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Lmb5.8
Lemon Balm – Forschung
Hilft vermutlich
34 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Lemon Balm half in etwa der Hälfte (2/3) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2004–2026 mit einer typischen Studiengröße von 70 Teilnehmenden.
Basierend auf 34 Studien · 4 Meta-Analysen · 17 RCTs · 10,423 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen1unklar· 31 weitere ohne bewertete Effektdaten
Sleep & insomniaVerbessertes Einschlafen und bessere Schlafqualität · 30-60 Minuten · Rosmarinsäure hemmt die GABA-Transaminase, um den Schlaf zu vertiefen · 1-2 Wochen
Überwiegend Mechanismus / Beobachtung10 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung7 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung6 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung5 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung5 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung5 Studien
Women's healthKann bei der Behandlung von Wechseljahrsbeschwerden wie Hitzewallungen und Stimmungsschwankungen helfen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Depression & moodBeruhigende Wirkungen verringern Unruhe und verbessern die Stimmung · 2-4 Wochen
Zu wenige bewertete Studien2 Studien
Cold sores & HSV
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 20 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
75%
über Studien hinweg
Untersuchte Personen
10k
typische Studie: 70 Personen
Stärkste Designs
21
4 gepoolt, 17 randomisiert
Zeigte Nutzen
67%
2/3 Studien
Wie lange Studien liefen
1–4 Wochen
2
1–3 Monate
1
Untersuchte Populationen
General population2
Patients with herpes labialis1
Type 2 diabetes patients1
Patients with dyslipidemia1
Aktives Forschungsgebiet
19 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200420152026
1Herpes labialis healing time and symptom reductionSystematische ÜbersichtCited 2×n=1,250 · large study2025
Future well-designed, large-scale RCTs employing standardized methodologies are necessary to confirm these findings and to establish optimal treatment protocols for diverse patient populations (Inplasy protocol number: 202350038).
Anheyer M et al. · Journal of integrative and complementary medicine (2025)
Lemon balm preparations consistently reduced pain intensity and swelling, with some studies also reporting a significant decrease in lesion size compared with placebo or acyclovir.
Olive leaf extract demonstrated a statistically significant faster improvement in symptoms and a shorter healing time compared with acyclovir.
Discussion: The findings indicate that topical herbal therapies may provide effective and well-tolerated alternatives or adjuncts to conventional antiviral treatments for herpes labialis.
3Serum lipid profile improvementMeta-AnalyseCited 3×n=302 · medium study2024
The findings of this meta-analysis provide evidence that lemon balm may be administered as a safe and beneficial herbal medicine for reducing TC, TG and LDL levels.
Shahsavari K et al. · BMC complementary medicine and therapies (2024)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Could be chance
While it had no statistically significant effect on HDL level (SMD (95% CI): 0.336(-0.091, 0.767), p-value = 0.123).
The findings of this meta-analysis provide evidence that lemon balm may be administered as a safe and beneficial herbal medicine for reducing TC, TG and LDL levels.
According to the pooled results of 5 studies with a total of 302 patients, lemon balm intake had no significant effect on HDL level.
4Herbal remedies effect on GABAergic system and sleepSystematische ÜbersichtCited 66×2021
Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.
Bruni O et al. · Nutrients (2021)
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states.
GABA receptors are the targets of many pharmacological treatments for insomnia, such as benzodiazepines.
Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control.
5Anxiety and depression scoresMeta-AnalyseCited 28×2021
Further high-quality studies are needed to firmly establish the clinical efficacy of the lemon balm.
Ghazizadeh J et al. · Phytotherapy research : PTR (2021)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Based on meta-analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: -0.98; 95% CI: -1.63 to -0.33; p = 0.003), (SMD: -0.47; 95% CI: -0.73 to -0.21; p = 0.0005) respectively, without serious side effects.
Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting.
Due to the high level of heterogeneity between studies, results should be interpreted with caution.
Collectively, the literature reveals preclinical and clinical evidence for various phytomedicines modulating GABA-pathways, with comparative anxiolytic effect to the current array of pharmaceuticals, along with good safety and tolerability profiles.
Savage K et al. · Phytotherapy research : PTR (2018)
An open-ended search to 5 July 2017 was conducted using MEDLINE (PubMed), Scopus, and Cochrane library online databases and performed in a stepped format from preclinical to clinical investigations.
Eligible studies must have had (a) in vitro evidence of GABA-modulating activity, (b) animal studies using anxiety models to test an anxiolytic effect, and (c) human clinical trials.
Ten phytomedicines were identified as having preclinical investigations showing interaction with the GABA system, in addition to human clinical trials: kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm.
High-quality RCTs are needed for firm conclusions concerning the effects of MO on cardiometabolic outcomes.
Heshmati J et al. · Phytotherapy research : PTR (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Random-effects meta-analyses estimated the pooled standardized mean differences (SMD) between intervention and control groups.
MO intake was associated with a reduced total cholesterol (TC) (SMD: -0.26; 95% CI: -0.52, -0.01; I2 = 13.7%; k = 6) and a reduced systolic blood pressure (SBP) (SMD: -0.56; 95% CI: -0.85, -0.27; I2 = 00.0%; k = 3).
MO intake was not associated with statistically significant changes in triglycerides, low-density lipoprotein, diastolic blood pressure, high sensitivity c-reactive protein levels, fasting blood sugar, HbA1c, insulin or high-density lipoprotein levels.
8Pharmacological effects of lemon balmSystematische Übersicht2025
This review presents a critical synthesis of existing knowledge and future directions for integrating M. officinalis into nutraceutical, pharmaceutical, and cosmetic products.
Awlqadr FH, Altemimi AB, Qadir SA, Mohammed OA, Saeed MN, Hesarinejad MA, Lakhssassi N. · Food science & nutrition (2025)
Recent investigations have also shown its wide-ranging pharmacological potential, which includes antioxidant, antimicrobial, anti-inflammatory, neuroprotective, antiviral, antidepressant, anxiolytic, anticancer, cardioprotective, and cognitive-enhancing properties.
Furthermore, the traditional medicinal use of M. officinalis in managing neurodegenerative conditions such as stroke, epilepsy, dementia, and paralysis is increasingly supported by contemporary evidence, highlighting its therapeutic relevance in brain-related disorders.
However, further studies are necessary to refine extraction methods, standardize levels of bioactive compounds, and validate clinical applications.
9Cognition and sleep qualitySystematische Übersicht2025
It is concluded that lemon balm has the potential to improve cognition and sleep quality; however, robust evidence is needed, as more rigorous trials are required.
Oliveira MVB, Garguerra JA, Lamas CB, Laurindo LF, Rodrigues VD, Sloan KP, Sloan LA, Chagas EFB, Guiguer EL, Detregiachi CRP, Miglino MA, Pereira ESBM, Valenti VE, Silva LR, Barbalho SM. · International journal of molecular sciences (2025)
Regarding sleep, a combination of lemon balm and valerian significantly improved sleep quality in postmenopausal women.
Isolated lemon balm extracts also reduced sleep disorders in cardiac patients.
When compared to citalopram, lemon balm enhanced the quality of life, including sleep quality.
Results/conclusions Although further robust randomised controlled trials using lemon balm are required, existing research indicates that lemon balm holds promise as a calming agent exhibiting both anxiolytic and anti-depressant properties and can elicit cognitive and sleep-quality enhancement.
Mathews IM, Eastwood J, Lamport DJ, Cozannet RL, Fanca-Berthon P, Williams CM. · Nutrients (2024)
One herb that is receiving growing attention is lemon balm ( Melissa officinalis L.) which has received considerable interest for its influence on the brain.
Lemon balm boasts an array of phytochemicals, including rosmarinic acid, citral, oleanolic acid, and ursolic acid, which are believed to underpin these effects on psychological well-being.
Pharmacological evidence from animal and cellular work reveals that lemon balm and its components may modulate several brain signalling pathways, including GABAergic, cholinergic, and serotonergic systems.
11Evidence synthesis for Melissa officinalisSystematische ÜbersichtCited 22×2005
An evidence-based systematic review including written and statistical analysis of scientific analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetic/dynamics, interactions, adverse effect, toxicology, and dosing.
Ulbricht C et al. · Journal of herbal pharmacotherapy (2005)
An evidence-based systematic review including written and statistical analysis of scientific analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetic/dynamics, interactions, adverse effect, toxicology, and dosing.
Further research warranted to confirm findings
12RCTCited 24×n=44 · small study2023
After 12-week the mean change of depression and anxiety scores were statistically significant between the two groups (p < 0.001 and p = 0.04, respectively), but no significant differences were observed in FBS, hs-CRP, anthropometric indices, sleep quality, and blood pressure.
Safari M et al. · BMC complementary medicine and therapies (2023)
M. officinalis extract 700 mg/day significantly reduced depression (p < 0.001) and anxiety (p = 0.04) scores versus placebo over 12 weeks in type 2 diabetes patients with depression
No significant between-group differences were seen for fasting blood sugar, hs-CRP, anthropometric indices, sleep quality, or blood pressure
According to the results, M. officinalis can reduce systolic and diastolic blood pressures of the patients with essential hypertension.
Shekarriz Z et al. · Phytotherapy research : PTR (2021)
Moreover, it was found that systolic and diastolic blood pressures significantly decreased after the consumption of M. officinalis, compared to placebo.
Also, no significant side effects were observed during the study.
According to the results, M. officinalis can reduce systolic and diastolic blood pressures of the patients with essential hypertension.
Among adults with impaired sleep, a nutraceutical combination did not improve objective or subjective sleep parameters more than a placebo infusion.
Gutiérrez-Romero SA et al. · Scientific reports (2024)
Mean sleep efficiency remained unmodified in the active group, and increased by 3% in the placebo group, the between-group difference in the change was not statistically significant (p = 0.49).
Time wake after sleep onset (WASO) decreased more in the active group (4.6% vs. 2.4%), but the difference was not significant (p = 0.33).
Mean PSQI decreased by 3.11 points (32.3%) in the active group, and by 3.86 points (39.5%) in the placebo group (p = 0.41).
The results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance.
Shirazi M et al. · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2021)
The mean for all MENQOL domain scores were significantly improved in the M. officinalis group compared with citalopram and placebo.
M. Officinalis L. (combined with fennel fruit extract) may be recommended for improving the quality of life of menopausal women with sleep disturbance.
19Heart palpitation episodesRCTCited 33×n=71 · small study2015
Lyophilized aqueous extract of M. officinalis leaves may be a proper and safe herbal drug for the treatment of benign palpitations.
Alijaniha F et al. · Journal of ethnopharmacology (2015)
Likely real
Results showed that 14-day of treatment with lyophilized aqueous extract of M. officinalis leaves reduced frequency of palpitation episodes and significantly reduced the number of anxious patients in comparison to the placebo (P=0.0001, P=0.004 resp.).
Lyophilized aqueous extract of M. officinalis leaves may be a proper and safe herbal drug for the treatment of benign palpitations.
M. officinalis is safe and effective in improvement of Apo A-I, Apo B/Apo A-I, and lipids ratios as key factors promoting cardiovascular disease (CVD) in type II diabetic patients.
Asadi A et al. · Complementary therapies in medicine (2018)
Although both groups showed a significant reduction in ICAM-1, AST and, ALP (p < 0.05), no significant differences in ICAM-1, AST and, ALP were observed.
M. officinalis is safe and effective in improvement of Apo A-I, Apo B/Apo A-I, and lipids ratios as key factors promoting cardiovascular disease (CVD) in type II diabetic patients.