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Hp5.5
Hesperidin – Forschung
Hilft wahrscheinlich
81 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Hesperidin scheint in 7 von 7 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2008–2026 mit einer typischen Studiengröße von 84 Teilnehmenden.
Basierend auf 80 Studien · 12 Meta-Analysen · 33 RCTs · 12,571 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
7geholfen· 73 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureMögliche moderate Blutdrucksenkung (vor allem bei Typ-2-Diabetes); keine eindeutige Wirkung bei gesunden Personen · 4-8 Wochen
Cholesterol & lipidsMögliche moderate Blutdrucksenkung (vor allem bei Typ-2-Diabetes); keine eindeutige Wirkung bei gesunden Personen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung8 Studien
Weight management
Überwiegend Mechanismus / Beobachtung8 Studien
Endurance & exercise performance
Hilft wahrscheinlich5 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung5 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
In Zahlen
Aus 38 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
71%
über Studien hinweg
Untersuchte Personen
13k
typische Studie: 84 Personen
Stärkste Designs
45
12 gepoolt, 33 randomisiert
Zeigte Nutzen
100%
7/7 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–4 Wochen
1
1–3 Monate
5
3+ Monate
1
Untersuchte Populationen
NAFLD patients2
Diabetes patients2
Adults2
Rheumatoid arthritis patients1
Aktives Forschungsgebiet
55 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200820172026
1Rheumatoid arthritis disease activity and inflammationMeta-Analysen=3,852 · very large study2023
Einfach gesagt: Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Long Z et al. · Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
2Non-alcoholic fatty liver disease treatmentMeta-Analysen=2,173 · very large study2022
Einfach gesagt: Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
3Chronic venous insufficiency symptomsMeta-Analysen=1,582 · large study2020
Einfach gesagt: There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Martinez-Zapata MJ et al. · Cochrane Database of Systematic Reviews (2020)
Phlebotonics (the class including diosmin/hesperidin) probably reduce lower-leg oedema slightly vs placebo (RR 0.70) and reduce ankle circumference
Little or no difference in quality of life, and no clear effect on ulcer healing
Phlebotonics probably increase adverse events slightly vs placebo (RR 1.14), most often gastrointestinal
4Neuroprotective effects in Alzheimer's diseaseSystematische Übersicht2025
Einfach gesagt: Few clinical trials have indicated that dietary supplements rich in hesperidin can improve cerebral blood flow, cognition, and memory performance.
Han X et al. · European journal of medicinal chemistry (2025)
Few clinical trials have indicated that dietary supplements rich in hesperidin can improve cerebral blood flow, cognition, and memory performance.
The neuroprotective effect of hesperidin may be exerted via regulating different molecular pathways, including the RAGE/NF-κB, Akt/Nrf2, and AMPK/BDNF/CREB pathways.
However, further clinical trials are needed to confirm the neuroprotective effects of this natural flavonoid compound and to assess its safety.
Einfach gesagt: Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
Ranneh Y et al. · Nutrients (2024)
Most studies on silymarin showed a reduction in liver enzymes and lipid profile; however, no changes were observed in inflammatory cytokine levels.
The dietary supplementation of hesperidin and naringenin or green tea extract caused improvements in liver enzyme, lipid profile, and inflammatory cytokine, while genistein supplementation did not modulate blood lipid profile.
In conclusion, dietary supplementation of polyphenols could potentially prevent and ameliorate NAFLD.
11Salivary gland damage from oxidative stressSystematische Übersicht2023
Einfach gesagt: Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.
Ungureanu LB et al. · Medicina (Kaunas, Lithuania) (2023)
Results: Out of 1756 articles, 25 articles were selected with data on tissue homogenate used for biochemical analysis of oxidative and antioxidative markers, along with routine hematoxylin eosin (HE) and immunohistochemical analysis used for histopathological and immunohistochemical diagnosis.
Drugs (antineoplastic drugs, antibiotics, and analgesics), alcohol, heavy metals, and fluoride can cause oxidative stress, resulting in morphological changes in different tissues, including in salivary glands.
12Blood glucose controlMeta-Analysen=318 · medium study2020
Einfach gesagt: Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
Shams-Rad S et al. · British journal of clinical pharmacology (2020)
Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
13Platelet signaling and responsivenessSystematische Übersicht2022
Einfach gesagt: We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
Tamer F et al. · Thrombosis and haemostasis (2022)
We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
Lastly, we provide guidance on which compounds are of interest for further platelet-related research.Thieme.
Einfach gesagt: Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity.
Amiot MJ et al. · Obesity reviews : an official journal of the International Association for the Study of Obesity (2016)
Green tea, however, significantly reduced body mass index and waist circumference and improved lipid metabolism.
However, some trials pointed towards an improvement of endothelial function in patients supplemented with cocoa, anthocyanin-rich berries, hesperidin or resveratrol.
Therefore, diets rich in polyphenols, such as the Mediterranean diet, which promote the consumption of diverse polyphenol-rich products could be an effective nutritional strategy to improve the health of patients with MetS.
Einfach gesagt: Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
Nwadiugwu MC · Frontiers in public health (2020)
Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events.
Results: Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome.
Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p < 0.05) reduction in inflammatory activities.
16Diabetes and related complicationsSystematische Übersicht2020
Einfach gesagt: Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
Gandhi GR et al. · Nutrients (2020)
All articles identified were analyzed, and data were extracted using a standardized form.
These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications.
Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
17Systematische Übersichtn=24 · very small study2019
Einfach gesagt: We recommend future clinical trials for more insights.
Musa AE et al. · Medicina (Kaunas, Lithuania) (2019)
Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage.
The best radioprotection was obtained when hesperidin was administered before irradiation.
Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage.
18Anti-diabetic potentialSystematische Übersichtn=10 · very small study2023
Einfach gesagt: Therefore, citrus flavanones are the candidates having promising anti-diabetic potential but their effect needs to be verified through human studies.
Azhar S et al. · Current diabetes reviews (2023)
Therefore, citrus flavanones are the candidates having promising anti-diabetic potential but their effect needs to be verified through human studies.