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Msm6.0
MSM – Forschung
Hilft vermutlich
23 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu MSM sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2025 mit einer typischen Studiengröße von 88 Teilnehmenden.
Basierend auf 23 Studien · 2 Meta-Analysen · 16 RCTs · 11,298 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen· 21 weitere ohne bewertete Effektdaten
Nach Outcome
Joint pain & arthritisVerringert Arthroseschmerzen und verbessert die körperliche Funktion · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung23 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
RecoveryReduzierter Muskelkater nach dem Training · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
InflammationReduzierte Gelenkschmerzen und Steifheit · 4-12 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Skin healthSchwefeldonor unterstützt die Kollagen- und Keratinsynthese · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Cholesterol & lipids
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Endurance & exercise performance
Zu wenige bewertete Studien1 Studie
Therapeutic & clinical
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
Immune support
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 15 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
83%
über Studien hinweg
Untersuchte Personen
11k
typische Studie: 88 Personen
Stärkste Designs
18
2 gepoolt, 16 randomisiert
Zeigte Nutzen
100%
2/2 Studien
Wie lange Studien liefen
1–3 Monate
3
3+ Monate
2
Untersuchte Populationen
Patients with osteoarthritis1
Osteoarthritis patients1
Chronic bacterial prostatitis patients1
Healthy participants with mild knee pain1
Aktives Forschungsgebiet
15 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200620152025
1WOMAC pain score improvementMeta-AnalyseCited 3×n=2,455 · very large study2025
Passion fruit peel extract was the best supplement for improving WOMAC pain and function scores in patients with osteoarthritis, followed by Lanconone and collagen.
Chen CS et al. · Journal of integrative medicine (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
In the WOMAC pain score, the SUCRA of passion fruit peel extract was 91% (mean difference [MD]: -9.2; 95% confidence interval [CI]: [-16.0, -2.3]), followed by methylsulfonylmethane (89%), undenatured type II collagen (87%), collagen (84%), and Lanconone (82%).
The SUCRA (99%) of passion fruit peel extract (MD: -41.0; 95% CI: [-66.0, -16.0]) ranked first in terms of the WOMAC function score, followed by Lanconone (95%), collagen (86%), ParActin (84%), and Lactobacillus casei strain Shirota (83%).
The top three total rankings are passion fruit peel extract (95.0%), Lanconone (88.5%), and collagen (85.0%).
The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low.
Liu X et al. · British journal of sports medicine (2018)
Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and chondroitin) revealed statistically significant improvements on pain, but were of unclear clinical importance.
Chondroitin demonstrated statistically significant, but not clinically important structural improvement (effect size -0.30, -0.42 to -0.17).
The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low.
3Pain outcomes in osteoarthritis treatmentSystematische ÜbersichtCited 58×n=681 · large study2008
No definitive conclusion can currently be drawn for either supplement.
Brien S et al. · Osteoarthritis and cartilage (2008)
Two of the four DMSO trials, and both MSM trials reported significant improvement in pain outcomes in the treatment group compared to comparator treatments, however, methodological issues and concerns over optimal dosage and treatment period, were highlighted.
No definitive conclusion can currently be drawn for either supplement.
The findings from all the DMSO studies need to be viewed with caution because of poor methodology including; possible unblinding, and questionable treatment duration and dose.
The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its molecular mechanisms of actions and data of efficacy and safety (when available).
Colletti A et al. · International journal of molecular sciences (2021)
It is characterized by pain, stiffness, and a reduced range of motion with regard to the arthritic joints.
These symptoms can cause in the long term a greater risk of overweight/obesity, diabetes mellitus, and falls and fractures.
The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its molecular mechanisms of actions and data of efficacy and safety (when available).
5Clinical efficacy in chronic bacterial prostatitisRCTCited 14×n=2,015 · very large study2016
The combination of serenoa repens, selenium, lycopene + bromelain and methylsulfonylmethane extracts improved the clinical efficacy of levofloxacin in patients affected by CBP without the development of side effects.
Cai T et al. · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica (2016)
Likely real
At the second follow-up visit (T2), questionnaire results demonstrated statistically significant differences between groups (p < 0.001).
One patient in Group A (2.5%) and 7 patients (17.9%) in Group B showed a symptomatic and microbiological recurrence (p = 0.02).
The combination of serenoa repens, selenium, lycopene + bromelain and methylsulfonylmethane extracts improved the clinical efficacy of levofloxacin in patients affected by CBP without the development of side effects.
6Knee quality of life scoresRCTCited 9×n=88 · small study2023
This study indicated that MSM oral consumption improved both knee and systemic health conditions in healthy participants who experienced mild pain in the knee joint.
Toguchi A et al. · Nutrients (2023)
Likely real
The total scores at 12 weeks in the MSM and placebo groups as the primary outcome were significantly different (p = 0.046).
The health condition of JKOM also improved after MSM consumption (p = 0.032).
The questionnaire results also suggested improvement in the knee and systemic health.
combination of glucosamine-chondroitinsulfate-methylsulfonylmethane showed clinical benefit for patients with knee OAK ellgren-Lawrence grade I-II compared with GC and placebo.
Lubis AMT et al. · Acta medica Indonesiana (2017)
Likely real
on statistical analysis it was found that at the 12th week, there are significant difference between three treatment groups on the WOMAC score (p=0.03) and on the VAS score (p=0.004).
When analyzed between weeks, GCM treatment group was found statistically significant on WOMAC score (p=0.01) and VAS score (p<0.001).
Comparing the score difference between weeks, WOMAC score analysis showed significant difference between GC, GCM, and placebo in week 4 (p=0.049) and week 12 (p=0.01).
8RCTn=49 · small study2020
This study provides recent evidence for MSM's role in exercise recovery and muscle soreness reduction.
Withee ED et al. · Journal of the International Society of Sports Nutrition (2020)
MSM supplementation significantly reduced muscle soreness following exercise
Improved markers of antioxidant status compared to placebo group
No significant effects on exercise performance parameters
10Hand pain in symptomatic hand osteoarthritisRCTCited 19×n=106 · medium study2021
There were no significant differences in symptomatic relief between the two groups over 12 weeks.
Liu X et al. · Osteoarthritis and cartilage (2021)
One hundred and six participants were included with mean age 65.6 years and 81% were women. 45% of the participants were graded as KLG 4, 40% KLG three and 39 (37%) had erosive OA.
The adjusted between group difference in means (95%CI) was 5.34 (-2.39 to 13.07).
Five participants (10%) in the supplement combination group discontinued study treatment due to AE vs four participants (7%) in the placebo group.
Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol.
Miller L et al. · Nutrients (2021)
The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013).
Measurements occurred at baseline and after 4, 8, and 16 weeks.
Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status.
Future research should seek to validate how the changes observed with exercise may model to various chronic inflammatory states.
McFarlin BK et al. · Nutrients (2025)
Results: This study is the first to demonstrate significant effects with lower MSM doses (0.5-1.0 g/d) compared to previous work using higher doses (3 g/d).
We identified 29 mRNAs in four distinct immune response pathways (peripheral tissue inflammatory response, myeloid immune cell invasion, NK cell invasion/activity, and notch signaling) whose response was statistically changed with MSM at 2 h and/or 4 h.
Future research should seek to validate how the changes observed with exercise may model to various chronic inflammatory states.
16Systematische Übersichtn=5,265 · very large study2024
Conclusions: For KOA, combining glucosamine with omega-3 and ibuprofen effectively reduces pain and may lower NSAID side effects, improving treatment guidelines and decision-making for better patient care.
Sumsuzzman DM, Khan ZA, Jung JH, Hong Y, Yang WJ, Park K, Choi HJ, Jeong OC, Kim SJ, Hong Y. · Journal of clinical medicine (2024)
Methods: Frequentist random-effects models were employed for this NMA, with standardized mean differences (SMDs) and 95% confidence intervals (CIs) calculated for primary outcomes.
We incorporated an SMD value of 0.40 as a minimum clinically important difference (MCID) to interpret the pain outcome.
Glucosamine with omega-3 (G + omega-3, SMD -2.59 [95% CI -4.42 to -0.75], moderate quality) and glucosamine with ibuprofen (G + ibuprofen, SMD -2.27 [95% CI -3.73 to -0.82], moderate quality) significantly reduced overall pain compared to placebo.
The combination of CS/GL/MSM/HA with collagen significantly outperforms collagen-free therapy in reducing pain, improving joint function, and decreasing symptomatic treatment needs in patients with knee OA exacerbations.
Naumov AV et al. · Terapevticheskii arkhiv (2025)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Group B demonstrated significant superiority: a 76% reduction in WOMAC pain scores (vs. 47% in Group A; p=0.04) and a 74% reduction in VAS scores (vs. 56%; p<0.05).
NSAID use at week 8 was 2.6±0.5 days in Group B (vs. 4.3±1.8 in Group A; p=0.04).
Functional improvements (12% increase in walking speed, 42% reduction in Timed Up-and-Go test duration) were also more pronounced in Group B (p<0.05).
19O'leary plaque index, gingival index and sulcus bleeding indexBeobachtungsstudie2024
According to our findings which showed the similar efficiency of novel chewing gum and chlorhexidine mouthwash in improving and reducing plaque and gingival indexes, we can conclude that novel chewing gum can be introduced as an effective, cheap and accessible tool for dental plaque control.
Shakhsi Niaee M, Hedayatipanah M, Torkzaban P, Mohammadi T. · Scientific reports (2024)
Borderline
Paired sample t test revealed that there were significant differences between first and second period for O'leary plaque index, gingival index and sulcus bleeding index in Group1 (P < 0.05).
But in Group2 there were no differences between first and second period for all indexes.
According to regression model results, type of treatment had no effect on mean of all indexes.
Randomized, double-blind studies are warranted to confirm the effectiveness of this dietary supplement.
Desideri I et al. · Medical oncology (Northwood, London, England) (2022)
Aromatase Inhibitors (AIs) are recommended for the adjuvant treatment of hormone receptor positive breast cancer in both high-risk pre-menopausal and post-menopausal population; arthralgia is the main cause of discontinuation of therapy and affects up to 25% of population on AI treatment.
Seven subjects (13.2%) were not included in the final analysis because of consent withdrawal. 46 participants were eligible for final analysis.
According to CTCAE scale, 10 out of 46 patients reported symptoms resolution at 6-month follow-up from the time of enrollment T0 (p = 0.0009).