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Kro6.5
Krill Oil – Forschung
Überwiegend Mechanismus / Beobachtung
23 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Krill Oil sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2017–2026 mit einer typischen Studiengröße von 262 Teilnehmenden.
Basierend auf 23 Studien · 5 Meta-Analysen · 4 RCTs · 10,271 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Joint pain & arthritisZwei RCTs zeigen moderate Verbesserungen bei Kniearthrose-Schmerz, -Steifheit und -Funktion über 3-6 Monate · 3-6 Monate
Überwiegend Mechanismus / Beobachtung8 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressureMetaanalysen zeigen moderate Senkungen von LDL und Triglyceriden; kein Effekt auf Blutdruck oder Entzündungsmarker · 4-12 Wochen
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
22 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
20172026
1Systematische Übersicht2026
Formulations with high amounts of DHA in the form of PLs offer higher bioavailability but are more expensive than other formulations.
Alvear I, Duarte L, Farias C, Videla LA, Muñoz Y, Valenzuela R. · Critical reviews in food science and nutrition (2026)
Formulations with high amounts of DHA in PLs form, such as krill oil supplements, have a higher bioavailability than common TG-based fish oil.
Ethyl ester formulations, although more stable to oxidative processes, depend on pancreatic enzyme activity and lipid intake at each meal to ensure absorption.
DHA deposits in tissues such as heart, liver and brain correlate with bioavailability, with PLs and TGs of DHA being found in the highest amounts in these tissues, making the bioavailability of n-3 PUFAs supplements a challenge for the pharmaceutical industry.
However, further large-scale, well-designed randomized controlled trials (RCTs) are needed to confirm these findings, particularly those that include more standardized dosages and formulations, as well as to evaluate their long-term efficacy.
Zhang Y, Gui Y, Adams R, Farragher J, Itsiopoulos C, Bow K, Cai M, Han J. · Nutrients (2025)
Bayesian rankings indicated Boswellia had the highest probability of being most effective for pain and stiffness, with krill oil and curcumin showing potential for function improvement.
Conclusions : Nutritional supplements, particularly Boswellia, appear to be effective and well-tolerated for improving KOA symptoms and function.
These results suggest that certain supplements may be useful as part of non-pharmacological KOA management.
Conclusion Krill oil presents as a promising safe therapeutic option for knee osteoarthritis; however, its efficacy in pain relief requires further investigation.
Meng J, Wang X, Li Y, Xiang Y, Wu Y, Xiong Y, Liu P, Gao S. · Medicine (2025)
Analysis of blood markers also revealed no significant effects of krill oil group compared to the usual care group.
Moreover, adverse events in the krill oil group and usual care group also showed no statistical difference.
The safety profiles were similar between the 2 groups.
It explores its influence on glucose homeostasis, oxidative stress responses, inflammatory pathways, lipid metabolism, and muscle physiology.
Attri N, Arora D, Saini R, Chandel M, Suthar P, Dhiman A. · Food science and biotechnology (2025)
Additionally, advancements in encapsulation technologies aim to optimize the delivery and efficacy of krill oil supplements.
The review outlines the selection of emulsifiers and wall materials, along with techniques employed in creating four novel encapsulation methods for krill oil: micro/nanoemulsions, microcapsules, liposomes, and nanostructured lipid carriers.
The review also provides scientific literature on the physiological impacts and underlying mechanisms of krill oil supplementation.
Based on these findings, krill oil supplementation is not yet justified for knee pain.
Pimentel T, Queiroz I, Florêncio de Mesquita C, Gallo Ruelas M, Leandro GN, Ribeiro Monteiro A, Nunes Pimentel F. · Inflammopharmacology (2024)
A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used.
Conclusion This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function.
Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles.
This study systematically reviews the impact of krill oil and its active components on adipose tissue function, with the aim of providing more effective lifestyle intervention strategies for the prevention and management of obesity and metabolic diseases.
Tang W, Yin X. · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] (2025)
In recent years, the global prevalence of obesity has shown a persistent upward trajectory, including significant increases within China.
The implementation of diversified intervention strategies aimed at weight reduction and adipose tissue functional improvement represents an effective paradigm for preventing and managing obesity-related metabolic disorders.
Although not powered to detect clinical efficacy (which is acceptable in exploratory pilot trials), the study supports the feasibility of a larger trial and highlights the potential of dietary interventions in the management of HF.
de Abreu-Silva EO, Machado RHV, Dos Santos BR, Kojima FCS, Santos RHN, Negrelli KDL, Rodrigues LB, de Barros E Silva PGM, de Lima AG, Sanchez JG, El Khouri FJ, Bersch-Ferreira ÂC, Carvalho AB, de Oliveira TM, Izar MC, Sampaio GR, Damasceno NRT, Rogero MM, Torres EAFDS, Cartolano FC, Krey JP, de Luca PV, Amaral CK, Dos Santos EM, de Melo RMV, Lima EG, Dos Santos AL, Heck TG, Carvalho APPF, Garofallo SB, Cavalcanti AB, Marcadenti A. · Nutrients (2025)
Results: Mean age was 54.5 ± 13.7 years, and 58.6% were women.
Both adherence to protocol (91.8% attendance; 79.1% investigational product intake) and retention (86.2%) were high.
However, regardless of allocation to active supplementation or placebo, a significant reduction in Lp(a) concentrations was observed following the DICA-FH intervention (median difference: -3.8 mg/dL [interquartile range: -7.5 to -1.2]; p < 0.01).
Further comparative studies examining dose-dependent effects, bioavailability kinetics, and tissue-specific molecular pathways are warranted.
Sarıyer ET, Baş M, Yüksel M. · International journal of molecular sciences (2025)
Both oils exert antioxidant and anti-inflammatory activities, aligning with the review focus.
The bioactivities of both oils stem from their distinct molecular compositions: KO delivers EPA/DHA via phospholipids, alongside astaxanthin, while FO provides EPA/DHA bound to triglycerides.
In some cases, they exhibit similar outcomes, whereas in others, one may be more effective than the other.
Trial registration Australian New Zealand Clinical Trials Registry Identifier: ACTRN12616000726459; Universal Trial Number: U1111-1181-7087.
Laslett LL, Scheepers LEJM, Antony B, Wluka AE, Cai G, Hill CL, March L, Keen HI, Otahal P, Cicuttini FM, Jones G. · JAMA (2024)
Results Of 262 participants randomized (mean age, 61.6 [SD, 9.6] years; 53% women), 222 (85%) completed the trial.
Krill oil did not improve knee pain compared with placebo (mean change in VAS score, -19.9 [krill oil] vs -20.2 [placebo]; between-group mean difference, -0.3; 95% CI, -6.9 to 6.4) over 24 weeks.
One or more adverse events was reported by 51% in the krill oil group (67/130) and by 54% in the placebo group (71/132).
This review provides an overview of existing studies on the beneficial impact of KO on the skin, exploring its functional roles and underlying mechanisms through which it contributes to dermatological health and disease management.
Duo L, Yang J, Wang X, Zhang G, Zhao J, Zou H, Wang Z, Li Y. · Frontiers in nutrition (2024)
KO has various benefits, including antioxidative, anti-inflammatory, metabolic regulatory, neuroprotective, and gut microbiome modulatory effects.
Especially, the antioxidant and anti-inflammatory effects make KO have potential in skin care applications.
With increasing demands for natural skin anti-aging solutions, KO has emerged as a valuable nutraceutical in dermatology, showing potential for mitigating the effects of skin aging and enhancing overall skin health and vitality.
Salmon J, Wallace DJ, Rus V, Cox A, Dykas C, Williams B, Ding Y, Hals PA, Johnsen L, Lipsky PE. · Lupus science & medicine (2024)
The baseline Omega-3 Index in the total SLE cohort was a mean 4.43% (±SD 1.04%).
After 4 weeks of KOC treatment, the Omega-3 Index rapidly increased to 7.17%±1.48% (n=38) and after 24 weeks to 8.05%±1.79% (n=25) (each p<0.001 vs baseline), whereas no significant change from baseline was noted in patients receiving placebo.
After patients switched from placebo to KOC at 24 weeks, the mean Omega-3 Index showed a rapid and significant increase (from 4.63%±1.39% at week 24 (n=26) to 7.50%±1.75% at week 48 (n=12); p<0.001).
In 235 adults with mild-to-moderate knee OA, 4g/day krill oil for 6 months produced modest but significant improvements in knee pain, stiffness, and physical function versus placebo, and raised the Omega-3 Index from 6.0% to 8.9%.
Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, Hill CL · Am J Clin Nutr (2022)
Pooling 14 RCTs (1,458 participants), krill oil supplementation significantly improved total cholesterol, LDL cholesterol, and triglycerides, but had no effect on blood pressure, glycemic control, body composition, or inflammatory markers.
Huang H, Liao D, He B, Zhou G, Cui Y · Diabetes Metab Syndr (2023)
14 RCTs (18 treatment arms), 1,458 participants
Beneficial effects on total cholesterol (P=0.01), LDL-C (P=0.006), triglycerides (P=0.0005)
No effect on blood pressure, glycemic indices, body composition, or inflammatory markers
Across 7 RCTs (662 participants), krill oil significantly lowered LDL cholesterol (-15.5 mg/dL) and triglycerides (-14.0 mg/dL) and raised HDL (+6.65 mg/dL), while the reduction in total cholesterol was not significant.
Ursoniu S, Sahebkar A, Serban MC, Antal D, Mikhailidis DP, Cicero A, et al. · Nutr Rev (2017)
7 RCTs (14 treatment arms), 662 participants
LDL-C reduced by 15.52 mg/dL (95% CI -28.43 to -2.61)
Triglycerides reduced by 14.03 mg/dL (95% CI -21.38 to -6.67)
Hayman O, Alkhedhairi SA, Combet E, Quinn TJ, Hunter AM, Goodall S, Gray SR. · The journal of nutrition, health & aging (2026)
Increases in muscle strength, size, and physical function in response to krill oil supplementation were comparable across age, sex and BMI subgroups (all P > 0.05).
In conclusion, krill oil supplementation improved muscle strength and size in older adults regardless of age, sex and BMI status, although neuromuscular effects of krill oil on membrane excitability, via the Mwave, may be more pronounced in men.
However, there was no evidence of apparent superiority over each other.
Açik M, Çakiroğlu FP, Tekin A, Egeli A. · Journal of affective disorders (2025)
The mean HDRS scores decreased significantly in both the krill-oil (8.5 ± 1.2) and fish-oil groups (10.0 ± 1.2) compared to the placebo (p < 0.001), indicating clinical symptom improvement.
Furthermore, the interaction effect of group-by-time was found to be statistically significant (η2p = 0.273;p time×group < 0.001).
Krill- and fish-oil supplementation increased plasma HDL-c and uric acid levels, but the group-by-time interaction effect was only observed at the HDL-c level (η2p = 0.238;p time×group = 0.002).
This review aims to provide an overview of the beneficial effects of krill oil and its bioactive components on intestinal inflammation and to discuss the findings on the molecular mechanisms associated with the role of krill oil in IBD prevention and treatment.
Liu Y, Robinson AM, Su XQ, Nurgali K. · Biomolecules (2024)
Recent experimental and clinical studies suggest that it has potential therapeutic benefits in preventing the development of a range of chronic conditions, including inflammatory bowel disease (IBD).
Krill oil is enriched with long-chain n-3 polyunsaturated fatty acids, especially eicosapentaenoic and docosahexaenoic acids, and the potent antioxidant astaxanthin, contributing to its therapeutic properties.
The possible underlying mechanisms of krill oil's health benefits include anti-inflammatory and antioxidant actions, maintaining intestinal barrier functions, and modulating gut microbiota.