Polyhydroxy Acids (PHA) – Forschung

A double-blind, randomized clinical trial of 20% alpha/poly hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis.

Akamine KL, Gustafson CJ, Yentzer BA, Edison BL, Green BA, Davis SA · J Drugs Dermatol (2013)

Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive.

Gentili G, Perugini P, Bugliaro S, D'Antonio C · J Cosmet Dermatol (2023)

Alpha hydroxyacids modulate stratum corneum barrier function.

Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B · Br J Dermatol (1997)

Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid.

Einfach gesagt: LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment.

Tasic-Kostov M, Savic S, Lukic M, Tamburic S, Pavlovic M, Vuleta G. · J Cosmet Dermatol (2010)

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen.

Einfach gesagt: Both regimens showed significant antiaging benefits to skin as measured by silicone replicas, clinical grading, and pinch recoil for skin resiliency.

Edison BL, Green BA, Wildnauer RH, Sigler ML. · Cutis (2004)

Applications of hydroxy acids: classification, mechanisms, and photoactivity.

Einfach gesagt: In spite of the large number of reports on the cosmetic and clinical effects of HAs, their biological mechanism(s) of action still require more clarification.

Kornhauser A, Coelho SG, Hearing VJ. · Clin Cosmet Investig Dermatol (2010)

Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.

Einfach gesagt: We lowered the pH of mouse SC using two polyhydroxyl acids (PHA), lactobionic acid (LBA), or gluconolactone (GL).

Hachem JP, Roelandt T, Schürer N, Pu X, Fluhr J, Giddelo C, Man MQ, Crumrine D, Roseeuw D, Feingold KR, Mauro T, Elias PM. · J Invest Dermatol (2010)

The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging.

Einfach gesagt: Gluconolactone provided up to 50% protection against UV radiation, as measured in our in vitro system, and did not significantly increase sunburn cells in human skin.

Bernstein EF, Brown DB, Schwartz MD, Kaidbey K, Ksenzenko SM. · Dermatol Surg (2004)

The use of polyhydroxy acids (PHAs) in photoaged skin.

Einfach gesagt: PHAs have been found to be compatible with clinically sensitive skin, including rosacea and atopic dermatitis, and can be used after cosmetic procedures.

Grimes PE, Green BA, Wildnauer RH, Edison BL. · Cutis (2004)