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Ole7.0
Olive Leaf Extract – Forschung
Hilft wahrscheinlich
103 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Olive Leaf Extract scheint in 9 von 11 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1991–2026 mit einer typischen Studiengröße von 70 Teilnehmenden.
Basierend auf 103 Studien · 8 Meta-Analysen · 68 RCTs · 6,786 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
9geholfen1unklar1nicht geholfen· 92 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureModerate Blutdrucksenkung; die Wirkung auf die Blutfette ist uneinheitlich und inkonsistent · 4-8 weeks
Hilft wahrscheinlich80 Studien
InflammationModerate Blutdrucksenkung · 8 weeks
Hilft wahrscheinlich24 Studien
Glucose & metabolic
Hilft wahrscheinlich16 Studien
Cholesterol & lipidsModerate Blutdrucksenkung; die Wirkung auf die Blutfette ist uneinheitlich und inkonsistent · 4-8 weeks
Hilft wahrscheinlich9 Studien
Immune supportVerbesserte Immunfunktion und antimikrobielle Aktivität · 2-4 weeks
Überwiegend Mechanismus / Beobachtung8 Studien
Weight management
Überwiegend Mechanismus / Beobachtung7 Studien
Women's healthKann zur Linderung von Wechseljahrsbeschwerden wie Hitzewallungen und Stimmungsschwankungen beitragen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Cold sores & HSV
Zu wenige bewertete Studien2 Studien
Joint pain & arthritis
Zu wenige bewertete Studien2 Studien
Digestive health
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Liver health
Zu wenige bewertete Studien1 Studie
Therapeutic & clinical
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 42 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
6,786
typische Studie: 70 Personen
Stärkste Designs
76
8 gepoolt, 68 randomisiert
Zeigte Nutzen
82%
9/11 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–3 Monate
4
Untersuchte Populationen
General population4
Hypertensive patients2
Patients with herpes labialis1
Individuals assessed for cardiometabolic risk factors1
Aktives Forschungsgebiet
58 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
199120082026
1Herpes labialis healing time and symptom reductionSystematische ÜbersichtCited 2×n=1,250 · large study2025
Future well-designed, large-scale RCTs employing standardized methodologies are necessary to confirm these findings and to establish optimal treatment protocols for diverse patient populations (Inplasy protocol number: 202350038).
Anheyer M et al. · Journal of integrative and complementary medicine (2025)
Lemon balm preparations consistently reduced pain intensity and swelling, with some studies also reporting a significant decrease in lesion size compared with placebo or acyclovir.
Olive leaf extract demonstrated a statistically significant faster improvement in symptoms and a shorter healing time compared with acyclovir.
Discussion: The findings indicate that topical herbal therapies may provide effective and well-tolerated alternatives or adjuncts to conventional antiviral treatments for herpes labialis.
Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.
Frumuzachi O et al. · Critical reviews in food science and nutrition (2025)
Fourteen human intervention studies with 594 participants were included.
Subgroup analysis showed that, in certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, and cardiometabolic disease individuals, while intervention compound, type of intervention, and duration might have differential effects regarding considered outcomes.
Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.
Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.
Ussia S et al. · Nutrients (2025)
The beneficial effect was attributed to the polyphenols contained in EVOO.
Indeed, EVOO supplementation as part of the Mediterranean diet could improve patients' quality of life in secondary prevention by demonstrating a positive correlation with the cardioprotective role of polyphenols.
Discussion: A balanced diet with VOO represents a simple yet potent method to counteract metabolic dysfunctions associated with CVD.
We conclude that EVOO and its OOPCs can regulate gene expression by modifying epigenetic mechanisms that impact human pathophysiology.
Del Saz-Lara A et al. · Advances in nutrition (Bethesda, Md.) (2022)
We conclude that EVOO and its OOPCs can regulate gene expression by modifying epigenetic mechanisms that impact human pathophysiology.
A full elucidation of the epigenetic effects of EVOO and its OOPCs may contribute to developing different pharma-nutritional strategies that exploit them as epigenetic agents.
Further investigations are necessary to clarify the real chemopreventive potential of olive oil secoiridoid phenols on humans performing intervention studies on populations at high cancer risk.
Fabiani R · Food & function (2016)
All human intervention trials have investigated the effects of olive oil phenols on DNA damage.
Among the five selected studies, three have shown a significant preventive effect on oxidative DNA damage in terms of reduction of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine, in mitochondria DNA of mononuclear cells and in lymphocyte DNA.
The other two studies failed to see an effect on the urinary excretion of either etheno-DNA adducts or oxidation products of guanine.
Special attention is given to their mechanistic actions and therapeutic potential in the context of iron-related disorders.
Freitas SML et al. · Critical reviews in food science and nutrition (2026)
Emerging evidence suggests that these compounds influence the expression and activity of iron-regulatory proteins such as hepcidin, ferroportin (FPN), ferritin, transferrin, and divalent metal transporter 1 (DMT1).
Their biological effects are frequently attributed to antioxidant, metal-chelating, and anti-inflammatory properties.
This review provides a comprehensive overview of selected plant-derived bioactive compounds-curcumin, catechins, quercetin, resveratrol, sulforaphane, tannins, myricetin, apigenin, and oleuropein-and their roles in iron metabolism and homeostasis.
Further well-designed, long-term clinical trials are needed to establish causal relationships, optimize dosage, and explore biomarker-driven personalized nutrition approaches.
Fekete M, Jarecsny T, Lehoczki A, Major D, Fazekas-Pongor V, Csípő T, Lipécz Á, Szappanos Á, Pázmándi EM, Varga P, Varga JT. · Nutrients (2025)
Clinical studies, although limited, indicate beneficial effects of polyphenol-rich interventions on cognitive and metabolic biomarkers.
Conclusions: Current evidence supports the Mediterranean diet as a promising dietary strategy to slow the progression of neurodegenerative diseases.
Polyphenols, including resveratrol and oleuropein, may play a role in mediating these effects.