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Mo3.5
Molybdenum – Forschung
Hilft wahrscheinlich
27 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Molybdenum half in etwa der Hälfte (2/3) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1993–2026 mit einer typischen Studiengröße von 400 Teilnehmenden.
Basierend auf 27 Studien · 4 Meta-Analysen · 5 RCTs · 141,373 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen1unklar· 24 weitere ohne bewertete Effektdaten
Nach Outcome
Micronutrient & trace-element status
Überwiegend Mechanismus / Beobachtung12 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung9 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung4 Studien
Cholesterol & lipids
Zu wenige bewertete Studien2 Studien
Women's health
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 14 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
141k
typische Studie: 400 Personen
Stärkste Designs
9
4 gepoolt, 5 randomisiert
Zeigte Nutzen
67%
2/3 Studien
Wie lange Studien liefen
3+ Monate
1
Untersuchte Populationen
General population2
Bariatric surgery patients1
pregnant women1
Systemic lupus erythematosus patients1
Aktives Forschungsgebiet
20 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2023
199320092026
1Mineral deficiency rates after bariatric surgeryMeta-AnalyseCited 10×n=47,432 · very large study2023
A high deficiency rate of serum iron, zinc, copper, chlorine, phosphorus, and calcium was seen after bariatric surgery.
Cao L et al. · Obesity surgery (2023)
Groß Nutzen
← SchlechterKein EffektBesser →
The most severe mineral deficiency after bariatric surgery was iron (20.1%), followed by zinc (18.3%), copper (14.4%), chlorine (12.2%), phosphorus (7.5%), and calcium (7.4%).
The difference in surgical procedures, study regions, and follow-up time may affect postoperative mineral status; more targeted mineral supplement programs are needed considering these influencing factors.
2Hyperuricemia riskMeta-AnalyseCited 18×n=63,283 · very large study2022
Gu T et al. · Clinical rheumatology (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Data were pooled by random-effects models and expressed as pooled odds ratios (OR) and 95% confidence intervals (CIs).
Exposure to molybdenum (pooled OR = 0.804, 0.724, 0.975, 3, 0%) was linked to a decreased risk of HUA, however.
Molybdenum exposure was associated with a decreased prevalence of HUA; however, aluminum, cobalt, copper, iron, magnesium, manganese, mercury, selenium, thallium and zinc are not associated with HUA risk.
Shiani A et al. · Biological trace element research (2024)
Based on the findings, it is acceptable to infer that maternal exposure to toxic elements, whether through environmental contaminants or dietary sources, was associated with an elevated risk of OFCs.
Furthermore, the study revealed that ETEs exhibited a potential protective role in reducing the incidence of OFCs.
This observation highlights the importance of reducing exposure to toxic elements during pregnancy and suggests that optimizing maternal intake of ETEs could be an effective preventive strategy.
The results of this study showed that the concentration of nutrients in most articles was undesirable.
Aghalari Z et al. · Journal of health, population, and nutrition (2022)
The results of this study showed that the concentration of nutrients in most articles was undesirable.
It is suggested that optimal methods of enrichment of breads and flours be done with interdisciplinary cooperation between food hygiene, environmental health, nutrition, farmers and bakers.
It is recommended that food hygiene and environmental health researchers investigate other nutrients (including phosphorus, selenium, manganese, boron and molybdenum) in breads and other staple foods used by people to constructive and practical measures to increase public health.
However, it can be assumed that altered concentrations of those elements are crucial regarding the onset and exaggeration of either psychotic or negative symptoms or cognitive dysfunctions.
Baj J et al. · International journal of molecular sciences (2020)
This review includes the analysis of serum levels of the following trace elements: iron, nickel, molybdenum, phosphorus, lead, chromium, antimony, uranium, magnesium, aluminum, zinc, copper, selenium, calcium, and manganese.
Currently, there is no consistency regarding serum trace element levels in schizophrenic patients.
Thus, it cannot be considered as a reliable prognostic or diagnostic marker of schizophrenia.
In addition, the report describes the main mechanisms by which metals exert their toxic effects on the body, as well as the primary sources of pollution through which they are released into the environment.
Rojas-Lemus M, López-Valdez N, González-Villalva A, Bizarro-Nevares P, Casarrubias-Tabarez B, Cervantes-Valencia ME, Ustarroz-Cano M, Rivera-Fernández N, Anacleto-Santos J, Chávez-Maya F, Milán-Chávez R, Morales-López S, Fortoul TI. · International journal of molecular sciences (2026)
However, when the organism is overexposed, those same essential metals-in high concentrations that become toxic-cause imbalances or overt pathologies.
On the other hand, there are metals that are not essential in humans, so their presence and accumulation in the organism can cause adverse effects.
In this review we focus on the essentiality and toxicity of the main trace metals such as iron, zinc, copper, manganese, chromium, cobalt, molybdenum, and nickel, as well as on the toxicity of metals such as vanadium, cadmium, and lead that are not essential for humans.
Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Lan L et al. · Journal of cellular and molecular medicine (2024)
Trace elements are minimal yet essential components of human body that cannot be overlooked, and they participate in enzyme activation, DNA synthesis, antioxidant defence, hormone production, etc.
Moreover, trace elements are particularly involved in immune regulations.
Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
9molybdenum role in gestational complicationsSystematische Übersicht2023
This review summarises the current literature concerning varied recommendations on molybdenum intake, the role of molybdenum and molybdoenzymes in physiology, and the contribution these play in gestational outcomes.
Foteva V et al. · Nutrients (2023)
Overexposure and deficiency can result in adverse health outcomes and mortality, although physiological doses remain largely unexplored in relation to human health.
The lack of knowledge surrounding molybdenum intake and the role it plays in physiology is compounded during pregnancy.
As pregnancy progresses, micronutrient demand increases, and diet is an established factor in programming gestational outcomes and maternal health.
The current review provides an updated discussion of the plausible mechanisms combining Cu, S, and Mo alterations in AD.
Coelho FC et al. · International journal of molecular sciences (2022)
Alzheimer's disease (AD) and other forms of dementia was ranked 3rd in both the Americas and Europe in 2019 in a World Health Organization (WHO) publication listing the leading causes of death and disability worldwide.
The current review provides an updated discussion of the plausible mechanisms combining Cu, S, and Mo alterations in AD.
11Cancer prevention and treatmentMeta-AnalyseCited 69×2006
The systematic review of the literature does not support the hypothesis that the use of supplements of vitamin C or vitamin E in the doses tested helps prevent and/or treat cancer in the populations tested.
Coulter ID et al. · Journal of general internal medicine (2006)
The systematic review of the literature does not support the hypothesis that the use of supplements of vitamin C or vitamin E in the doses tested helps prevent and/or treat cancer in the populations tested.
There were isolated findings of benefit, which require confirmation.
This study also highlights the potential of crop biofortification as a sustainable, strategy to enhance the nutrient density of vegetables within controlled dietary patterns.
Baldassano S et al. · Nutrients (2025)
Dietary intake was carefully monitored throughout the 12-day period to control for confounding dietary effects.
Results: The intervention was associated with decreased plasma levels of triglycerides, AST, and ALT, and increased plasma levels of HDL-cholesterol and the satiety hormone PYY, suggesting enhanced metabolic regulation.
Conclusions: These biochemical markers reflect early metabolic adaptations that may inform future research on the metabolic impact of micronutrient biofortification.
14Lung cancer mortalityRCTCited 39×n=147 · medium study2006
Supplementation with combinations of vitamins and minerals at nutrient-repletion levels for 5.25 years did not reduce lung cancer mortality in this nutrient-inadequate population in Linxian, China.
Kamangar F et al. · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2006)
Lung cancer deaths (n = 147) identified during the trial period (1986-1991) and 10 years after the trial ended (1991-2001) were the study outcome.
No significant differences in lung cancer death rates were found for any of the four combinations of supplements tested in this study, using log-rank tests (all P values are >0.20) or Cox proportional hazards models adjusted for age, sex, commune, and other treatments.
No significant interactions were seen for age, sex, or smoking status.
15Cancer and total mortalityRCTCited 44×n=29,584 · very large study2018
Multiyear nutrition intervention is unlikely to have a meaningful effect on mortality more than a decade after supplementation ends, even in a nutritionally deprived population.
Wang SM et al. · Journal of the National Cancer Institute (2018)
Kein klarer Effekt
← SchlechterKein EffektBesser →
The protective effect of Factor D for gastric cancer was attenuated (HR = 0.93, 95% CI = 0.85 to 1.01), but a newly apparent protective effect against esophageal cancer was found for Factor B (HR = 0.92, 95% CI = 0.85 to 1.00, two-sided P = .04).
Protective effects were found in people younger than age 55 years at baseline against non-upper gastrointestinal cancer death for Factor A (HR = 0.80, 95% CI = 0.69 to 0.92) and against death from stroke for Factor C (HR = 0.89, 95% CI = 0.82 to 0.96).
In contrast, increased risk of esophageal cancer was found when the intervention began after age 55 years for Factors C (HR = 1.16, 95% CI = 1.04 to 1.30) and D (HR = 1.20, 95% CI = 1.07 to 1.34).
At present, available evidence does not support routine assessment of trace element status or generalized supplementation in the prevention or management of allergic diseases, except in cases of documented deficiency or clearly defined clinical indications.
Ordak M, Zemelka-Wiacek M, Kosowska A, Jutel M, Anna K, Michal M, Hubert P, Pawlasek J, Bulska E, Ruszczynska A, Konieczynski P, Wesolowski M, Plenis A, Sousa-Pinto B, Bognanni A, Martini M, Paoletti G, di Bona D, Canonica GW, Bousquet J, Feleszko W, Cieslik M, Leung CWM, Leung TF, Eljaszewicz A. · Allergy (2026)
However, reported associations between elemental status and allergic diseases remain heterogeneous across studies.
This variability likely reflects both underlying biological differences and methodological heterogeneity, including variation in study design, biological matrices, exposure assessment, and analytical techniques.
Better methodological harmonization will be essential to elucidate the roles of trace elements in allergy development and to strengthen future translational and preventive research efforts.
This systematic-review examined the effects of Molybdenum.
· Unknown Journal (2025)
Systematic review examining Molybdenum efficacy
Published in Unknown Journal (2025)
Further research warranted to confirm findings
18Systematische Übersicht2025
This will allow for the assessment of the clinical usefulness of supplementation or dietary enrichment as an adjunctive therapeutic approach in the treatment of EM symptoms.
Pokorska-Niewiada K, Ziętek M, Szydłowska I, Ryterska K, Szczuko M. · Antioxidants (Basel, Switzerland) (2025)
Most studies showed decreased zinc levels in women with EM, and copper and molybdenum were usually in comparable amounts, whereas the results for selenium are inconclusive.
The lack of direct clinical trials of antioxidant element supplementation, coupled with evidence of differences in their levels between women with EM and healthy women, warrants further, more detailed analysis.
Studies should be expanded to include dose-response analyses and potential threshold effects.
19Molybdenum-copper antagonism in metalloproteinsSystematische Übersicht2024
Therefore, this review aims to connect the Mo-Cu antagonism in metalloproteins and anti-copper therapy.
Maiti BK et al. · Chembiochem : a European journal of chemical biology (2024)
However, this interaction was first observed in ruminants, and they convert molybdate (MoO4 2- ) into tetrathiomolybdate (MoS4 2- ; TTM), reacting with cellular Cu to yield biological unavailable Mo/S/Cu cluster, then developing Cu-deficiency diseases.
These findings inspire the use of TTM as a Cu-sequester drug, especially for treating Cu-dependent human diseases such as Wilson diseases (WD) and cancer.
It is well known that a balanced Cu homeostasis is essential for a wide range of biological processes, but negative consequence leads to cell toxicity.
20Molybdenum enzyme function in redox reactionsSystematische Übersicht2024
Further research into the molecular mechanisms underlying these enzymes' functions could lead to novel treatments and improved patient outcomes.
Adamus JP et al. · Biomolecules (2024)
The newest member of molybdenum-containing enzymes is mitochondrial amidoxime-reducing component (mARC), involved in drug metabolism and detoxification reactions.
Emerging evidence suggests its involvement in liver pathologies such as HCC and NAFLD, indicating its potential as a therapeutic target.
Overall, understanding the roles of molybdenum-containing enzymes in human physiology and disease pathology is essential for advancing diagnostic and therapeutic strategies for various health conditions, particularly those related to liver dysfunction.