt: The aggregate pharmacokinetic data indicated no clinically meaningful interaction... However, metformin AUC decreased by ~20%, 14%, and 0% after goldenseal coadministration at low, moderate, and high metformin doses, respectively
Nguyen JT et al. · Clinical and translational science (2025)
No clinically meaningful overall interaction (metformin AUC GMR within no-effect range)
Dose-dependent decrease in metformin exposure (~20% at low metformin doses)
Open-label crossover in adults with type 2 diabetes
Einfach gesagt: Investigators studied four different herbal medicines (St John's wort, garlic, goldenseal and milk thistle) and one vitamin (vitamin C). Significant interactions were observed with St John's wort, garlic and vitamin C.
Mills E et al. · International journal of STD & AIDS (2005)
Reviewed goldenseal among natural products studied for HIV-drug interactions
Significant interactions were seen with St John's wort, garlic and vitamin C (not goldenseal specifically)
Methodological limits noted; further research urged