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Mz4.5
Meso-Zeaxanthin – Forschung
Hilft wahrscheinlich
42 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Meso-Zeaxanthin sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2004–2026 mit einer typischen Studiengröße von 105 Teilnehmenden.
Basierend auf 42 Studien · 3 Meta-Analysen · 25 RCTs · 7,434 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen· 41 weitere ohne bewertete Effektdaten
Nach Outcome
Vision & macular pigmentRaises macular pigment and may improve glare/contrast (surrogate measures); no proven AMD-progression benefit · 3-6 months
Überwiegend Mechanismus / Beobachtung39 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung21 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung7 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung6 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Anxiety & stress
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 15 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
7,434
typische Studie: 105 Personen
Stärkste Designs
28
3 gepoolt, 25 randomisiert
Zeigte Nutzen
100%
1/1 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
3
Untersuchte Populationen
General population3
General population from infancy to old age1
AMD patients and healthy subjects1
General population including pregnant and lactating women1
Aktives Forschungsgebiet
17 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200420152026
1Meta-Analysen=3,159 · very large study2024
Einfach gesagt: All groups significantly increased macular pigment optical density and contrast sensitivity at low spatial frequency, whereas only the antioxidant mixture + lutein (L) + fatty acid combination exhibited significant improvements in visual acuity.
Einfach gesagt: The pooled mean increase in MPOD was 0.04 units (95% CI: 0.02 to 0.07) among studies evaluating 5 to <20 mg/d of lutein/zeaxanthin and was 0.11 units (95% CI: 0.06 to 0.16) among studies evaluating ≥20 mg/d of lutein/zeaxanthin for 3-12 mo.
Einfach gesagt: Retinal carotenoids attenuate A2E formation and can directly and indirectly alleviate A2E-mediated oxidative damage.
Arunkumar R et al. · Advances in experimental medicine and biology (2023)
The pyridinium bisretinoid, N-retinylidene-N-retinylethanolamine (A2E), contributes to drusen formation in dry age-related macular degeneration (AMD) and to the autofluorescent flecks in autosomal recessive Stargardt disease (STGD1).
Retinal carotenoids attenuate A2E formation and can directly and indirectly alleviate A2E-mediated oxidative damage.
In this chapter, we review these more recently recognized interconnections between MP carotenoids and A2E bisretinoids.
Einfach gesagt: The data suggest that carotenoid vitamin therapy exerts synergic neuroprotective benefits and has the capacity to serve adjunctive therapy in the management of glaucoma.
Lem DW et al. · Nutrients (2021)
A comprehensive literature search was conducted in three databases (PubMed, Cochrane Library, and Web of Science) and 20 records were identified for screening.
Lutein demonstrated enhanced neuroprotection on retinal ganglion cell survival and preserved synaptic activity.
In clinical studies, a protective trend was seen with greater dietary consumption of carotenoids and risk of glaucoma, while greater carotenoid levels in macular pigment were largely associated with improved visual performance in glaucomatous eyes.
Einfach gesagt: The diet supplements of L + Z or L + Z+MZ are associated with better cognitive functioning, which may be via their beneficial effects on the vision.
Wang H et al. · Journal of Alzheimer's disease : JAD (2022)
The diet supplements of L + Z or L + Z+MZ are associated with better cognitive functioning, which may be via their beneficial effects on the vision.
Einfach gesagt: These findings provide a strong molecular basis and a line of evidence that suggests carotenoid vitamin therapy may offer enhanced neuroprotective effects with therapeutic potential to function as an adjunct nutraceutical strategy for management of diabetic retinopathy.
Lem DW et al. · Nutrients (2021)
Lutein and zeaxanthin demonstrated significant protection against capillary cell degeneration and hyperglycemia-induced changes in retinal vasculature.
Observational studies indicate that depletion of xanthophyll carotenoids in the macula may represent a novel feature of DR, specifically in patients with type 2 or poorly managed type 1 diabetes.
Meanwhile, early interventional trials with dietary carotenoid supplementation show promise in improving their levels in serum and macular pigments concomitant with benefits in visual performance.
Einfach gesagt: Next, we turn to clinical evidence supporting functional benefits of these carotenoids in normal eyes and for their potential protective actions against ocular disease from infancy to old age.
Bernstein PS et al. · Progress in retinal and eye research (2016)
Next, we turn to clinical evidence supporting functional benefits of these carotenoids in normal eyes and for their potential protective actions against ocular disease from infancy to old age.
9Macular pigment optical density increaseMeta-Analyse2016
Einfach gesagt: This meta-analysis revealed that lutein, zeaxanthin and meso-zeaxanthin supplementation improved MPOD both in AMD patients and healthy subjects with a dose-response relationship.
Ma L et al. · Nutrients (2016)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Xanthophyll carotenoids supplementation was associated with significant increase in MPOD in AMD patients (WMD, 0.07; 95% CI, 0.03 to 0.11) and healthy subjects (WMD, 0.09; 95% CI, 0.05 to 0.14).
Additionally, the changes in MPOD were related with baseline MPOD levels (rAMD = -0.43, p = 0.06; rhealthy subjects = -0.71, p < 0.001) and blood xanthophyll carotenoids concentration (rAMD = 0.40, p = 0.07; rhealthy subjects = 0.33, p = 0.05).
Stratified analysis showed a greater increase in MPOD among trials supplemented and combined with meso-zeaxanthin.
Einfach gesagt: The MP carotenoids filter high-intensity, short-wavelength visible light and are powerful antioxidants in a region vulnerable to light-induced oxidative stress.
Arunkumar R et al. · Biochimica et biophysica acta. Molecular and cell biology of lipids (2020)
The MP carotenoids filter high-intensity, short-wavelength visible light and are powerful antioxidants in a region vulnerable to light-induced oxidative stress.
This review focuses on MP chemistry, absorption, metabolism, transport, and distribution with special emphasis on animal models used for MP study.
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro.
Einfach gesagt: Accumulating evidence about variable interindividual response to dietary intake of these carotenoids, based on genetic or metabolic influences, suggests that there may be subgroups that benefit from higher levels of intake and/or alternate strategies to improve lutein and zeaxanthin status.
Mares J · Annual review of nutrition (2016)
Additionally, egg yolks and human milk appear to be bioavailable sources.
The prevalence of lutein, zeaxanthin, and meso-zeaxanthin in supplements is increasing.
Setting optimal and safe ranges of intake requires additional research, particularly in pregnant and lactating women.
Einfach gesagt: The question of an optimal dietary antioxidant supply is evaluated in the context of the dual roles of both oxidants and antioxidants, in all vital functions of living organisms, and the profound impact of individual and environmental context.
Demmig-Adams B et al. · Molecules (Basel, Switzerland) (2020)
This review compares and contrasts the role of carotenoids across the taxa of life-with a focus on the xanthophyll zeaxanthin (and its structural isomer lutein) in plants and humans.
Xanthophylls' multiple protective roles are summarized, with attention to the similarities and differences in the roles of zeaxanthin and lutein in plants versus animals, as well as the role of meso-zeaxanthin in humans.
Detail is provided on the unique control of zeaxanthin function in photosynthesis, that results in its limited availability in leafy vegetables and the human diet.
Einfach gesagt: In this review, we discuss how the differences in the specific properties of lutein and zeaxanthin could help explain the preferential accumulation of zeaxanthin in the most vulnerable region of the macula.
Widomska J et al. · Nutrients (2020)
Zeaxanthin concentrations are 2.5-fold higher than lutein in the cone-dense central fovea.
This is an ~20-fold increase in the molar ratio relative to eccentric retinal regions with biochemically detectable macular xanthophylls.
The distribution of diet-based macular xanthophylls and the lutein metabolite meso-zeaxanthin varies considerably by retinal eccentricity.
16Macular pigment optical densityRCTn=105 · medium study2024
Einfach gesagt: This RCT provides direct evidence for the efficacy of meso-zeaxanthin-containing supplements on macular pigment and vision in healthy adults, extending the evidence base beyond AMD populations.
Nolan JM et al. · Nutrients (2024)
Macular pigment optical density increased significantly with meso-zeaxanthin, lutein, and zeaxanthin supplementation vs. placebo
Visual performance measures including contrast sensitivity showed meaningful improvement in the supplemented group
The supplement combination was well tolerated with no serious adverse events reported
Einfach gesagt: This 24-month RCT provides direct clinical evidence for meso-zeaxanthin combined carotenoid supplementation improving both macular pigment and visual function in intermediate AMD patients.
Nolan JM et al. · Nutrients (2023)
Significant increases in macular pigment optical density were observed in the supplemented group versus placebo at 24 months
Visual function measures including contrast sensitivity and glare disability improved in the supplemented group
Supplement was well tolerated with no serious adverse events attributed to treatment