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Pda2.0

Pau D'Arco – Forschung

Überwiegend Mechanismus / Beobachtung

5 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Pau D'Arco sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus mittelwertigen Studien, veröffentlicht 1976–2021.

Basierend auf 5 Studien

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1 Studie in den letzten 5 Jahren

197619982021

1Übersicht1976

Einfach gesagt: A review of plant antitumor agents discussed lapachol among them and noted its toxicity during early drug evaluation.

Sieber SM, Mead JA, Adamson RH · Cancer Treat Rep (1976)

A review of plant-derived antitumor agents that included lapachol (pau d'arco's active naphthoquinone)
Noted lapachol's general toxicity during early antitumor drug evaluation
Lapachol's anticoagulant/GI toxicity (documented in later clinical trials) underpins the bleeding-risk caution

2Tierstudie2017

Einfach gesagt: In a rat model and cell lines, Tabebuia bark extract reduced inflammatory mediators by targeting NF-kB and AP-1 — but this is preclinical, not human, evidence.

Park JG et al. · Mediators Inflamm (2017)

Bark ethanol extract reduced osteoarthritis symptoms and serum inflammatory cytokines in rats
Suppressed pro-inflammatory mediators in macrophage-like cells via NF-kB and AP-1 pathways
Preclinical (rat + in-vitro) only — no human data

Quelle ansehen

3Tierstudie2013

Einfach gesagt: Bark extract accelerated gastric ulcer healing in rats — an animal finding consistent with traditional use, not a human trial.

Pereira IT et al. · Phytother Res (2013)

Ethanolic bark extract (100-300 mg/kg) reduced acetic-acid-induced gastric ulcers by 36-44% in rats
Increased mucus content and gastric cell proliferation
Animal study only — no human efficacy data

Quelle ansehen

4In vitro2014

Einfach gesagt: Beta-lapachone, a naphthoquinone from Tabebuia bark, was cytotoxic to lung cancer cell lines in vitro — a test-tube finding, not evidence of benefit in people.

Kung HN et al. · PLoS One (2014)

Beta-lapachone induced apoptosis in lung cancer cell lines via NQO1-dependent mechanisms
Cytotoxicity correlated with NQO1 expression and activity
In-vitro cell study only — does not support use as a supplement

Quelle ansehen

5Übersicht2021

Einfach gesagt: A review found naphthoquinones including lapachol show antibacterial, antifungal, and antiprotozoal activity in vitro, but none are established anti-infective therapies in humans.

Ortiz-Perez E et al. · Curr Top Med Chem (2021)

Lapachol and related naphthoquinones show antiparasitic activity in vitro comparable to reference drugs
Activity is at the molecular/chemistry level, not from clinical use
Review of preclinical data — no human efficacy evidence for pau d'arco

Quelle ansehen

In der Forschungsbibliothek ansehen

Pau D'Arco – Forschung

Überwiegend Mechanismus / Beobachtung

Pharmacology of antitumor agents from higher plants.

Tabetri (Tabebuia avellanedae Ethanol Extract) Ameliorates Osteoarthritis Symptoms Induced by Monoiodoacetate through Its Anti-Inflammatory and Chondroprotective Activities.

Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process.

Sulindac compounds facilitate the cytotoxicity of beta-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.

Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents.