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In6.0
Inulin – Forschung
Hilft wahrscheinlich
59 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Inulin scheint in 14 von 15 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2010–2026 mit einer typischen Studiengröße von 59 Teilnehmenden.
Basierend auf 59 Studien · 11 Meta-Analysen · 27 RCTs · 13,342 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
14geholfen1unklar· 44 weitere ohne bewertete Effektdaten
Nach Outcome
Digestive healthVerbesserte Darmregelmäßigkeit und Mikrobiomdiversität innerhalb von 2-4 Wochen · 2-4 Wochen
Hilft wahrscheinlich50 Studien
Weight management
Hilft wahrscheinlich18 Studien
Glucose & metabolic
Hilft wahrscheinlich12 Studien
Therapeutic & clinical
Hilft vermutlich12 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung5 Studien
InflammationVermehrung nützlicher Bakterien und verbesserte Verdauung · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Joint pain & arthritis
Zu wenige bewertete Studien2 Studien
Liver health
Zu wenige bewertete Studien1 Studie
Immune supportPräbiotische Ballaststoffe stärken die Darm-Immun-Achse über Mikrobiommodulation · 4-8 Wochen
Zu wenige bewertete Studien1 Studie
Bone health
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 43 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
92%
über Studien hinweg
Untersuchte Personen
13k
typische Studie: 59 Personen
Stärkste Designs
38
11 gepoolt, 27 randomisiert
Zeigte Nutzen
93%
14/15 Studien
Wie lange Studien liefen
1–4 Wochen
2
1–3 Monate
5
3+ Monate
5
Untersuchte Populationen
Type 2 diabetes patients2
Adults with type 2 diabetes2
General population2
COPD patients2
Aktives Forschungsgebiet
49 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
201020182026
1HbA1c reductionMeta-AnalyseCited 26×n=2,685 · very large study2023
Galactomannans were the most effective dietary fiber for reducing the levels of HbA1c, fasting blood glucose, triglycerides, and LDL cholesterol in patients with type 2 diabetes.
Juhász AE et al. · The American journal of clinical nutrition (2023)
Galactomannans had the highest effect on reducing the levels of HbA1c (SUCRA: 92.33%) and fasting blood glucose (SUCRA: 85.92%).
With regard to fasting insulin level, HOMA-IR, β-glucans (SUCRA: 73.45%), and psyllium (SUCRA: 96.67%) were the most effective interventions.
Galactomannans were ranked first in reducing the levels of triglycerides (SUCRA: 82.77%) and LDL cholesterol (SUCRA: 86.56%).
3Body weight reductionMeta-AnalyseCited 4×n=1,184 · large study2024
Chicory ITF supplementation may benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and, to a certain extent, body fat percentage.
Reimer RA et al. · The American journal of clinical nutrition (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Chicory ITF significantly reduced body weight [mean difference (MD): -0.97 kg; 95% CI: -1.34, -0.59); n = 1184] compared with placebo.
Except for considerable heterogeneity in body weight (I2: 73%) and body fat percentage (I2: 75%), all other outcomes had negligible to moderate heterogeneity.
Significant reduction in body weight, BMI, and waist circumference was evident irrespective of participants' health status.
4Bifidobacterium abundanceMeta-Analysen=2,525 · very large study2023
Chicory-derived inulin-type fructans at a dose of 3-20 g/day significantly increased Bifidobacterium abundance in participants with an age range from 0 to 83 years (standardized mean difference: 0.83, 95% CI: 0.58-1.08; p < 0.01; 50 studies; 2525 participants).
Nagy DU et al. · Critical reviews in food science and nutrition (2023)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Chicory-derived inulin-type fructans at a dose of 3-20 g/day significantly increased Bifidobacterium abundance (standardized mean difference: 0.83, 95% CI: 0.58-1.08; p < 0.01; 50 studies; 2525 participants).
Significant bifidogenic effects were observed in healthy individuals and in populations with health impairments, except gastrointestinal disorders.
Significant beneficial effects on bowel function parameters were observed in healthy subjects.
Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation, particularly in the prediabetes and T2DM population.
Wang L et al. · Journal of translational medicine (2019)
Overall, ITF supplementation could significantly reduce concentrations of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and homeostasis model assessment-insulin resistance (HOMA-IR).
Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation, particularly in the prediabetes and T2DM population.
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management.
FMT and multistrain probiotics showed superior efficacy in UC.
Zhang T et al. · Journal of gastroenterology and hepatology (2025)
FMT and multistrain probiotics showed superior efficacy in UC.
However, the efficacy of MTTs varies among different IBD subtypes and disease stages; thus, the personalized treatment strategies of MTTs are necessary.
8Clinical outcomes in cystic fibrosisSystematische ÜbersichtCited 4×2023
This review did not find any evidence for the use of prebiotics in people with CF.
Williams NC et al. · The Cochrane database of systematic reviews (2023)
This review did not find any evidence for the use of prebiotics in people with CF.
Until such evidence is available, it is reasonable for clinicians to follow any local guidelines and to discuss the use of dietary prebiotics with their patients.
Large and robust RCTs assessing the dietary prebiotics of inulin or galacto-oligosaccharides or fructo-oligosaccharides, or any combination of these, are needed.
Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.
Morsali M et al. · Journal of research in health sciences (2021)
Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.
The meta-analysis indicated that the numbers of subjects with ≥1 RTI were reduced with prebiotic (OR, 0.73; 95% CI: 0.62-0.86; P = 0.0002; n = 17) and synbiotic (OR, 0.75; 95% CI: 0.65-0.87; P = 0....
Williams LM et al. · Advances in nutrition (Bethesda, Md.) (2022)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
The meta-analysis indicated that the numbers of subjects with ≥1 RTI were reduced with prebiotic (OR, 0.73; 95% CI: 0.62-0.86; P = 0.0002; n = 17) and synbiotic (OR, 0.75; 95% CI: 0.65-0.87; P = 0.0001; n = 9) supplementation compared to placebo.
Further, NK cell activity was increased with synbiotic (standardized mean difference, 0.74; 95% CI: 0.42-1.06; P < 0.0001, n = 3) supplementation.
This review provides evidence that prebiotic, specifically oligosaccharide, supplementation may play a protective role in RTIs in infants and children.
12Short-chain fatty acid productionSystematische ÜbersichtCited 164×n=11 · very small study2022
Future studies are needed to better elucidate the relationship between DFs and gut microbiota in terms of SCFA production and impact on health-related markers.
Vinelli V et al. · Nutrients (2022)
Regarding the results obtained on the ability of fiber to modulate total SCFAs, seven studies reported a significant increase, while no significant changes were reported in five studies, depending on the analytical methodology used.
Overall, these results underline that, although affecting microbiota composition and derived metabolites, DFs do not produce univocal significant increase in SCFA levels in apparently healthy adults.
The effect of DF interventions on the SCFA profile seemed to be strictly dependent on the dose and the type and structure of DFs.
In summary, the use of ITF may have benefits for LDL-c reduction across all study populations, whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup.
Liu F et al. · European journal of clinical nutrition (2017)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
In the overall analysis, the supplementation of ITF reduced only the low density lipoprotein-cholesterol (LDL-c) (mean difference (MD): -0.15; 95% confidence interval (CI): -0.29, -0.02; P=0.03) without affecting the other endpoints.
Within the T2DM subgroup analysis, ITF supplementation was positively associated with a decreased fasting insulin concentration (MD: -4.01; 95% CI: -5.92, -2.09; P<0.0001) and increased high density lipoprotein-cholesterol (HDL-c) (MD: 0.07; 95% CI: 0, 0.14; P=0.05).
Moreover, a reduced fasting glucose tendency was identified only in the T2DM subgroup (MD: -0.42; 95% CI: -0.90, 0.06; P=0.09).
Some prebiotics and synbiotics may have immunomodulatory action, however, more randomized controlled trials are needed to support the clinical use of inulin-type fructans, galacto-oligosaccharides or related synbiotics for the treatment of metabolic endotoxaemia or low-grade inflammation in overweight/obese people.
Fernandes R et al. · Clinical nutrition (Edinburgh, Scotland) (2017)
15Pain and pain sensitivity in knee osteoarthritisRCTn=117 · medium study2026
Only inulin improved pain sensitivity and grip strength, the latter paralleled by increased GLP-1, and had much higher rates of retention compared to PSE.
Kouraki A et al. · Nutrients (2026)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Results: A total of 117 participants (58.1% female; mean ± SD age = 67.5 ± 9.4 years; BMI = 29.5 ± 5.3 kg/m2; NRS = 3.96 ± 2.67) completed the trial.
Pain improved with inulin (baseline-adjusted between-group mean difference (Δ) = -1.11 [95%CI -2.18, -0.04], p = 0.045) and PSE (Δ = -1.55 [95%CI -2.52, -0.58], p = 0.002) compared to placebo, with no synergistic effect.
PSE improved TUG (p = 0.02) and 30-CST (p = 0.0004), while inulin improved grip strength (p = 0.002), pressure pain thresholds (p = 0.009) and temporal summation (p = 0.025) compared to placebo and had significantly lower dropout rates (3.6%) compared with PSE (21% p < 0.01).
Well-powered, placebo-controlled trials with standardized migraine endpoints and integrated microbiome and metabolomic analyses are needed to define responders, optimal interventions, and clinical relevance.
Kozák M et al. · Nutrients (2026)
Emerging evidence also supports a potential role for prebiotics (e.g., inulin-type fructans) and microbiota-derived metabolites such as short-chain fatty acids, although direct clinical data remain limited.
Conclusions: Modulation of the microbiome-gut-brain axis represents a biologically plausible adjunct approach in migraine management.
While probiotics, prebiotics, and postbiotics show potential benefits with favorable safety profiles, current evidence of their strain-, formulation-, and population-specific characteristics is lacking.
Zang J et al. · Comprehensive reviews in food science and food safety (2026)
In the colon, fermentable carbohydrates, such as inulin, and fructooligosaccharides promote microbial fermentation and short-chain fatty acid (SCFA) production-especially butyrate-which strengthens epithelial integrity, stimulates mucus secretion, and regulates immune responses.
Finally, this review emphasizes the need to assess coordinated dietary effects along the entire small-to-large intestine continuum to better guide targeted nutritional strategies for human health.
18Gut health modulationSystematische Übersichtn=22 · very small study2026
Prebiotics are effective modulators of gut health, driving clinical benefits through selective microbial fermentation and SCFA production.
Monteiro CRAV et al. · Nutrients (2026)
Prebiotics are effective modulators of gut health, driving clinical benefits through selective microbial fermentation and SCFA production.
The documented heterogeneity and variability highlight the need for future research to focus on personalized nutritional strategies.
Key priorities include standardizing intervention protocols, elucidating dose-response relationships, integrating multi-omics data to link taxonomy to function, and exploring novel applications such as synbiotic formulations and gut-brain axis modulation.
19Inflammatory markers in diabetesMeta-Analysen=46 · small study2025
Strain- and dose-standardized RCTs should confirm impacts on glycemic and cardiometabolic outcomes.
Xie Y, Zheng Y, Jiang F, Cai X. · Frontiers in cellular and infection microbiology (2025)
Groß Nutzen
← SchlechterKein EffektBesser →
Results Probiotic/synbiotic interventions led to significant reductions in CRP (SMD = -0.54), IL-6 (SMD = -0.41), and TNF-α (SMD = -0.48), along with an increase in IL-10 (SMD = +0.38).
SCFA levels rose significantly, with butyrate showing the strongest effect (SMD = +0.46).
Multi-strain and synbiotic interventions were more effective than single-strain or probiotic-only formulations.
Findings advocate integrating inulin-rich foods/supplements into prevention strategies for precision prebiotic development via SCFA-mediated epigenetic and antitumor mechanisms.
Yu Y, He J, Fu H, Mi Y, Wu H, Gao Y, Li M. · Journal of food science (2025)
Standardized meta-analyses were performed for eligible studies.
This systematic review demonstrates inulin's chemopreventive effects against CRC in animal models by enhancing beneficial gut bacteria (e.g., lactobacillus) and boosting SCFAs.
Findings advocate integrating inulin-rich foods/supplements into prevention strategies for precision prebiotic development via SCFA-mediated epigenetic and antitumor mechanisms.