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MVI6.0
Multivitamin – Forschung
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74 begutachtete Studien
Was die Evidenz sagt
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Multivitamin half in etwa der Hälfte (8/13) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2003–2026 mit einer typischen Studiengröße von 603 Teilnehmenden.
Basierend auf 74 Studien · 18 Meta-Analysen · 33 RCTs · 68,222 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
8geholfen4unklar1nicht geholfen· 61 weitere ohne bewertete Effektdaten
Nach Outcome
Cognitive functionVerbesserte Gedächtnisleistung bei älteren Erwachsenen, insbesondere des episodischen Gedächtnisses · 3-6 Monate
Hilft vermutlich41 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung21 Studien
Micronutrient & trace-element status
Hilft vermutlich21 Studien
Women's health
Überwiegend Mechanismus / Beobachtung13 Studien
Heart & blood pressureModerater kardiovaskulärer Nutzen vorrangig bei Personen mit Ernährungslücken; kein starker Primärpräventionseffekt bei gut ernährten Bevölkerungsgruppen · 3-12 Monate
Hilft vermutlich12 Studien
Immune supportVerringerte Häufigkeit und Dauer häufiger Infektionen; verbesserte Funktion der Immunzellen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung7 Studien
Longevity & agingMögliche Verringerung der Krebsinzidenz bei Männern; antioxidative Unterstützung bei der Zellalterung · 6-24 Monate
Überwiegend Mechanismus / Beobachtung6 Studien
Anxiety & stressB-Komplex-Vitamine und Magnesium können empfundenen Stress und Angst verringern · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Vision & eye healthVerringertes Risiko für altersbedingte Katarakte und Makuladegeneration bei bestimmten Formulierungen (AREDS-Typ) · 6-24 Monate
Zu wenige bewertete Studien2 Studien
Bone healthUnterstützt die Knochenmineraldichte und Skelettfestigkeit · 8-12 Wochen
Zu wenige bewertete Studien2 Studien
Recovery
Zu wenige bewertete Studien2 Studien
Depression & moodModerate Verringerung von Stress und Stimmungsstörungen im Zusammenhang mit der Auffüllung von B-Komplex und Magnesium · 4-8 Wochen
Zu wenige bewertete Studien1 Studie
Energy & fatigueVerringerung der Müdigkeit im Zusammenhang mit unzureichender Versorgung mit B-Vitaminen und Eisen · 2-6 Wochen
2Global cognitionMeta-AnalyseCited 25×n=5,765 · very large study2024
Multivitamin-mineral supplementation showed a beneficial effect on global cognition compared with placebo, with the pooled analysis across COSMOS cognitive studies estimating a treatment benefit equivalent to 2.0 years of age-related cognitive decline.
Vyas CM et al. · The American Journal of Clinical Nutrition (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Multivitamin-mineral supplementation significantly improved global cognition vs placebo (pooled meta-analysis)
Treatment benefit estimated at equivalent of 2.0 years of age-related cognitive decline
Episodic memory was particularly improved in the clinic subcohort
Extended follow-up from one of the largest RCTs on multivitamins and cognition, reinforcing the potential for multivitamins to protect against age-related cognitive decline.
Baker LD et al. · Alzheimer's & Dementia (2024)
Daily multivitamin supplementation slowed global cognitive decline by the equivalent of ~2 years over 3 years
Benefits were more pronounced in participants with cardiovascular disease history
Memory and executive function domains showed the strongest protective effects
The topic of this review is the impact of bariatric surgery procedures on vitamin and mineral absorption and the role of dietary supplements in maintaining a healthy nutritional balance during the postoperative phase.
Gasmi A et al. · Critical reviews in food science and nutrition (2023)
Therefore, adequate multivitamin and mineral supplements become essential to prevent/overcome micronutrient deficiencies.
Bariatric surgery also raises the risk of small for gestational age (SGA) babies.
Hence, a 12 - 24 months gap is recommended between bariatric surgery and pregnancy to achieve desired weight loss targets.
8Progression to late age-related macular degenerationSystematische Übersichtn=2,445 · very large study2023
Moderate-certainty evidence suggests that antioxidant vitamin and mineral supplementation (AREDS: vitamin C, E, beta-carotene, and zinc) probably slows down progression to late AMD.
Evans JR et al. · The Cochrane database of systematic reviews (2023)
Groß Nutzen
← SchlechterKein EffektBesser →
These studies enroled 11,952 people aged 65 to 75 years and included slightly more women (on average 56% women).
People taking antioxidant vitamins were less likely to progress to late AMD (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.58 to 0.90; 3 studies, 2445 participants; moderate-certainty evidence).
Low-certainty evidence from one study of 110 people suggested higher quality of life scores (measured with the Visual Function Questionnaire) in treated compared with non-treated people after 24 months (mean difference (MD) 12.30, 95% CI 4.24 to 20.36).
Evidence was insufficient to recommend multivitamin/mineral supplements for the prevention of cardiovascular disease or cancer in the general adult population.
Fortmann SP et al. · Annals of internal medicine (2013)
Evidence was insufficient to recommend multivitamin/mineral supplements for the prevention of cardiovascular disease or cancer in the general adult population.
No consistent benefit was found across the included trials.
Evidence was insufficient to prove or disprove that multivitamin/mineral supplements prevent cancer or chronic disease in adults without known nutritional deficiencies.
Huang HY et al. · Annals of internal medicine (2006)
Evidence was insufficient to prove or disprove that multivitamin/mineral supplements prevent cancer or chronic disease in adults without known nutritional deficiencies.
13HIV disease progression and mortalityRCTCited 261×n=1,078 · large study2004
Multivitamin supplementation (B vitamins, C, and E) significantly reduced disease progression and mortality in HIV-infected adults not yet on antiretroviral therapy.
Fawzi WW et al. · The New England journal of medicine (2004)
Multivitamin supplementation (B vitamins, C, and E) significantly reduced disease progression and mortality in HIV-infected adults not yet on antiretroviral therapy.
Supplementation also improved CD4 cell counts and reduced viral load.
14Cancer recurrence riskRCTCited 166×n=1,134 · large study2020
Use of antioxidant supplements (vitamins C and E, carotenoids, coenzyme Q10) during chemotherapy was associated with increased risk of recurrence and mortality in breast cancer patients.
Ambrosone CB et al. · Journal of Clinical Oncology (2020)
Groß Schaden
← SchlechterKein EffektBesser →
Antioxidant vitamin supplementation during chemotherapy was associated with higher recurrence risk (HR 1.41)
All-cause mortality was higher in antioxidant supplement users during chemotherapy
Vitamin B12 supplement use was also associated with increased recurrence risk
15Global cognition scoresRCTn=2,262 · very large study2024
Provides compelling long-term RCT evidence that daily multivitamin use meaningfully slows cognitive aging in older adults, a key finding for the cognition and longevity categories.
Baker et al. · Alzheimer's & Dementia (2024)
Daily multivitamin supplementation significantly improved global cognition scores versus placebo over 3 years
Episodic memory showed the most consistent benefit, particularly in participants with cardiovascular disease history
The cognitive benefit was estimated to be equivalent to slowing approximately 2 years of age-related cognitive decline
Periconceptional multivitamin supplementation was associated with significant reductions in neural tube defects, cardiovascular defects, urinary tract defects, and limb defects.
Ingrid Goh Y et al. · Journal of Obstetrics and Gynaecology Canada (2006)
Groß Nutzen
← SchlechterKein EffektBesser →
Periconceptional MVI use significantly reduced risk of neural tube defects (OR 0.67)
Significant reduction in congenital cardiovascular defects (OR 0.78)
Urinary tract anomalies reduced by 46% with MVI supplementation
20Incident clinical fractureRCTCited 3×n=442 · medium study2025
Forty percent of older US adults take multivitamin/multimineral (MVM) supplementation.
Crandall CJ et al. · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Forty percent of older US adults take multivitamin/multimineral (MVM) supplementation.
Compared with placebo, cocoa extract was not significantly associated with lower risk of incident clinical fracture (adjusted hazard ratio [aHR] 1.03, 95% CI 0.95-1.12) or nonvertebral fracture (aHR 1.05, 95% CI 0.96-1.14).
MVM supplementation was not associated with lower risk of total clinical fracture (aHR 1.09, 95% CI 1.00-1.19), hip fracture (aHR 1.06, 95% CI 0.80-1.42), or nonvertebral fracture (aHR 1.10, 95% CI 1.00-1.20).