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Egc4.0

Green Tea / EGCG (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

6 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Green Tea / EGCG (topical) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 2001–2024 mit einer typischen Studiengröße von 20 Teilnehmenden.

Basierend auf 6 Studien · 1 RCT · 20 Teilnehmende insgesamt

Konfidenz

Geringe Konfidenz

Nach Outcome

Skin healthModerate Reduktion von Akneläsionen/Sebum (Split-Face-RCT + kleine Pilotstudie); adjuvant (kosmetisch) · 6-12 Wochen · Antioxidative photoprotektive Unterstützung und Strahlkraft als Ergänzung zum Sonnenschutz (kosmetisch, kein gesundheitliches Ergebnis) · 4-12 Wochen · Mögliche Unterstützung gegen lichtbedingte Hautalterung über antioxidative/MMP-Hemmung; überwiegend präklinisch (kosmetisch) · 8-24 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Inflammation
Zu wenige bewertete Studien1 Studie

Stetige Forschung

1 Studie in den letzten 5 Jahren

200120122024

1RCT2013

EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated.

Yoon JY, Kwon HH, Min SU, Thiboutot DM, Suh DH · J Invest Dermatol (2013)

In sebocytes, EGCG reduced sebum via the AMPK-SREBP-1 pathway and reduced inflammation by suppressing NF-kB and AP-1
EGCG induced sebocyte apoptosis and decreased C. acnes viability, targeting multiple acne features
Topical EGCG significantly improved acne in an 8-week randomized split-face clinical trial and was well tolerated

Quelle ansehen

2Open-Label2001

Application of green tea extracts resulted in a dose-dependent inhibition of the erythema response evoked by UV radiation.

Elmets CA, Singh D, Tubesing K, Matsui M, Katiyar S, Mukhtar H · J Am Acad Dermatol (2001)

Topical green tea extracts produced dose-dependent inhibition of UV-induced erythema in human volunteers (EGCG and ECG most effective)
Treated skin showed fewer sunburn cells and protection of epidermal Langerhans cells on histology
Green tea extracts also reduced UV-induced DNA damage — supporting a photoprotective role

Quelle ansehen

3Open-Label2001

application of EGCG (mg/cm(2) skin) before a single UV exposure of 4x minimal erythema dose (MED) markedly decreases UV-induced production of hydrogen peroxide (68-90%, P < 0.025-0.005) and nitric oxide (30-100%, P < 0.025-0.005) in both epidermis and dermis

Katiyar SK, Afaq F, Perez A, Mukhtar H · Carcinogenesis (2001)

Topical EGCG applied to human skin before UV markedly decreased UV-induced hydrogen peroxide and nitric oxide in epidermis and dermis
EGCG inhibited UV-induced inflammatory leukocyte infiltration and reduced epidermal lipid peroxidation (41-84%)
EGCG pretreatment restored UV-depleted glutathione and protected glutathione peroxidase

Quelle ansehen

4In vitro2024

ATE markedly suppressed UV-induced IL-6, IL-8, MMP-1 and MMP-9 expressions.

Kanlayavattanakul M, Khongkow M, Klinngam W, Chaikul P, Lourith N, Chueamchaitrakun P · Sci Rep (2024)

EGCG-rich tea extract showed antioxidant activity in vitro and in cultured human dermal fibroblasts (stronger than ascorbic acid)
In a HaCaT/fibroblast coculture it suppressed UV-induced IL-6, IL-8, MMP-1 and MMP-9 expression
In an ex-vivo human skin model it lowered IL-6/MMP-1 and promoted hyaluronic acid and collagen — an anti-photoaging mechanism (preclinical)

Quelle ansehen

5Pilotstudien=20 · very small study2009

The mean total lesion count (TLC) decreased from 24 before the treatment to 10 after 6 weeks after treatment, a reduction of 58.33%.

Elsaie ML, Abdelhamid MF, Elsaaiee LT, Emam HM · J Drugs Dermatol (2009)

Twenty patients applied 2% green tea lotion twice daily for 6 weeks for mild-to-moderate acne
Mean total lesion count fell from 24 to 10 (58.33%; P<0.0001) and severity index from 2.05 to 1.25 (39.02%; P<0.0001)
Small and uncontrolled, but supports a topical acne benefit

6In vitro2017

lipid nanoparticles did not show protection from UV degradation for EGCG in this work.

Chen J, Wei N, Lopez-Garcia M, Ambrose D, Lee J, Annelin C, Peterson T · Eur J Pharm Biopharm (2017)

EGCG, resveratrol, and vitamin E were formulated into lipid nanoparticles for skin delivery
Unlike resveratrol and vitamin E, EGCG was NOT protected from UV-induced degradation by the lipid nanoparticles
Highlights EGCG's stability and delivery hurdles for topical use — the key counter-evidence

Quelle ansehen

In der Forschungsbibliothek ansehen

Green Tea / EGCG (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes.

Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.

Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.

Recent insights into catechins-rich Assam tea extract for photoaging and senescent ageing.

The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris.

Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications.