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Pgn6.0
Panax Ginseng – Forschung
Hilft wahrscheinlich
68 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Panax Ginseng scheint in 11 von 13 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 149 Teilnehmenden.
Basierend auf 68 Studien · 7 Meta-Analysen · 12 RCTs · 11,892 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
11geholfen1unklar1nicht geholfen· 55 weitere ohne bewertete Effektdaten
Nach Outcome
Energy & fatigueReduzierte Müdigkeit und verbesserte Vitalität · 2-4 weeks
Hilft wahrscheinlich51 Studien
Therapeutic & clinical
Hilft wahrscheinlich18 Studien
Cognitive functionGinsenoside verbessern die kognitive Funktion und das Arbeitsgedächtnis · 4-8 weeks
Überwiegend Mechanismus / Beobachtung10 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Glucose & metabolic
Hilft wahrscheinlich5 Studien
Depression & moodVerbessert das subjektive Wohlbefinden und die Lebensqualitäts-Scores · 4-8 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Immune supportImmunmodulatorische Ginsenoside steigern die Aktivität der NK-Zellen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung3 Studien
Anxiety & stressKann die Stressresilienz verbessern · 4 weeks · Verbesserte Stressanpassung und mentale Ausdauer · 2-4 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Endurance & exercise performanceAdaptogene Unterstützung verbessert die körperliche Leistungsfähigkeit und VO2max · 4-8 weeks · Moderate Verbesserungen der Ausdauer und der Ermüdungsresistenz · 4-8 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung3 Studien
Men's vitalityUnterstützung der Erektionsfunktion und der Libido · 4-8 weeks
Zu wenige bewertete Studien2 Studien
Women's health
Zu wenige bewertete Studien1 Studie
Weight management
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 46 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
12k
typische Studie: 149 Personen
Stärkste Designs
19
7 gepoolt, 12 randomisiert
Zeigte Nutzen
85%
11/13 Studien
Wie lange Studien liefen
1–4 Wochen
2
3+ Monate
1
Untersuchte Populationen
COPD patients2
Men with erectile dysfunction2
Healthy adults2
General population2
Aktives Forschungsgebiet
47 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200620162026
1BODE IndexSystematische ÜbersichtCited 27×n=1,834 · large study2014
These issues should be addressed in future trials.
Chen X et al. · PloS one (2014)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The main meta-analysis results showed relative benefits for BODE Index in nine studies (mean difference [MD] -0.71, 95% confidence interval [CI] -0.94, -0.47) and 6MWT/D in 17 studies (MD 54.61 meters, 95%CI 33.30, 75.92) in favour of the CHM plus RP groups.
Detailed sub-group and sensitivity analyses were conducted.
Clinically meaningful benefits for BODE Index and 6MWT were found in multiple studies.
The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection.
Todorova V et al. · Nutrients (2021)
Extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis are considered to be naturally occurring adaptogens and, in particular, plant adaptogens.
About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body's resistance to stress and to improve physical endurance.
Although now many people take plant adaptogens, the clinical trials on human are limited.
3Chemotherapy-induced nausea and vomiting (CINV)Meta-AnalyseCited 40×n=1,843 · large study2016
The oxaliplatin plus TM groups showed significantly reduced CINV (risk ratio 0.65 [0.59, 0.71], I(2) = 28%) compared with oxaliplatin controls, with or without the addition of conventional anti-eme...
Chen MH et al. · Phytotherapy research : PTR (2016)
Groß Nutzen
← SchlechterKein EffektBesser →
The oxaliplatin plus TM groups showed significantly reduced CINV (risk ratio 0.65 [0.59, 0.71], I(2) = 28%) compared with oxaliplatin controls, with or without the addition of conventional anti-emetics.
These plants warrant further clinical research as potential additions to chemotherapy regimens in patients whose CINV is not sufficiently well controlled by conventional therapies.
4Sexual arousalMeta-AnalyseCited 2×n=536 · large study2021
Preliminary evidence suggests that Tribulus terrestris and Panax ginseng may be effective as alternative treatments for FSD in a clinical setting.
Sha'ari N et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2021)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Panax ginseng was found to be effective in treating sexual arousal (SMD = 0.54, 95% CI = 0.11 - 0.97, p = 0.014) and sexual desire (SMD = 0.59, 95% CI = 0.27 - 0.90, p < 0.001) compared to placebo.
Preliminary evidence suggests that Tribulus terrestris and Panax ginseng may be effective as alternative treatments for FSD in a clinical setting.
5Systematische ÜbersichtCited 17×n=129 · medium study2021
Combinations between chronic cannabis use and selective serotonin reuptake inhibitors or non-steroidal antiinflammatory drugs should be carefully monitored, whereas no significant evidence for drug-interactions between conventional MS-drugs and ginger, cranberry, vitamin D, fatty acids, turmeric, probiotics or glucosamine was found.
Petersen MJ et al. · Phytotherapy research : PTR (2021)
A total of 129 published papers found via PubMed and Web of Science were reviewed according to defined inclusion- and exclusion criteria.
Findings suggested that daily recommended doses of Panax ginseng and Ginkgo biloba should not be exceeded, and herbal preparations differing from standardized products should be avoided, especially when combined with anticoagulants or substrates of certain cytochrome P450 isoforms.
Further studies are required regarding ginseng's ability to increase aspirin bioavailability.
6Diabetes and chronic complicationsSystematische ÜbersichtCited 22×2025
In summary, this review elucidates the happening mechanisms of pyroptosis in diabetes and associated chronic complications, and summarizes published studies about ginseng and its active ingredients in improving diabetes by regulating pyroptosis-related pathways.
Li K et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)
In summary, this review elucidates the happening mechanisms of pyroptosis in diabetes and associated chronic complications, and summarizes published studies about ginseng and its active ingredients in improving diabetes by regulating pyroptosis-related pathways.
However, almost all researches are limited to animal and cell experiments, and more clinical trials are required to prove the therapeutic effect of ginseng on diabetes by targeting pyroptosis.
7Pharmacological properties of ginsenoside RfSystematische Übersicht2025
This mini-review also delves into the pharmacokinetics of Rf and the potential for future studies, intending to offer a comprehensive insight into Rf and its possible application in medical and pharmacological domains.
Li P et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)
9Antiaging mechanisms of dietary saponinsSystematische ÜbersichtCited 2×2025
Future antiaging research on dietary saponins should prioritize high-purity monomers, optimize their bioactive structure, and yield via synthetic biology and nanoencapsulation, followed by clinical validation of efficacy.
Guo C et al. · Journal of agricultural and food chemistry (2025)
Moreover, some antiaging products based on dietary saponins have been developed and utilized as functional foods or nutritional supplements to achieve antiaging in human wellness.
This review systematically reviews antiaging mechanisms of dietary saponins, including their structure-activity relationship, from fundamental research to the development of associated products.
Future antiaging research on dietary saponins should prioritize high-purity monomers, optimize their bioactive structure, and yield via synthetic biology and nanoencapsulation, followed by clinical validation of efficacy.
11Efficacy of dietary supplements for erectile dysfunctionMeta-AnalyseCited 12×2023
DSs marketed in Italy are usually blends of many substances that are frequently employed at a negligible dose or without any evidence.
Petre GC et al. · Nutrients (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy.
A systematic review of the literature was performed to evaluate the effect of DS and to detect the active ingredients able to improve erectile function-called effective ingredients (EIs)-and their minimal effective daily dose (mED).
A metanalysis identified some nutraceuticals, such as Panax ginseng, Tribulus terrestris and L-arginine, that are able to improve male sexual function.
Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions.
Arabi SM et al. · Current pharmaceutical design (2024)
The Weighted Mean Differences (WMD) and 95% Confidence Intervals (CI) for TG, TC, LDL-C, and HDL-C did not show significant changes with ginseng supplementation.
Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions.
Further, well-designed RCTs focusing on specific diseases are needed to clarify the potential beneficial effects of ginseng and its derivatives on lipid profile.
The safety and further clinical trials of CK should be explored for future drug development.
Tam DNH et al. · Fundamental & clinical pharmacology (2023)
The purity of CK in our included studies was at least 95%.
The in vivo studies reported a significant decrease in tumor volume in mice treated with CK.
The in vitro studies reported that CK had a potential anticancer activity on several cell lines including human lung cancer cell lines (A549, PC-9), nasopharyngeal carcinoma cell line (Hk-1), liver cancer cell line (BEL 7402), and pediatric acute myeloid leukemia cell lines (Kasumi-1, MV4-11).
15Systematische ÜbersichtCited 31×n=200 · medium study2020
This review could assist the basic researchers and clinical doctors to understand current status and problem of ginseng clinical research, and perhaps could benefit for the reasonable and accurate ...
Fan S et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2020)
This review could assist the basic researchers and clinical doctors to understand current status and problem of ginseng clinical research, and perhaps could benefit for the reasonable and accurate design of future clinical studies.
This systematic review suggests that the ingestion of PGPs or ginsenosides, especially Rg1, is effective in improving exercise endurance in healthy adults.
Ikeuchi S et al. · Nutrients (2022)
Groß Nutzen
← SchlechterKein EffektBesser →
We found that ingestion of PGPs or ginsenosides significantly improved exercise endurance (SMD [95% CI]: 0.58 [0.22-0.95], I2 = 0%).
It was suggested that ginsenoside Rg1 (Rg1) and PGPs extract containing Rg1 were significantly effective in improving exercise endurance (SMD [95% CI]: 0.70 [0.14-1.27], I2 = 30%) by additional analysis.
This systematic review suggests that the ingestion of PGPs or ginsenosides, especially Rg1, is effective in improving exercise endurance in healthy adults.
Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways.
Pferschy-Wenzig EM et al. · Nutrients (2022)
Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways.
However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites.
Data for Panax ginseng, Schisandra chinensis, and Salvia rosmarinus indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits.
The use of this plant in cancer resulted in improved quality of life and mood.
de Oliveira Zanuso B et al. · Experimental gerontology (2022)
The use of this plant in cancer resulted in improved quality of life and mood.
It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Panax ginseng has been shown to exert potent therapeutic benefits that can act as a complementary treatment in managing patients with chronic diseases related to aging.
19Systematische ÜbersichtCited 58×n=57 · small study2011
However, ginseng generally has a good safety profile and the incidence of adverse effects seems to be low.
Lee NH et al. · Journal of acupuncture and meridian studies (2011)
However, ginseng generally has a good safety profile and the incidence of adverse effects seems to be low.
In conclusion, our review compiles the evidence on the use of ginseng, finding a strong positive potential for glucose metabolism, psychomotor function, and pulmonary disease, but not for physical performance enhancement.