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Om39.0
Omega-3 – Forschung
Hilft vermutlich
987 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Omega-3 scheint in 13 von 17 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2015–2026 mit einer typischen Studiengröße von 293 Teilnehmenden.
Basierend auf 982 Studien · 275 Meta-Analysen · 583 RCTs · 543,722 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
13geholfen3unklar1nicht geholfen· 965 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureDHA ist ein entscheidender struktureller Bestandteil des Gehirns und unterstützt das Gedächtnis · 8-12 Wochen
Hilft wahrscheinlich821 Studien
Therapeutic & clinical
Hilft wahrscheinlich147 Studien
Women's healthNiedrigere Entzündungsmarker · 2-4 Wochen · Kann die reproduktive Gesundheit und Fertilitätsmarker unterstützen · 4-12 Wochen · Entzündungshemmende Unterstützung während des menopausalen Übergangs · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung106 Studien
Cognitive functionDHA-reich; reduziert Neuroinflammation und unterstützt das kognitive Altern · 8-16 Wochen
Überwiegend Mechanismus / Beobachtung64 Studien
Glucose & metabolicHöherer Omega-3-Status ist mit besserer Schlafqualität assoziiert · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung44 Studien
Cholesterol & lipidsDHA ist ein entscheidender struktureller Bestandteil des Gehirns und unterstützt das Gedächtnis · 8-12 Wochen
Joint pain & arthritisKann helfen, Menstruationsbeschwerden und PMS-Symptome zu verringern · 1-3 Zyklen
Überwiegend Mechanismus / Beobachtung10 Studien
Bone health
Überwiegend Mechanismus / Beobachtung10 Studien
Anxiety & stressVerbessert das Lipidprofil und verbessert moderat die Insulinsensitivität · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung9 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung9 Studien
Endurance & exercise performance
Überwiegend Mechanismus / Beobachtung8 Studien
Longevity & aging
Überwiegend Mechanismus / Beobachtung8 Studien
Skin health
Überwiegend Mechanismus / Beobachtung7 Studien
Focus & attentionLiefert essenzielle Nährstoffe für eine gesunde Schwangerschaft · Fortlaufend
Überwiegend Mechanismus / Beobachtung4 Studien
Fertility & reproductiveVerbesserte Triglyzeride und kardiovaskuläre Marker innerhalb von 4-8 Wochen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Sleep & insomniaHigher omega-3 status associated with better sleep quality · 8-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
In Zahlen
Aus 51 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
82%
über Studien hinweg
Untersuchte Personen
544k
typische Studie: 293 Personen
Stärkste Designs
858
275 gepoolt, 583 randomisiert
Zeigte Nutzen
76%
13/17 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
5
Untersuchte Populationen
Adults3
Cardiovascular patients3
General population3
Pregnant women2
Aktives Forschungsgebiet
738 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
201520202026
1muscle strength, endurance, and recoveryMeta-Analysen=1,211 · large study2026
Einfach gesagt: These findings reveal an outcome-specific efficacy pattern supporting targeted supplementation strategies aligned with primary training objectives in athletic populations.
Wang Z et al. · Nutrients (2026)
The analysis incorporated 35 trials enrolling 1211 participants.
Network consistency assessment revealed no significant disagreement between direct and indirect evidence across all outcomes.
These findings reveal an outcome-specific efficacy pattern supporting targeted supplementation strategies aligned with primary training objectives in athletic populations.
2Depressive disorder symptomsMeta-Analysen=17,437 · very large study2025
Einfach gesagt: This extensive systematic review and NMA of nutraceuticals for treating depressive disorders indicated a number of nutraceuticals that could offer benefits, either as adjuncts or monotherapies.
Cheng YC et al. · Psychological medicine (2025)
Adjunctive nutraceuticals consistently showed better efficacy than antidepressants (ADT) alone in outcomes including SMD, remission, and response.
This extensive systematic review and NMA of nutraceuticals for treating depressive disorders indicated a number of nutraceuticals that could offer benefits, either as adjuncts or monotherapies.
3Incident atrial fibrillationMeta-Analysen=54,799 · very large study2023
Einfach gesagt: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF.
Qian F et al. · Journal of the American College of Cardiology (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05).
HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively.
In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF.
4Anxiety and depressionMeta-Analysen=1,426 · large study2023
Einfach gesagt: Only one study reported significant reduction in anxiety severity with 2.1 g/day EPA (85.6% of total EPA + DHA), therefore meta-analysis was not possible.
Kelaiditis CF et al. · Prostaglandins, leukotrienes, and essential fatty acids (2023)
Only one study reported significant reduction in anxiety severity with 2.1 g/day EPA (85.6% of total EPA + DHA), therefore meta-analysis was not possible.
These results support the therapeutic potential of EPA in depression at proportions ≥ 60% of total EPA + DHA and doses ≥ 1 g/day and < 2 g/day.
5Depressive symptomsSystematische Übersichtn=4,500 · very large study2021
Einfach gesagt: Our primary analyses may suggest a small-to-modest, non-clinically beneficial effect of n-3PUFAs on depressive symptomology compared to placebo; however the estimate is imprecise, and we judged the certainty of the evidence on which this result is based to be low to very low.
Appleton KM et al. · Cochrane Database of Systematic Reviews (2021)
At present, we do not have sufficient high-certainty evidence to determine the effects of n-3PUFAs as a treatment for MDD.
Primary analyses may suggest a small-to-modest, non-clinically beneficial effect of n-3PUFAs on depressive symptomology compared to placebo.
More complete evidence is required for both the potential positive and negative effects of n-3PUFAs for MDD.
Einfach gesagt: The find-ings highlight the heterogeneity in responses to omega-3 fatty acid supplementation and emphasize the need for cautious interpretation.
Fei L et al. · Asia Pacific journal of clinical nutrition (2024)
The meta-analysis revealed a neutral overall effect size of omega-3 fatty acid supplementation on proteinuria levels, assessed under both common and random effect models.
Despite the lack of statistically significant evidence supporting the efficacy of omega-3 fatty acids in reducing proteinuria, the variability in interventions and patient populations suggests potential individual responses.
The find-ings highlight the heterogeneity in responses to omega-3 fatty acid supplementation and emphasize the need for cautious interpretation.
7Cardiovascular events and coronary revascularizationMeta-Analysen=144 · medium study2024
Einfach gesagt: Omega-3 fatty acid supplementation reduced the risk of cardiovascular events and coronary revascularization, regardless of background statin use.
Dinu M et al. · European journal of preventive cardiology (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Lower risk was still observed in trials where most participants (≥60%) were on statin therapy.
Compared with DHA + EPA, EPA alone showed a further significant risk reduction of revascularizations (0.76, 95% CI 0.65-0.88; P = 0.0002; P-interaction = 0.005) and all outcomes except HF.
Omega-3 fatty acid supplementation reduced the risk of cardiovascular events and coronary revascularization, regardless of background statin use.
9Patient important outcomes after myocardial infarctionMeta-Analysen=24,414 · very large study2019
Einfach gesagt: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.
Popoff F et al. · BMC cardiovascular disorders (2019)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty).
There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty).
For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.
10Depressed moodMeta-AnalyseCited 48×n=4,605 · very large study2018
Einfach gesagt: In the well-being mental health group, the Hedges g was 0.12 (95% confidence interval, -0.05 to 0.29), which indicated no significant effect of n-3 PUFA supplementation on depressed mood compared w...
Bae JH et al. · Nutrition research (New York, N.Y.) (2018)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
In the well-being mental health group, the Hedges g was 0.12 (95% confidence interval, -0.05 to 0.29), which indicated no significant effect of n-3 PUFA supplementation on depressed mood compared with placebo.
In the depressive group, the pooled Hedges g was -0.94 (95% CI, -1.37 to -0.50]) for the random-effects model, which indicated a large effect of n-3 PUFA supplementation on those with depressed mood compared with placebo.
Although this review shows that omega-3 fatty acids are effective in the treatment of elderly depressed patients, the benefits of omega-3 fatty acid supplementation were significant only in the elderly patients with mild to moderate depression.