Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren

Mnd5.0

Mandelic Acid (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

7 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Mandelic Acid (topical) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen Meta-Analysen und randomisierten Studien, veröffentlicht 2016–2025 mit einer typischen Studiengröße von 50 Teilnehmenden.

Basierend auf 7 Studien · 1 Meta-Analyse · 4 RCTs · 284 Teilnehmende insgesamt

Konfidenz

Mittlere Konfidenz

Nach Outcome

Safety profile
Zu wenige bewertete Studien2 Studien
Skin healthReduziert Akneläsionen vergleichbar mit anderen Säurepeelings, bei besserer Verträglichkeit (kosmetisch; überwiegend Peeling-Evidenz) · 8-12 weeks
Zu wenige bewertete Studien2 Studien
Skin tone & pigmentationVerbessert Melasma und postakneische Pigmentierung, sanfter als Glykolsäure bei dunklerer Haut (kosmetisch) · 8-12 weeks
Zu wenige bewertete Studien1 Studie

Aktives Forschungsgebiet

3 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2022

20162025

1Meta-Analyse2022

physical - chemical peels, e.g. salicylic or mandelic acid (39·70%, 95% CrI 12·54-66·78%)

Mavranezouli I, Daly CH, Welton NJ, et al. · Br J Dermatol (2022)

NICE-commissioned network meta-analysis of 179 RCTs (~35,000 observations) ranking acne treatments
Chemical peels (salicylic or mandelic) were among the effective physical options for mild-to-moderate acne (~39.7% lesion reduction vs placebo)
Uncertainty was high, particularly for chemical peels; mandelic is grouped with salicylic rather than isolated

Quelle ansehen

2Systematische Übersicht2020

There may be no difference in PGA when comparing glycolic acid peel to salicylic-mandelic acid peel (RR 1.06, 95% CI 0.88 to 1.26; 1 study, 40 participants; low-quality evidence).

Liu H, Yu H, Xia J, et al. · Cochrane Database Syst Rev (2020)

Cochrane review of 49 RCTs (3,880 participants) on topical acne agents including fruit acids
AHA-peel evidence was limited to a single small trial finding no difference between glycolic and salicylic-mandelic peels, rated low-quality
Most AHA comparisons were low or very-low quality — the key counter-evidence on certainty

Quelle ansehen

3RCTn=50 · small study2020

About 45% MA peel was found to be equally effective as 30% SA peel in mild-to-moderate facial AV. However, safety and tolerability of MA peel were better than SA peel.

Dayal S, Kalra KD, Sahu P. · J Cosmet Dermatol (2020)

RCT (n=50): 45% mandelic acid vs 30% salicylic acid peels every 2 weeks for six sessions over 12 weeks
Almost equal overall acne improvement; salicylic better on non-inflammatory lesions, mandelic on inflammatory
Fewer adverse effects with the mandelic acid peel — its tolerability advantage

Quelle ansehen

4RCTn=90 · small study2016

GA (35%) and SM acid peels are both equally efficacious and a safe treatment modality for melasma in Indian skin, and are more effective than phytic acid peels. Salicylic-mandelic peels are better tolerated and more suitable for Indian skin.

Sarkar R, Garg V, Bansal S, Sethi S, Gupta C. · Dermatol Surg (2016)

RCT (n=90): glycolic 35% vs salicylic-mandelic vs phytic acid peels for melasma over 12 weeks
MASI reduction ~61% (salicylic-mandelic) vs ~62% (glycolic), no significant difference; both beat phytic acid
Salicylic-mandelic peels better tolerated and judged more suitable for Indian (darker) skin

Quelle ansehen

5RCTn=45 · small study2019

All three chemical peels are effective in the treatment of mild to moderate acne in Asian population. No significant adverse effects were noted.

Sarkar R, Ghunawat S, Garg VK. · J Cutan Aesthet Surg (2019)

RCT (n=45): glycolic vs salicylic-mandelic vs phytic peels biweekly for six sessions
Comparable acne-score reductions (~74% salicylic-mandelic) and significant post-acne pigmentation improvement across groups
No significant adverse effects in this Asian (darker-skin) population

Quelle ansehen

6RCTn=58 · small study2022

Based on MASI and VAS scores, combined treatment was significantly effective than the monotherapy.

Dixit N, Jena A, Panda M, Debasmita B, Ipsita D. · J Cosmet Dermatol (2022)

RCT (n=58) in adult acne: low-dose oral isotretinoin alone vs isotretinoin plus a salicylic-mandelic peel every 4 weeks for 16 weeks
Adding the salicylic-mandelic peel produced significantly greater improvement in acne and scarring scores than isotretinoin alone
Mandelic acid was tested only within a salicylic-mandelic peel, so its independent effect is not isolated

Quelle ansehen

7Open-Labeln=41 · small study2025

The tested cream, which incorporates the ingredients mandelic acid and Centella asiatica, effectively improved participants' skin appearance in adults with sensitive skin and moderate signs of aging.

Widgerow A, Grivet-Seyve M, Anjuwon S, Emesiani C, Meckfessel M. · J Drugs Dermatol (2025)

12-week single-arm open-label study (n=41) of a twice-daily leave-on cream with mandelic acid and Centella asiatica in sensitive aging skin
Significant improvement in crepiness, texture/smoothness, and overall quality with good tolerability
Uncontrolled, multi-ingredient cosmetic — the contribution of mandelic acid alone cannot be isolated (the only leave-on study)

Quelle ansehen

In der Forschungsbibliothek ansehen

Mandelic Acid (topical) – Forschung

Überwiegend Mechanismus / Beobachtung

A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris.

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.

Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris.

Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma.

Comparative Study of 35% Glycolic Acid, 20% Salicylic-10% Mandelic Acid, and Phytic Acid Combination Peels in the Treatment of Active Acne and Postacne Pigmentation.

Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda.

Efficacy and Tolerability of a Cream in Aging Skin.