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Mgs3.0
Mangosteen – Forschung
Überwiegend Mechanismus / Beobachtung
19 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Mangosteen sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 2007–2026 mit einer typischen Studiengröße von 422 Teilnehmenden.
Basierend auf 19 Studien · 11 RCTs · 1,587 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
InflammationEine kleine Pilotstudie fand eine Senkung des C-reaktiven Proteins nur bei der höchsten Saftdosis; eine starke entzündungshemmende Wirkung ist präklinisch · 8 Wochen (hohe Dosis, Pilotdaten)
Zu wenige bewertete Studien1 Studie
Immune supportXanthone modulieren entzündungsfördernde Zytokine in vitro; keine Daten zu immunologischen Endpunkten beim Menschen · Unbekannt
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
10 Studien in den letzten 5 Jahren
200720162026
1RCTn=1,016 · large study2025
Einfach gesagt: Conclusions Adjunctive mangosteen pericarp treatment appeared to have limited efficacy in mood and functional symptoms associated with bipolar disorder, but not with manic symptoms or quality of life, suggesting a novel therapeutic approach that should be verified by replication.
Dean OM, Cotton SM, Ashton MM, Turner A, Saunders L, Ng CH, Hopwood M, Dodd S, Khoo JP, Walker AJ, Chatterton ML, Kavanagh BE, Nadjidai SE, Lo Monaco SL, Harvey BH, Malhi GS, Brown E, Skvarc DR, Diao D, Jacka FN, Sarris J, Dowling NL, Berk M. · The British journal of psychiatry : the journal of mental science (2025)
Results Results indicated limited support for the primary hypothesis of superior depression symptom reduction following 24 weeks of treatment.
These differences were attenuated at week 28 post-discontinuation assessment.
Conclusions Adjunctive mangosteen pericarp treatment appeared to have limited efficacy in mood and functional symptoms associated with bipolar disorder, but not with manic symptoms or quality of life, suggesting a novel therapeutic approach that should be verified by replication.
Einfach gesagt: Larger randomized controlled trials using standardized preparations are required before clinical recommendations can be made.
Purwoko Y, Nugroho KH, Setiati S, Rachmawati B. · Acta medica Indonesiana (2026)
A randomized controlled pilot trial reported significant improvement in insulin sensitivity (HOMA-IR -53.2% vs -15.2%; p = 0.004) after 26 weeks of standardized mangosteen extract.
A small quasi-experimental study reported a significant reduction in FBG following 7 days of mangosteen peel decoction.
However, the conclusions are limited by the small number of available studies, the short follow-up duration in one trial, and variability in extract preparation.
14Übersicht2025
Einfach gesagt: Enhancing extraction procedures, shelf life, and finding new applications in pharmaceuticals and functional foods are all directions in which future investigations need to focus to provide maximum social, economic, and health gains.
Arshad MT, Basher NS, Ibrahim NA, Ikram A, Maqsood S, Rasheed A, Naveed F, Waqar M, Raza A, Noreen S, Al MKM, Ahmad M, Hussain MF, Jebreen A, Al-Farga A. · Food science & nutrition (2025)
This review highlights the numerous uses of these fruits and demonstrates how they can contribute to the areas of sustainable agriculture, medicine, and nutrition.
Perishability, limited cultivation, and underutilized by-products (e.g., peels and seeds) are challenges that persist despite their benefits.
Enhancing postharvest technologies, boosting agronomic practices, and valoring waste would make them more commercially viable.
Einfach gesagt: Further research, especially clinical trials, will be necessary to further impel mangosteen and its derivatives into therapeutic applications.
Thew HY, Tan YC, Ong YS, Goh BH, Khaw KY. · Planta medica (2025)
Anti-inflammatory effects were evident as mangosteen extract reduced pro-inflammatory cytokines and modulated the nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B) and cyclooxygenase-2 (COX-2) pathways in neuroinflammation models.
Xanthones further suppressed inflammatory mediators and enhanced cellular resilience.The in vitro and in vivo results suggested the neuroprotective capabilities of mangosteen extracts and its purified bioactives.
Despite that, gaps remain in understanding the potential synergistic effects of these bioactives, their druggability properties, and clinical applicability.
Einfach gesagt: Because of the insufficient clinical study, we hope the current research can benefit from performing clinical and preclinical studies against different toxic agents.
Yahyazadeh R, Rahimi VB, Yahyazadeh A, Askari VR. · Current neuropharmacology (2024)
Due to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana ( G. mangostana ) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders.
This review presents comprehensive information on Mangosteen's pharmacological and antitoxic aspects and its xanthones against various natural and chemical toxins.
Because of the insufficient clinical study, we hope the current research can benefit from performing clinical and preclinical studies against different toxic agents.
Einfach gesagt: The potential therapeutic applications of α-mangostin as an anti-inflammatory agent warrant further investigation through preclinical and clinical studies to validate its efficacy and safety.
Majdalawieh AF, Khatib BK, Terro TM. · Biomolecules (2025)
Additionally, α-mangostin exhibits immunomodulatory properties by influencing both innate and adaptive immune responses, affecting macrophage polarization, T cell differentiation, and cytokine production.
Its efficacy has been observed in numerous disease models, including joint disorders, digestive and metabolic conditions, hepatic diseases, neurological disorders, and respiratory ailments.
The potential therapeutic applications of α-mangostin as an anti-inflammatory agent warrant further investigation through preclinical and clinical studies to validate its efficacy and safety.
Einfach gesagt: It is also worth considering plant parts other than the pericarp.
Anis Y, Labana RV, Mendonça D, Ayunee S, Dimasin RVD, Bodade R, Sukati S, Boonhok R, Oliveira SMR, Girol AP, de Lourdes Pereira M, Chooi-Ling L, Samudi C, Nissapatorn V. · Tropical biomedicine (2025)
However, other bioactive compounds with potential therapeutic activities remain not fully characterized.
Therefore, developing effective extraction methods for these bioactive compounds, along with their characterization, possible bioactivities (pharmacodynamics), and any synergistic effects, is essential.
Additionally, pharmacokinetic studies, including absorption, distribution, metabolism, excretion, and toxicity (ADMET), are necessary.
Einfach gesagt: Taken together, these data demonstrate that MG attenuates LPS-mediated inflammation in MPhi and insulin resistance in adipocytes, possibly by preventing the activation of MAPK, NF-kappaB, and AP-1, which are central to inflammatory cytokine production in WAT.
Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M · J Nutr (2010)
In-vitro study in cultured human macrophages (U937) and primary human adipocytes
Xanthones reduced TNF-α, IL-6 and IP-10 expression dose-dependently
Attenuated MAPK and AP-1 activation; gamma-mangostin also reduced NF-κB