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Lt4.0
Luteolin – Forschung
Hilft wahrscheinlich
62 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Luteolin scheint in 4 von 4 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2013–2026 mit einer typischen Studiengröße von 185 Teilnehmenden.
Basierend auf 62 Studien · 4 Meta-Analysen · 14 RCTs · 6,334 Teilnehmende insgesamt
InflammationReduzierte systemische und neuronale Entzündung · 2-4 weeks
Überwiegend Mechanismus / Beobachtung29 Studien
Therapeutic & clinical
Hilft wahrscheinlich16 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung12 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung5 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung5 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung4 Studien
Immune supportReduzierte allergische Reaktionen und Mastzellaktivität · 2-4 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Cholesterol & lipids
Zu wenige bewertete Studien2 Studien
Liver health
Zu wenige bewertete Studien2 Studien
Depression & mood
Zu wenige bewertete Studien1 Studie
Anxiety & stressAnxiolytische Eigenschaften über GABAerge und anti-neuroinflammatorische Signalwege · 2-4 weeks
Zu wenige bewertete Studien1 Studie
Energy & fatigue
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 36 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
6,334
typische Studie: 185 Personen
Stärkste Designs
18
4 gepoolt, 14 randomisiert
Zeigte Nutzen
100%
4/4 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
3
Untersuchte Populationen
Neurodegenerative disease patients2
Not specified2
Idiopathic pulmonary fibrosis patients1
Animal models with chemical-induced liver damage1
Aktives Forschungsgebiet
55 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
201320192026
1Systematische Übersichtn=1,140 · large study2023
Einfach gesagt: The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
Weng J et al. · Annals of medicine (2023)
The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
NPAs identified seven hub TCM and 13 target genes associated with their actions, while bioinformatics analysis identified two DEGs between normal and CAG gastric tissues.
Finally, molecular docking was employed to reveal the mechanism of action of the active molecules in TCM on the DEGs.
2Idiopathic pulmonary fibrosis treatment efficacyMeta-Analysen=896 · large study2024
Einfach gesagt: These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
Wu X et al. · Medicine (2024)
These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
The utilization of natural products holds significant promise for the prevention and treatment of neurodegenerative diseases (ND).
The review provides evidence that natural products and their bioactive compounds could be beneficial in the treatment of neurodegenerative disorders.
This article delineates the Keap1-Nrf2-ARE pathway's role in ND progression, shedding light on the therapeutic efficacy of natural products and their bioactive constituents that have demonstrated neuroprotective properties.
Einfach gesagt: The primary focus of this systematic review is to analyze the current state of the literature regarding treating liver ailments using extracts from medicinal plants, examining their phytochemical composition, and addressing associated safety considerations.
Gonfa YH et al. · Zeitschrift fur Naturforschung. C, Journal of biosciences (2025)
The application of natural products derived from medicinal plants in treating liver injuries is rooted in their efficacy, cost-effectiveness, and safety profile, contributing to their popularity.
Many studies, encompassing in vitro, in vivo, preclinical, and clinical investigations, have demonstrated that the extracts of medicinal plants mitigate chemical-induced liver damage using animal models.
However, intensive research efforts regarding the safety, regulatory standard, and quality control issues for using medicinal plants as hepatoprotective agents remain the strong task of scholars.
Einfach gesagt: Both natural and synthetic NRF2 activators mitigate toxic lipid accumulation and oxidative injury, supporting NRF2 modulation as a promising strategy for preventing and treating lipid metabolic disorders such as NAFLD, atherosclerosis, and metabolic syndrome.
Arif Asghar M et al. · Journal of biochemical and molecular toxicology (2025)
Groß Nutzen
← SchlechterKein EffektBesser →
Clinical meta-analysis demonstrated that NRF2 activators reduced toxic lipid parameters, including triglycerides (↓ 21.81%), LDL (↓ 18.36%), and total cholesterol (↓ 14.15%).
Network pharmacology identified 985 overlapping genes linking NRF2 activation to oxidative stress, lipid peroxidation, and fatty acid metabolism.
Sixteen natural and synthetic NRF2 activators were highlighted, with molecular docking showing strong KEAP1 binding by quercetin (-9.2 kcal/mol) and luteolin (-9.2 kcal/mol), consistent with disruption of KEAP1-NRF2 interactions and detoxification pathway activation.
7Neuroprotection in brain and spinal cord injurySystematische Übersicht2025
Faysal M et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
Flavonoids can enhance injury healing, reduce lesion size, and enhance synaptic plasticity and neurogenesis.
The full potential of flavonoids lies in their bioavailability, dose, and administration methods, but there are still challenges to overcome.
This review explores flavonoid-induced neuroprotection, its clinical implications, future research opportunities, and molecular mechanisms, highlighting the potential for innovative CNS injury therapies and improved patient health outcomes.
Einfach gesagt: So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
Cao Y et al. · Pharmacological research (2021)
So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
It is believed that more breakthrough studies are needed.
Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.
11Brain fog symptoms improvementSystematische Übersichtn=17 · very small study2024
Einfach gesagt: Two studies showed that the use of Palmitoylethanolamide and Luteolin (PEA-LUT) improved cognitive impairment.
Gorenshtein A et al. · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
Noninvasive brain stimulation and hyperbaric oxygen therapy showed promising results in the treatment of brain fog symptoms caused by long-COVID, with improved perfusion and cortical excitability.
Furthermore, both rehabilitation strategies and PEA-LUT administration have been associated with improvements in symptoms of brain fog.
Future studies should explore combinations of interventions and include longer follow-up periods to assess the long-term effects of these treatments.
15Neuroinflammation modulation in affective disordersÜbersicht2026
Einfach gesagt: Future research should prioritize bioavailability-enhanced formulations, standardized clinical trials, and biomarker-guided stratification to fully establish the therapeutic potential of flavonoids in affective disorders.
Rosas-Sánchez GU et al. · International journal of molecular sciences (2026)
This narrative review synthesizes current preclinical and clinical evidence on the role of flavonoids and related natural compounds in modulating neuroinflammation and affective disorders.
Preclinical studies consistently demonstrate anxiolytic and antidepressant effects for compounds such as quercetin, luteolin, apigenin, and chrysin; however, clinical evidence remains limited and methodologically heterogeneous.
Future research should prioritize bioavailability-enhanced formulations, standardized clinical trials, and biomarker-guided stratification to fully establish the therapeutic potential of flavonoids in affective disorders.
Einfach gesagt: The neuroprotective properties of PEA-LUT appear to enhance recovery from post-COVID olfactory dysfunction.
Shi Y et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2026)
Of the seven studies, five (71.4%) used the full Threshold-Discrimination-Identification (TDI) scoresystem to assess olfactory function, while two (28.6%) used only the Identification ("I") subscale; 332 patients (63.2%) received PEA-LUT + OT therapy and 203 (38.8%) received OT alone.
Meta-analysis of these studies showed that patients receiving PEA-LUT combined with OT had significantly higher TDI scores compared to those receiving OT alone (Standard mean difference (SMD) = 0.90; 95% CI: 0.24-1.58; P < 0.01).
The overall response rate was also significantly higher in the combination group (Risk difference (RD) = 0.33; 95% CI: 0.01-0.64; P = 0.04).
Einfach gesagt: We also suggest simple ways to address some of the key pathogenetic processes involved in ASD.
Katiraei P et al. · International journal of molecular sciences (2026)
Individuals with ASD have a constellation of neurological, behavioral, sensory, feeding, gastrointestinal, and immunological issues.
Here we discuss how various environmental, pathogenic, and stress factors can disrupt gut-brain homeostasis to create susceptibility and epigenetic effects that contribute to the development of ASD.
We also suggest simple ways to address some of the key pathogenetic processes involved in ASD.
19Allergic rhinitis and asthma outcomesÜbersicht2026
Einfach gesagt: Mapping natural compounds to specific disease stages provides a molecular basis for precision medicine approaches.
Zhang X et al. · International journal of molecular sciences (2026)
During sensitization, flavonoids (quercetin, luteolin, apigenin, baicalin) and polyphenols (curcumin, resveratrol) target the epithelial-dendritic cell axis by suppressing alarmin release and blocking dendritic cell maturation.
In acute exacerbation, flavonoids (hispidulin, quercetin) and isoquinoline alkaloids (coptisine) exhibit rapid intervention through mast cell stabilization and neurogenic inflammation suppression.
In chronic remodeling, stilbenes (resveratrol) and flavones (baicalin, baicalein) reverse established structural changes through TGF-β1/Smad, PTEN/PI3K/AKT, and PDGF-BB/PDGFR-β pathways.