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Ha5.5
Hyaluronic Acid – Forschung
Überwiegend Mechanismus / Beobachtung
13 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Hyaluronic Acid sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2012–2026 mit einer typischen Studiengröße von 623 Teilnehmenden.
Basierend auf 13 Studien · 7 Meta-Analysen · 4 RCTs · 50,579 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen· 12 weitere ohne bewertete Effektdaten
Nach Outcome
Joint pain & arthritisStellt die Viskosität der Synovialflüssigkeit wieder her und reduziert Knieschmerzen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung13 Studien
Skin healthVerbesserte Hautfeuchtigkeit und reduzierte Trockenheit (orale HA) · 8-12 Wochen · Moderate Reduktion der Faltentiefe in einigen Studien · 8-12 Wochen · Erhöht die Hautfeuchtigkeit und reduziert die Faltentiefe · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
In Zahlen
Aus 10 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
51k
typische Studie: 623 Personen
Stärkste Designs
11
7 gepoolt, 4 randomisiert
Zeigte Nutzen
100%
1/1 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
1
Untersuchte Populationen
Patients with knee osteoarthritis2
Adults seeking anti-aging benefits2
Patients with facial atrophic acne scars1
osteoarthritis patients1
Aktives Forschungsgebiet
10 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
201220192026
1Meta-AnalyseCited 3×n=5,089 · very large study2025
These findings emphasize the sustained efficacy of PRP, particularly when combined with HA, in providing superior long-term pain relief and functional improvement in knee OA compared to other intra-articular injectables, highlighting its potential as a preferred treatment modality.
Gupta N et al. · Journal of orthopaedic surgery and research (2025)
These findings emphasize the sustained efficacy of PRP, particularly when combined with HA, in providing superior long-term pain relief and functional improvement in knee OA compared to other intra-articular injectables, highlighting its potential as a preferred treatment modality.
2Pain and function scoresMeta-AnalyseCited 20×n=9,338 · very large study2024
At a minimum 6-month follow-up, PRP demonstrated significantly improved pain and function for patients with knee osteoarthritis compared with placebo.
Jawanda H et al. · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2024)
The most studied intra-articular injection was HA (40.9%), followed by placebo (26.2%), PRP (21.5%), CS (8.8%), and then BMAC (2.5%).
HA and PRP both led to a significant improvement in pain compared with placebo.
HA, PRP, and BMAC all led to a significant improvement in function scores when compared with placebo.
3Incidence of hyperpigmentationMeta-AnalyseCited 11×n=623 · large study2023
Zhang J et al. · Lasers in medical science (2023)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
In addition, fractional CO2 laser combined with HA dressing therapy had a lower incidence of hyperpigmentation than fractional CO2 laser alone (RR=0.37, 95% CI [0.23, 0.61], P<0.0001).
The level of evidence for outcomes was classified to be low to moderate.
According to our findings, fractional CO2 laser combined with HA dressing is efficacious and safe option for facial atrophic acne scars.
6Skin density and textureRCTCited 4×n=87 · small study2024
Therefore, the ability of supplementation with HA to improve the effects on investigated skin parameters beyond the supplementation of collagen alone cannot be confirmed.
Žmitek K et al. · Nutrients (2024)
The results showed beneficial effects of both test products, with notable enhancements in dermis density, skin texture, and a reduction in the severity of wrinkles.
In contrast, the administration of either of the products did not yield any significant impacts on skin elasticity or hydration.
Observation of the investigated skin parameters did not show superior effects of the addition of hyaluronic acid (HA) to collagen.
8Skin health conditionsRCTCited 12×n=129 · medium study2023
This study provides direct evidence supporting the clinical efficacy of oral intake of HA in promoting skin health.
Gao YR et al. · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2023)
This study provides direct evidence supporting the clinical efficacy of oral intake of HA in promoting skin health.
Oral administration of HA may improve the symptoms of knee OA in patients aged 70 years or younger when combined with the quadriceps strengthening exercise.
Tashiro T et al. · The Scientific World Journal (2012)
The symptoms of the subjects as determined by the JKOM score improved with time in both the HA and placebo groups; this improvement tended to be more obvious with the HA group, and this trend was more obvious with the subjects aged 70 years or less.
For these relatively younger subjects, the JKOM score was significantly better than the one for the placebo group at the 2nd and 4th months after the initiation of administration.
Oral administration of HA may improve the symptoms of knee OA in patients aged 70 years or younger when combined with the quadriceps strengthening exercise.
In a randomized, double-blind, placebo-controlled clinical study it was found that ingested HA increased skin moisture and improved treatment outcomes for patients with dry skin.
Kawada C et al. · Nutrition Journal (2014)
In a randomized, double-blind, placebo-controlled clinical study it was found that ingested HA increased skin moisture and improved treatment outcomes for patients with dry skin.
HA is also reported to be absorbed by the body distributed, in part, to the skin.
Ingested HA contributes to the increased synthesis of HA and promotes cell proliferation in fibroblasts.
12Skin hydration, elasticity, and wrinkle depthMeta-Analyse2025
The findings of this analysis align with existing literature, underscoring the potential of oral HA supplementation as a valuable component in anti-aging and skincare regimens.
Amin P et al. · Journal of drugs in dermatology : JDD (2025)
The meta-analysis revealed statistically significant improvements in skin hydration, elasticity, and wrinkle depth following oral HA supplementation.
Although the effects of oral HA on skin firmness, wrinkle volume, and transepidermal water loss were not statistically significant, a general trend of improvement was observed in these parameters.
The findings of this analysis align with existing literature, underscoring the potential of oral HA supplementation as a valuable component in anti-aging and skincare regimens.