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Nia6.0
Niacinamide – Forschung
Überwiegend Mechanismus / Beobachtung
23 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Niacinamide sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1993–2026 mit einer typischen Studiengröße von 76 Teilnehmenden.
Basierend auf 23 Studien · 1 Meta-Analyse · 18 RCTs · 11,253 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Skin healthAntibiotikafreie Reduktion entzündlicher Akneläsionen (in einer Studie vergleichbar mit Clindamycin) · 8 weeks · Verbesserte Barrierefunktion (geringerer TEWL) und reduzierte Fahlheit/rote Flecken (kosmetisch) · 4-12 weeks · Moderate Reduktion feiner Linien aus einer industriegesponserten Split-Face-Studie (kosmetisch; der schwächste Teil der Evidenz) · 8-12 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Skin tone & pigmentationModerate Reduktion der Hyperpigmentierung und verbesserte Hautaufhellung/-klarheit (kosmetisch, kein gesundheitliches Ergebnis) · 4-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Therapeutic & clinical
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Kidney & renal health
Zu wenige bewertete Studien2 Studien
Vision & eye health
Zu wenige bewertete Studien1 Studie
Stetige Forschung
5 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199320092026
1Meta-Analysen=1,723 · large study2025
Einfach gesagt: However, the variability among the included studies highlights the necessity for well-structured, long-term RCTs to determine the ideal dosage, treatment duration, and target patient populations that would derive the greatest benefit from vitamin-based interventions.
Kuo WH, Chang KS, Chang MH, Hsiao Y, Tsai RY. · International journal of molecular sciences (2025)
Compared to placebo, vitamin supplementation demonstrated a significant reduction in pruritus severity (Standardized Mean Difference [SMD]: -0.578, 95% CI: -0.736 to -0.419, p = 0.000; I 2 = 53.630, p = 0.003).
Sensitivity analysis confirmed the robustness of the findings; however, potential publication bias was suggested by Egger's regression test ( p = 0.00979), indicating that the overall effect may be influenced by small-study effects or underreporting of negative results.
Subgroup analysis revealed that topical vitamin B12 and vitamin D3 showed the most pronounced antipruritic effects, particularly in patients with atopic dermatitis and chronic kidney disease-associated pruritus.
Einfach gesagt: Despite the small number of studies identified, the emerging evidence provided some insights into the primary prevention of certain skin diseases and may serve as a foundation for future studies.
Granvillano G, Mercogliano M, Vecchietti A, Minutolo G, Lugli C, Strano P, Chimienti M, Pellegrini M, Briganti GL, Spatari G, Leonforte F, Urbano T, Lorenzon A. · Preventive nutrition and food science (2026)
A total of six studies were included in this umbrella review, which covered a period between 2001 and 2023 and included a total of 9,229 participants, either in utero or aged 0－80 years old.
The preventive effect of green tea catechins on ultraviolet radiation-induced erythema was highlighted, as well as the role of Lactobacillus probiotics in infant atopic eczema.
Finally, niacinamide supplementation reduced the incidence of basal and squamous cell carcinoma (the major subtypes of non-melanoma skin cancer).
Nicola CA, Marinescu MC, Firan AM, Tartea G, Naidin MS, Ciuluvica RC, Dimulescu MD, Voicu NM, Mihailescu CM, Meca AD, Bogdan M, Turcu-Stiolica A. · Nutrients (2025)
In addition, B3 treatment resulted in a significant reduction in intraocular pressure in both eyes over 6 months (mean difference = 0.53, 95% CI: [0.21, 0.86] in the left eye and mean difference = 0.36, 95% CI: [0.04, 0.68] in the right eye), indicating potential clinical benefits.
Conclusions: The observed GQL-15 score reductions suggest that B3 may be of benefit in glaucoma management.
Further research with larger sample sizes and placebo-controlled designs is needed to confirm B3 potential impact on disease progression and quality of life.
Einfach gesagt: Evidence has shown ascorbic acid, azelaic acid, glycolic acid, kojic acid, salicylic acid, and niacinamide to be effective as adjuvant therapies with minimal side effects.
González-Molina V, Martí-Pineda A, González N. · J Clin Aesthet Dermatol (2022)
PRISMA systematic review of topical melasma agents: 348 studies screened, 80 met inclusion criteria
Niacinamide is classified as an effective adjuvant therapy with minimal side effects
Triple-combination therapy and hydroquinone remain the strongest-evidence, gold-standard treatments — niacinamide is positioned as adjuvant, not first-line; reviewers note small samples and a lack of large, long-term trials
18RCTn=18 · very small study2002
Einfach gesagt: In the clinical studies, niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use.
Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE. · Br J Dermatol (2002)
Paired clinical trial: 18 subjects with hyperpigmentation used 5% niacinamide vs vehicle moisturizer (plus a separate facial-tanning arm)
5% niacinamide significantly reduced hyperpigmentation and increased skin lightness vs vehicle by 4 weeks
Mechanistically, niacinamide gave 35-68% inhibition of melanosome transfer in coculture but had no effect on tyrosinase or melanocyte melanogenesis
Einfach gesagt: Analyses of the data revealed a variety of significant skin appearance improvement effects for topical niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing).
Bissett DL, Oblong JE, Berge CA. · Dermatol Surg (2005)
Double-blind, left-right randomized split-face design: 5% niacinamide vs vehicle applied twice daily for 12 weeks in 50 white women with facial photoaging
Significant improvements vs vehicle in fine lines/wrinkles, hyperpigmented spots, red blotchiness, and yellowing (sallowness)
Elasticity improved by cutometry; well tolerated. Foundational facial-aging cosmetic trial (Procter & Gamble)
Split-face RCT in 27 melasma patients: 4% niacinamide vs 4% hydroquinone (HQ) for 8 weeks, both with sunscreen
Both sides improved with no significant colorimetric difference, but good-to-excellent response was lower with niacinamide (44%) than HQ (55%)
Niacinamide had fewer side effects (18% vs 29% with HQ) and reduced mast-cell infiltrate and solar elastosis histologically — the key counter-evidence positioning it as a better-tolerated but slightly weaker alternative