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Hp5.5
Hesperidin – Forschung
Hilft wahrscheinlich
61 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Hesperidin scheint in 8 von 10 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2016–2026 mit einer typischen Studiengröße von 75 Teilnehmenden.
Basierend auf 61 Studien · 12 Meta-Analysen · 19 RCTs · 15,542 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
8geholfen1unklar1nicht geholfen· 51 weitere ohne bewertete Effektdaten
Heart & blood pressureMögliche moderate Blutdrucksenkung (vor allem bei Typ-2-Diabetes); keine eindeutige Wirkung bei gesunden Personen · 4-8 Wochen
Gemischte Evidenz11 Studien
Cholesterol & lipidsMögliche moderate Blutdrucksenkung (vor allem bei Typ-2-Diabetes); keine eindeutige Wirkung bei gesunden Personen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung7 Studien
Weight management
Überwiegend Mechanismus / Beobachtung6 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung5 Studien
Endurance & exercise performance
Hilft wahrscheinlich4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
In Zahlen
Aus 44 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
16k
typische Studie: 75 Personen
Stärkste Designs
31
12 gepoolt, 19 randomisiert
Zeigte Nutzen
80%
8/10 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–4 Wochen
1
1–3 Monate
6
3+ Monate
1
Untersuchte Populationen
Adults4
Human adults2
Diabetes patients2
Amateur cyclists2
Aktives Forschungsgebiet
47 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
201620212026
1Non-alcoholic fatty liver disease parametersMeta-AnalyseCited 64×n=2,173 · very large study2022
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
2Systolic blood pressure reductionMeta-AnalyseCited 7×n=656 · large study2024
The results in patients with type 2 diabetes needed to be further supported by future research focusing on individuals with diabetes.
Gao H et al. · Phytotherapy research : PTR (2024)
The results of total population blood pressure showed that hesperidin had no antihypertensive effect on the population, but the conclusions changed when the population was divided into groups.
The results in patients with type 2 diabetes needed to be further supported by future research focusing on individuals with diabetes.
3Adverse eventsMeta-AnalyseCited 47×n=7,690 · very large study2020
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Martinez-Zapata MJ et al. · The Cochrane database of systematic reviews (2020)
Spürbar Schaden
← SchlechterKein EffektBesser →
Pooled data suggest that phlebotonics probably increase adverse events slightly, compared to placebo (RR 1.14, 95% CI 1.02 to 1.27; 37 studies; 5789 participants; moderate-certainty evidence).
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Moderate-certainty evidence suggests that phlebotonics are probably associated with a higher risk of adverse events than placebo.
4Anthropometric measuresMeta-AnalyseCited 3×n=512 · large study2021
The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures.
Djafari F et al. · Clinical nutrition ESPEN (2021)
The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures.
5Blood pressure and lipid profileMeta-AnalyseCited 38×n=577 · large study2019
Future well-designed trials are still needed to confirm these results.
Mohammadi M et al. · Phytotherapy research : PTR (2019)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Effect sizes were pooled by using the random effects model.
Hesperidin supplement also had no effect on systolic (WMD = -0.85 mmHg; 95% CI [-3.07, 1.36]) and diastolic blood pressure (WMD = -0.48 mmHg; 95% CI [-2.39, 1.42]).
Hesperidin supplementation might not improve lipid profile and blood pressure.
6Neuroprotective effects in Alzheimer's diseaseSystematische ÜbersichtCited 13×2025
Few clinical trials have indicated that dietary supplements rich in hesperidin can improve cerebral blood flow, cognition, and memory performance.
Han X et al. · European journal of medicinal chemistry (2025)
Few clinical trials have indicated that dietary supplements rich in hesperidin can improve cerebral blood flow, cognition, and memory performance.
The neuroprotective effect of hesperidin may be exerted via regulating different molecular pathways, including the RAGE/NF-κB, Akt/Nrf2, and AMPK/BDNF/CREB pathways.
However, further clinical trials are needed to confirm the neuroprotective effects of this natural flavonoid compound and to assess its safety.
Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
Ranneh Y et al. · Nutrients (2024)
Most studies on silymarin showed a reduction in liver enzymes and lipid profile; however, no changes were observed in inflammatory cytokine levels.
The dietary supplementation of hesperidin and naringenin or green tea extract caused improvements in liver enzyme, lipid profile, and inflammatory cytokine, while genistein supplementation did not modulate blood lipid profile.
In conclusion, dietary supplementation of polyphenols could potentially prevent and ameliorate NAFLD.
8Salivary gland damage from oxidative stressSystematische ÜbersichtCited 15×2023
Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.
Ungureanu LB et al. · Medicina (Kaunas, Lithuania) (2023)
Results: Out of 1756 articles, 25 articles were selected with data on tissue homogenate used for biochemical analysis of oxidative and antioxidative markers, along with routine hematoxylin eosin (HE) and immunohistochemical analysis used for histopathological and immunohistochemical diagnosis.
Drugs (antineoplastic drugs, antibiotics, and analgesics), alcohol, heavy metals, and fluoride can cause oxidative stress, resulting in morphological changes in different tissues, including in salivary glands.
9Anti-inflammatory and antioxidant responseMeta-AnalyseCited 37×2023
As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.
Buzdağlı Y et al. · International journal of environmental health research (2023)
Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies.
For the meta-analysis, eighteen studies were chosen.
Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels.
10Blood glucose controlMeta-AnalyseCited 19×n=318 · medium study2020
Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
Shams-Rad S et al. · British journal of clinical pharmacology (2020)
Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
11Inflammatory markersMeta-AnalyseCited 29×n=296 · medium study2019
The present study suggests that although hesperidin supplementation significantly improves VCAM-1 levels; however, other inflammatory markers might not be affected.
Lorzadeh E et al. · Chemico-biological interactions (2019)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The meta-analysis revealed that hesperidin significantly reduces Vascular Cell Adhesion Molecule 1 (VCAM-1) levels [weighted mean difference (WMD) = -22.81 ng/L, P = 0.041, n = 3].
The present study suggests that although hesperidin supplementation significantly improves VCAM-1 levels; however, other inflammatory markers might not be affected.
Further high-quality systematic reviews exploring the effect of hesperidin particularly on VCAM-1, ICAM-1, E-selectin, and interleukin 6 are still needed to confirm these results.
We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
Tamer F et al. · Thrombosis and haemostasis (2022)
We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
Lastly, we provide guidance on which compounds are of interest for further platelet-related research.Thieme.
Steps can be taken in future research to improve the consistency of clinical study designs, methodology and outcomes.
Tadros FJ et al. · Critical reviews in food science and nutrition (2022)
This narrative systematic review aimed to determine appropriate recommendations toward the dose and frequency of hesperidin consumption from 100% orange juice and conduct a gap analysis.
Results showed that overall effect sizes from the studies were considerably weak.
Although higher frequencies, doses, and concentration of hesperidin in 100% orange juice had an impact on global cognitive function, cardiac, insulin, inflammatory, antioxidant/phenolic, and oxidative stress outcomes compared to lower frequencies, doses, and concentration of hesperidin.
14Inflammatory activities in type 2 diabetes with angiopathiesSystematische ÜbersichtCited 18×2020
Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
Nwadiugwu MC · Frontiers in public health (2020)
Borderline
Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events.
Results: Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome.
Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p < 0.05) reduction in inflammatory activities.
15Diabetes and related complicationsSystematische ÜbersichtCited 172×2020
Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
Gandhi GR et al. · Nutrients (2020)
All articles identified were analyzed, and data were extracted using a standardized form.
These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications.
Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
17Systematische ÜbersichtCited 22×n=24 · very small study2019
We recommend future clinical trials for more insights.
Musa AE et al. · Medicina (Kaunas, Lithuania) (2019)
Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage.
The best radioprotection was obtained when hesperidin was administered before irradiation.
Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage.
Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity.
Amiot MJ et al. · Obesity reviews : an official journal of the International Association for the Study of Obesity (2016)
Green tea, however, significantly reduced body mass index and waist circumference and improved lipid metabolism.
However, some trials pointed towards an improvement of endothelial function in patients supplemented with cocoa, anthocyanin-rich berries, hesperidin or resveratrol.
Therefore, diets rich in polyphenols, such as the Mediterranean diet, which promote the consumption of diverse polyphenol-rich products could be an effective nutritional strategy to improve the health of patients with MetS.
20Gastrointestinal and cardiometabolic health outcomesÜbersichtn=84 · small study2026
Future research should prioritize well-designed clinical trials and investigate potential synergistic interactions among OP-derived bioactive fractions to support their translational application.
Vilas-Boas AA et al. · Nutrients (2026)
Conclusions: Upcycled OP ingredients show promising biological activities relevant to cardiometabolic health and gut modulation, particularly in mechanistic and preclinical models.
However, the evidence base remains largely dominated by in vitro and animal studies, with limited and heterogeneous clinical data.
Key gaps include the underrepresentation of pectin and carotenoids in human trials and the absence of standardized, long-term intervention studies.