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HIB6.0
Hibiscus – Forschung
Überwiegend Mechanismus / Beobachtung
33 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Hibiscus sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2004–2025 mit einer typischen Studiengröße von 54 Teilnehmenden.
Basierend auf 33 Studien · 8 Meta-Analysen · 16 RCTs · 1,116 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Heart & blood pressureModerate systolische Blutdrucksenkung (~5-7 mmHg) bei Prä-/leichter Hypertonie; nicht gleichwertig mit blutdrucksenkenden Medikamenten · 4–6 Wochen
15 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200420142025
1Systematische Übersichtn=25 · very small study2025
However, the results did not demonstrate benefits in a study focused on wound healing, indicating that further studies are needed to investigate its specific application.
Nogueira da Cruz ACS, Madruga Mesquita MJTA, Dantas GKR, Silva ER, Falcone De Oliveira VC, Rezende HM, Frota GM, Cavalcante M, Garcês JRC, Souza de Andrade M, Cartagenes MDSS. · Food science & nutrition (2025)
No articles were found in the LILACS database, indicating that the search did not return relevant results within the search criteria.
One article was found in the VHL database, but it was excluded due to duplication with an article already found in the PUBMED database.
However, the results did not demonstrate benefits in a study focused on wound healing, indicating that further studies are needed to investigate its specific application.
Hibiscus sabdariffa supplementation significantly reduced systolic and diastolic blood pressure and had favorable effects on lipid and glycemic parameters in cardiometabolic health.
Norouzzadeh M et al. · Complementary therapies in medicine (2025)
Overview of systematic reviews and updated dose-response meta-analysis confirms cardiometabolic benefits of Hibiscus sabdariffa
Significant reductions in systolic and diastolic blood pressure across pooled analyses
Favorable effects on LDL cholesterol and fasting blood glucose documented
Hibiscus exerted stronger effects on systolic BP (-7.10 mmHg) than placebo, with the magnitude of reduction greatest in those with elevated BP at baseline.
Ellis LR et al. · Nutrition reviews (2022)
Hibiscus significantly reduced systolic BP by −7.10 mmHg (95%CI −13.00 to −1.20) versus placebo
Our study did not show a clinical benefit of H. sabdariffa extract in obesity treatment; mean difference in weight reduction was −0.27 kg (95%CI −1.98 to 1.42).
Dilokthornsakul P et al. · Complementary therapies in medicine (2024)
6 RCTs (339 participants); hibiscus did not significantly reduce body weight (MD −0.27 kg, P>0.05)
No significant effect on BMI (MD −0.06 kg/m², 95%CI −0.58 to 0.47)
No significant effect on waist circumference (MD −0.20 cm, 95%CI −2.06 to 1.66)
Hibiscus sabdariffa supplementation significantly reduced total cholesterol and LDL cholesterol in patients with metabolic syndrome and related disorders.
Zhang B et al. · Phytotherapy research : PTR (2020)
Meta-analysis focused on metabolic syndrome populations showed significant LDL and total cholesterol reductions
No statistically significant effect on triglycerides or HDL in pooled analyses
Effects were most consistent in populations with pre-existing dyslipidemia
Based on the literature, this review provides a thorough analysis of the pharmacological and phytochemical characteristics of Hibiscus sabdariffa.
Ekka R, Ahirwar B. · Recent advances in inflammation & allergy drug discovery (2025)
Hibiscus sabdariffa has been reported to have anti-inflammatory effects due to the presence of polyphenol compounds that possess anti- inflammatory properties.
Flavonoids are also commonly found in it, which inhibit the transcription factor nuclear factor kappa B.
This plant has a variety of health benefits, including antioxidant, antidepressant, diuretic, antihyperlipidemic, anti-obesity, hepatoprotective, anti-inflammatory, anti-cancer, antimicrobial, and neuroprotective activities.
Oral VC-H1 supplementation significantly improved skin hydration, elasticity, and wrinkle reduction, suggesting its potential as a plant-based alternative to traditional collagen supplements for skin rejuvenation.
Baek Y, Nguyen NH, Lee YI, Jung MJ, Kim IA, Lee SJ, Kim HM, Lee JH. · International journal of molecular sciences (2025)
VC-H1 supplementation significantly increased skin hydration, reduced the TEWL and keratin index, and improved deep moisture content for those receiving it compared with the controls.
Wrinkle depth significantly decreased, and skin elasticity also improved.
Oral VC-H1 supplementation significantly improved skin hydration, elasticity, and wrinkle reduction, suggesting its potential as a plant-based alternative to traditional collagen supplements for skin rejuvenation.
Future research should focus on identifying commonly used herbs, especially in resource-limited countries with poor HTN management, and additional clinical research is required to assess the toxicity and safety of commonly used HMs.
Choi D, Im HB, Choi SJ, Han D. · Frontiers in pharmacology (2024)
Results This study analyzed 37 cross-sectional studies from 21 countries and found that 37.8% of HTN patients used HM to manage their health.
However, four herbs were identified as contraindicated, 50 herbs required caution, and only 11 herbs were considered safe for use.
Conclusion The study highlights the potential risks of toxicities and adverse effects associated with HM use in the treatment of HTN.
H. sabdariffa contains several of these compounds; therefore, more studies are needed to establish its effect against H. pylori .
Espinosa-Sánchez A, Montaño-Estrada LF, Rendón-Huerta EP, Navarrete-Peón A, Gómez-Aldapa CA, Muñóz-Pérez VM, Castro-Rosas J. · Journal of medicinal food (2024)
Most gastric cancers (95%) are related to an initial Helicobacter pylori infection worldwide.
In general, studies show that natural products, such as plant-derived bioactive compounds, can be used as alternative treatments from natural origin against the pathogen.
The specific action mechanism of these bioactive compounds is still controversial, but it is suggested that they have an anti-inflammatory effect, and they also act as antibiotic coadjutants.
A Cochrane review found INSUFFICIENT evidence to determine roselle's effectiveness for hypertension (very low certainty; only one small qualifying RCT).
Pattanittum P et al. · The Cochrane database of systematic reviews (2021)
Only 1 RCT (60 participants) met inclusion criteria
SBP change +1.65 mmHg (95% CI −7.89 to 11.19), non-significant
DBP change non-significant; certainty of evidence very low
Supplementation with Diuripres® (containing Hibiscus sabdariffa) significantly reduced systolic and diastolic blood pressure and improved vascular health markers in individuals with high-normal or stage I hypertension.
Fogacci F et al. · Phytotherapy research : PTR (2023)
RCT with Hibiscus-containing combination supplement significantly reduced SBP and DBP in high-normal/stage I hypertension
Improvements in vascular health parameters including endothelial function markers
Favorable metabolic parameter changes including lipid and glucose modulation
Hibiscus sabdariffa modulates innate and adaptive immune responses through multiple pathways including NF-κB inhibition, cytokine regulation, and oxidative stress reduction.
Umeoguaju FU et al. · Frontiers in immunology (2021)
Systematic review identified multiple immune-modulating mechanisms of Hibiscus sabdariffa
Suppression of NF-κB signaling reduces pro-inflammatory cytokine production including TNF-α and IL-6
Anthocyanins and polyphenols modulate both innate and adaptive immune responses