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Gua3.0
Guarana – Forschung
Überwiegend Mechanismus / Beobachtung
23 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Guarana sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 2,062 Teilnehmenden.
Basierend auf 23 Studien · 4 Meta-Analysen · 15 RCTs · 2,082 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Energy & fatigueZuverlässige koffeinbedingte Energie; eine Metaanalyse belegt speziell eine Verringerung der krebsbedingten Fatigue · 30-60 minutes
Überwiegend Mechanismus / Beobachtung8 Studien
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
13 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200620162026
1Meta-Analyse2024
Maselli-Schoueri JH, Aguiar Junior PN, Giglio AD · Rev Assoc Med Bras (1992) (2024)
17Systematische Übersichtn=2,062 · very large study2025
Wang L, Xu X, Guo M, Dong Y, Ding H, Hao S, Huo L, Song Y, Gu J, Yu Z. · Frontiers in pharmacology (2025)
Moreover, Withania somnifera was found to be the most promising option for reducing fatigue (99.9%), pain (100.0%), and nausea (98.6%).
Conclusion The network meta-analysis indicates that Withania somnifera was effective in enhancing quality of life and contributed to a reduction in therapeutic side effects in BC patients.
Our findings support the therapeutic potential of plant bioactive substances in breast cancer care; however, further clinical validation of their efficacy is warranted.
Einfach gesagt: Well-designed, multicenter trials are essential to determine whether phytotherapy can meaningfully contribute to CRF management.
Matsas S, Medeiros Araujo de Matos U, Molina Llata C, Del Giglio A. · Diseases (Basel, Switzerland) (2026)
Standardized mean differences (SMDs) were pooled using a DerSimonian-Laird random-effects model.
Overall, phytotherapy provided a modest improvement in CRF (SMD = 0.31; 95% CI, 0.08-0.53; p = 0.022), though heterogeneity was substantial (I 2 = 56.7%).
In subgroup analyses, only the group of "other formulations" demonstrated significant benefit; ginseng and guaraná did not demonstrate statistically significant effects.
Einfach gesagt: Excessive EDs consumption poses a real cardiotoxic risk, especially in vulnerable populations, underscoring the need for further human research and potential regulatory consideration.
Ghamlouch A, Di Fazio N, Racciatti M, Del Duca F, Treves B, De Angelis G, De Matteis A, Maiese A, Frati P. · Cardiovascular toxicology (2025)
Notably, similarities between EDs and cocaine emerged, including shared mechanisms involving ion channel blockade, sympathetic overactivation, vasoconstriction, and prothrombotic states.
Chronic use of either substance can result in structural heart damage and remodelling.
Although EDs and cocaine differ in legal status and potency, their overlapping cardiovascular effects warrant greater clinical awareness and public education.
Einfach gesagt: Conclusion Acute ingestion of guarana improves the capacity to perform intermittent exercise in soccer players but seems to be ineffective to improve lower limb power, sprint, and agility.
Estrázulas JA, Pereira Dos Santos F, Taborda Machado AJ, Legnani E, Bertuzzi R, Lima-Silva AE. · Journal of the American Nutrition Association (2024)
However, guarana ingestion increased the distance covered in the YYIR1, compared with placebo ingestion ( p = 0.01).
The battery of tests included a countermovement jump test, sprints of 10 and 20 m, an Illinois agility test, and a Yo-Yo Intermittent Recovery Test level 1 (YYIR1).
Results Guarana ingestion did not improve countermovement jump, sprints, or agility ( p > 0.05).